Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
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 PubChem ID
CID: 7048703
SID: 14964754
Canonical SMILES
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
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Compound Formula C15H12I3NO4
Compound Structure
Protein Name
 Protein Info 
Thyroid hormone receptor beta
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group A
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Nuclear hormone receptor subfamily 1 group A member 2
Uniprot ID
P10828
Gene Name
THRB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.26 nM
   TI
   LI
   LO
   TS
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 2.4 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 2 nM
2 IC50 = 0.257 nM
3 IC50 = 0.26 nM
4 IC50 = 2.9 nM
5 Kd = 0.081 nM
6 Kd = 0.087 nM
7 Kd = 0.1 nM
8 Kd = 0.14 nM
9 Ki = 0.08 nM
10 Ki = 0.68 nM
11 Ki = 2.29 nM