Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methylamino}-ethoxy)-phenyl]-methanesulfonamide

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PubChem ID

CID: 71329

SID: 12014163

Canonical SMILES	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 Show/Hide
Compound Formula	C19H27N3O5S2

Compound Structure

Protein Name

Protein Info

Potassium voltage-gated channel subfamily H member 2

Protein Classification

Ion channel

Voltage-gated ion channel

Potassium channels

Voltage-gated potassium channel

Uniprot ID

Q12809

Gene Name

KCNH2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	IC50 = 10 nM	TI LI LO TS
2	IC50 = 630.96 nM	TI LI LO TS
3	IC50 = 1460 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 125.89 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	IC50 = 4.1 nM	TI LI LO TS
2	IC50 = 9.2 nM	TI LI LO TS
3	IC50 = 13 nM	TI LI LO TS
4	IC50 = 15 nM	TI LI LO TS
5	IC50 = 48.98 nM	TI LI LO TS
6	Ki = 6.4 nM	TI LI LO TS
7	Ki = 7.7 nM	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 12.3 nM	TI LI LO TS

Biochemical Assays