Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
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 PubChem ID
CID: 3081361
SID: 14761077
Canonical SMILES
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
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Compound Formula C22H24BrFN4O2
Compound Structure
Protein Name
 Protein Info 
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2673 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 < 15 nM
   TI
   LI
   LO
   TS
2
IC50 = 1660 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 175 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.04 nM
2 IC50 = 4 nM
3 IC50 = 9 nM
4 IC50 = 17 nM
5 IC50 = 22 nM
6 IC50 = 27.3 nM
7 IC50 = 31.3 nM
8 IC50 = 41.8 nM
9 IC50 = 45 nM
10 IC50 = 54 nM
11 IC50 = 62 nM
12 IC50 = 69 nM
13 IC50 = 70 nM
14 IC50 = 100 nM
15 IC50 = 110 nM
16 IC50 = 4834 nM
17 IC50 = 5980.5 nM
18 Kd = 470 nM
19 Kd = 820 nM