General Information of the Compound
Compound ID
CP0567677
Compound Name
2-amino-4-(4-ethoxy-3,5-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
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Structure
Formula
C24H22N2O4
Molecular Weight
402.45
Canonical SMILES
CCOc1c(OC)cc(cc1OC)C1C(C#N)=C(N)Oc2c1ccc1ccccc21
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InChI
InChI=1S/C24H22N2O4/c1-4-29-23-19(27-2)11-15(12-20(23)28-3)21-17-10-9-14-7-5-6-8-16(14)22(17)30-24(26)18(21)13-25/h5-12,21H,4,26H2,1-3H3
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InChIKey
MFWGVEDLBIPFGB-UHFFFAOYSA-N
Physicochemical Property
logP
4.47388
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
86.73
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168282153
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07544, Transcriptional activator Myb
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 14 nM
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