Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
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 PubChem ID
CID: 216239
SID: 14834034
Canonical SMILES
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
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Compound Formula C21H16ClF3N4O3
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 6599 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CL000252 WM266-4
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 6100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 3 nM
2 IC50 = 12 nM
3 IC50 = 12.7 nM
4 IC50 = 15 nM
5 IC50 = 22 nM
6 IC50 = 22.6 nM
7 IC50 = 24 nM
8 IC50 = 25 nM
9 IC50 = 26.4 nM
10 IC50 = 30 nM
11 IC50 = 38 nM
12 IC50 = 38.1 nM
13 IC50 = 43.04 nM
14 IC50 = 46 nM
15 IC50 = 52.3 nM
16 IC50 = 65 nM
17 IC50 = 76.2 nM
18 IC50 < 100 nM
19 IC50 = 114 nM
20 IC50 = 120 nM
21 IC50 = 136 nM
22 IC50 = 200 nM
23 IC50 = 310 nM
24 IC50 = 7300 nM
25 Kd = 260 nM
26 Kd = 540 nM
27 Ki = 22 nM
28 Ki = 38 nM