Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-Methyl-6-(phenylethynyl)pyridine
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 PubChem ID
CID: 3025961
SID: 56310595
Canonical SMILES
Cc1cccc(n1)C#Cc1ccccc1
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Compound Formula C14H11N
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 31 nM
   TI
   LI
   LO
   TS
3
IC50 = 39 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 13 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 32 nM
   TI
   LI
   LO
   TS
3
Kd = 8.6 nM
   TI
   LI
   LO
   TS
4
Ki = 3.4 nM
   TI
   LI
   LO
   TS
CL000041 LTK-
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CL000308 T-REx-CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 11.2 nM
   TI
   LI
   LO
   TS
2
Ki = 10.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4 nM
2 Ki = 36.31 nM