Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid
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 PubChem ID
CID: 119192
SID: 12014763
Canonical SMILES
COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O
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Compound Formula C32H31ClN4O5
Compound Structure
Protein Name
 Protein Info 
Neurotensin receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Neurotensin receptor
Uniprot ID
P30989
Gene Name
NTSR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
Kd = 8.4 nM
   TI
   LI
   LO
   TS
2
Kd = 8.9 nM
   TI
   LI
   LO
   TS
3
Kd = 9.2 nM
   TI
   LI
   LO
   TS
4
Kd = 19 nM
   TI
   LI
   LO
   TS
5
Kd = 23 nM
   TI
   LI
   LO
   TS
6
Kd = 27 nM
   TI
   LI
   LO
   TS
7
Kd = 33 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 31000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.99 nM