General Information of the Protein
Protein ID
PT07030
Protein Name
Dedicator of cytokinesis protein 5
Gene Name
DOCK5
Sequence
MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTIALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIALLQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVVSTSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSENRISKFKRKDWSLSKSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQSTPLSPPPLTPKATRTLSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPPPPPPKARKSGIPTSEPGSQ
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
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Uniprot ID
Primary ID:
Q9H7D0

Secondarily ID:
B2RNY0
Q5XKD5
Q6AI11
Q6PJS6
Q6ZTS6
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Ensembl ID
ENSG00000147459
HGNC ID
HGNC:23476
Subcellular Location
Cytoplasm
Cell membrane
Cell projection
Podosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0562783
 Compound Info 
7-[(3-chlorophenyl)methyl]-2-(4-methoxy-3-methylphenyl)-2,7-diazaspiro[4.4]nonan-1-one
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C22H25ClN2O2
  1
1
IC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451670
 Compound Info 
7-[(3-chlorophenyl)methyl]-2-(3-fluorophenyl)-2,7-diazaspiro[4.4]nonan-1-one
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C20H20ClFN2O
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552299
 Compound Info 
(4S,5R)-1,1-dioxo-2-phenyl-7-(quinolin-3-ylmethyl)-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C22H23N3O3S
  1
1
IC50 = 22000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552171
 Compound Info 
(4S,5R)-7-[(3-chlorophenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C19H21ClN2O3S
  1
1
IC50 = 24000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0575602
 Compound Info 
(4S,5R)-7-[(3,4-dichlorophenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C19H20Cl2N2O3S
  1
1
IC50 = 29000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0572930
 Compound Info 
(4S,5R)-7-(2,3-dihydro-1H-inden-5-ylmethyl)-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C22H26N2O3S
  1
1
IC50 = 32000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0548573
 Compound Info 
(4S,5R)-7-[(1-methylindol-3-yl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C22H25N3O3S
  1
1
IC50 = 33000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0572110
 Compound Info 
(4S,5R)-7-[(2-chlorophenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C19H21ClN2O3S
  1
1
IC50 = 35000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0572931
 Compound Info 
(4S,5R)-7-[(4-chlorophenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C19H21ClN2O3S
  1
1
IC50 = 36000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537590
 Compound Info 
(4S,5R)-7-[(3-fluoro-4-methoxyphenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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C20H23FN2O4S
  1
1
IC50 = 44000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT07580 Dedicator of cytokinesis protein 5 Mus musculus, Mouse
 Protein Info