General Information of the Protein
Protein ID
PT07544
Protein Name
Transcriptional activator Myb
Secondarily
Protein Name
Proto-oncogene c-Myb
Gene Name
MYB
Sequence
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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Uniprot ID
Primary ID:
P10242

Secondarily ID:
E9PI07
E9PLZ5
E9PNA4
E9PNL6
E9PRS2
P78391
P78392
P78525
P78526
Q14023
Q14024
Q708E4
Q708E7
Q9UE83
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Ensembl ID
ENSG00000118513
HGNC ID
HGNC:7545
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0577231
 Compound Info 
2-amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile
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C20H13N3O3
  1
1
IC50 = 8.7 nM
 Bioactivity Info 
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CP0568567
 Compound Info 
2-amino-4-(3,4,5-trimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C23H20N2O4
  1
1
IC50 = 9.1 nM
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CP0577088
 Compound Info 
2-amino-4-(3,5-dimethoxy-4-prop-2-ynoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C25H20N2O4
  1
1
IC50 = 11 nM
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CP0567677
 Compound Info 
2-amino-4-(4-ethoxy-3,5-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C24H22N2O4
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0568568
 Compound Info 
2-amino-4-(3,5-dimethoxy-4-prop-2-enoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C25H22N2O4
  1
1
IC50 = 14 nM
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CP0579069
 Compound Info 
2-amino-4-(4-chloro-3-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile
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C20H12ClFN2O
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0579070
 Compound Info 
2-amino-4-(4-butoxy-3,5-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C26H26N2O4
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0579834
 Compound Info 
2-amino-4-(3,5-dimethoxy-4-propoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C25H24N2O4
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0579330
 Compound Info 
2-amino-4-(3-bromo-4-ethoxy-5-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C23H19BrN2O3
  1
1
IC50 = 36.8 nM
 Bioactivity Info 
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CP0577282
 Compound Info 
2-amino-4-(3,4-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C22H18N2O3
  1
1
IC50 = 40 nM
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CP0569874
 Compound Info 
2-amino-4-(4-ethoxy-3-iodo-5-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C23H19IN2O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0577629
 Compound Info 
2-amino-4-(3,5-dimethoxy-4-propan-2-yloxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C25H24N2O4
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0567678
 Compound Info 
2-amino-4-(3,4,5-trifluorophenyl)-4H-benzo[h]chromene-3-carbonitrile
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C20H11F3N2O
  1
1
IC50 = 70 nM
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CP0567679
 Compound Info 
2-amino-4-(4-methoxy-3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H15N3O4
  1
1
IC50 = 110 nM
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CP0546799
 Compound Info 
2-amino-4-[3-(pentafluoro-lambda6-sulfanyl)phenyl]-4H-benzo[h]chromene-3-carbonitrile
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C20H13F5N2OS
  1
1
IC50 = 130 nM
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CP0571030
 Compound Info 
2-amino-4-(2-bromo-3,4,5-trimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C23H19BrN2O4
  1
1
IC50 = 130 nM
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CP0579950
 Compound Info 
2-amino-4-(4-methylsulfanylphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H16N2OS
  1
1
IC50 = 210 nM
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CP0567869
 Compound Info 
2-amino-4-(3-fluoro-4-methylsulfanylphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H15FN2OS
  1
1
IC50 = 240 nM
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CP0567675
 Compound Info 
2-amino-4-(4-cyanophenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H13N3O
  1
1
IC50 = 390 nM
 Bioactivity Info 
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CP0571031
 Compound Info 
2-amino-4-(3,5-dimethoxy-4-pentoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C27H28N2O4
  1
1
IC50 = 400 nM
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CP0579822
 Compound Info 
2-amino-4-(4-methoxy-3-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C22H18N2O2
  1
1
IC50 = 400 nM
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CP0567680
 Compound Info 
2-amino-4-(3-bromo-4-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H15BrN2O2
  1
1
IC50 = 420 nM
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CP0546800
 Compound Info 
2-amino-4-(4-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H16N2O
  1
1
IC50 = 430 nM
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CP0578691
 Compound Info 
2-amino-4-(3-methoxy-4-phenylmethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C28H22N2O3
  1
1
IC50 = 1000 nM
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CP0567674
 Compound Info 
2-amino-4-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-4H-benzo[h]chromene-3-carbonitrile
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C20H13F5N2OS
  1
1
IC50 = 3200 nM
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CP0577630
 Compound Info 
2-amino-4-(4-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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C21H16N2O2
  1
1
IC50 = 3700 nM
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Clinical Information about the Protein
Target 1 ( Myb messenger RNA (MYB mRNA) )
Target Type Clinical trial Target