Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

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PubChem ID

CID: 9821250

SID: 14780138

Canonical SMILES	CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C Show/Hide
Compound Formula	C22H32N6

Compound Structure

Protein Name

Protein Info

Corticotropin-releasing factor receptor 1

Protein Classification

Membrane receptor

Family B G protein-coupled receptor

Peptide receptor (family B GPCR)

Corticotropin releasing factor receptor

Uniprot ID

P34998

Gene Name

CRHR1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	8
1	IC50 = 8.5 nM	TI LI LO TS
2	IC50 = 17 nM	TI LI LO TS
3	IC50 = 28.18 nM	TI LI LO TS
4	IC50 = 50 nM	TI LI LO TS
5	IC50 = 67 nM	TI LI LO TS
6	Kd = 0.303 nM	TI LI LO TS
7	Ki = 3.5 nM	TI LI LO TS
8	Ki = 12 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	Ki = 2.6 nM	TI LI LO TS
CL000016	IMR-32 Cell Line Info	Homo sapiens (Human)	4
1	IC50 = 4 nM	TI LI LO TS
2	Ki = 3 nM	TI LI LO TS
3	Ki = 5 nM	TI LI LO TS
4	Ki = 8.3 nM	TI LI LO TS
CL000041	LTK- Cell Line Info	Mus musculus (Mouse)	1
1	Ki = 7.8 nM	TI LI LO TS

Biochemical Assays

1	Ki = 3 nM