Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one

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PubChem ID

CID: 6072

SID: 87550962

Canonical SMILES	OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O Show/Hide
Compound Formula	C21H24O10

Compound Structure

Protein Name

Protein Info

Sodium/glucose cotransporter 2

Protein Classification

Transporter

Electrochemical transporter

SLC superfamily of solute carriers

SLC05 family of sodium-dependent glucose transporters

Uniprot ID

P31639

Gene Name

SLC5A2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	6
1	EC50 = 35 nM	TI LI LO TS
2	EC50 = 35.6 nM	TI LI LO TS
3	EC50 = 79 nM	TI LI LO TS
4	EC50 = 108 nM	TI LI LO TS
5	IC50 = 16.4 nM	TI LI LO TS
6	IC50 = 752 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 77 nM	TI LI LO TS
2	EC50 = 123 nM	TI LI LO TS
3	IC50 = 16 nM	TI LI LO TS
4	IC50 = 27.8 nM	TI LI LO TS
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 100000 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 38 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 58.6 nM	TI LI LO TS
2	IC50 = 67.3 nM	TI LI LO TS

Biochemical Assays