General Information of the Compound
Compound ID
CP0537590
Compound Name
(4S,5R)-7-[(3-fluoro-4-methoxyphenyl)methyl]-1,1-dioxo-2-phenyl-1lambda6-thia-2,7-diazaspiro[4.4]nonan-4-ol
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Structure
Formula
C20H23FN2O4S
Molecular Weight
406.479
Canonical SMILES
COc1ccc(CN2CC[C@@]3(C2)[C@@H](O)CN(c2ccccc2)S3(=O)=O)cc1F
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InChI
InChI=1S/C20H23FN2O4S/c1-27-18-8-7-15(11-17(18)21)12-22-10-9-20(14-22)19(24)13-23(28(20,25)26)16-5-3-2-4-6-16/h2-8,11,19,24H,9-10,12-14H2,1H3/t19-,20+/m0/s1
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InChIKey
SJOHVIOMUHVDOJ-VQTJNVASSA-N
Physicochemical Property
logP
1.9897
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
70.08
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 139577579
ChEMBL ID
CHEMBL4795607
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07030, Dedicator of cytokinesis protein 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 44000 nM
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