General Information of the Protein
Protein ID
PT06794
Protein Name
Nuclear receptor subfamily 4 group A member 2
Secondarily
Protein Name
NUR-related factor 1
Orphan nuclear receptor NURR1
Gene Name
NR4A2
Secondarily
Gene Name
Nurr1
Sequence
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 4
>
Nuclear hormone receptor subfamily 4 group A
>
Nuclear hormone receptor subfamily 4 group A member 2
Function
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:19144721). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (PubMed:19144721).
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Uniprot ID
Primary ID:
Q06219

Secondarily ID:
O08690
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Ensembl ID
ENSG00000153234
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000020 , Neuro-2a
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0476398
 Compound Info 
N-(6-fluoropyridin-2-yl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C18H12FN5O
  1
1
EC50 = 0.6 nM
 Bioactivity Info 
   TI
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CP0423627
 Compound Info 
6-pyridin-2-yl-N-(1,3-thiazol-2-yl)imidazo[1,2-a]pyridine-2-carboxamide
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C16H11N5OS
  1
1
EC50 = 0.8 nM
 Bioactivity Info 
   TI
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CP0198133
 Compound Info 
N-phenyl-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H14N4O
  1
1
EC50 = 1 nM
 Bioactivity Info 
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CP0238190
 Compound Info 
[3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl]methanol
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C20H15ClN2O
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
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CP0423631
 Compound Info 
6-pyridin-2-yl-N-thiophen-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C17H12N4OS
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
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CP0423632
 Compound Info 
N-(2,5-difluorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H12F2N4O
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
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CP0455547
 Compound Info 
N-(2-fluorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H13FN4O
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
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CP0552486
 Compound Info 
N-(3-fluorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H13FN4O
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
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CP0476399
 Compound Info 
N-(2,3-difluorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H12F2N4O
  1
1
EC50 = 1.2 nM
 Bioactivity Info 
   TI
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CP0476402
 Compound Info 
N,6-dipyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C18H13N5O
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
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CP0549102
 Compound Info 
N-(3,5-difluorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H12F2N4O
  1
1
EC50 = 2.5 nM
 Bioactivity Info 
   TI
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CP0476401
 Compound Info 
N-(1,2-oxazol-3-yl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C16H11N5O2
  1
1
EC50 = 20 nM
 Bioactivity Info 
   TI
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CP0535360
 Compound Info 
N-(1H-pyrazol-5-yl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C16H12N6O
  1
1
EC50 = 21 nM
 Bioactivity Info 
   TI
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CP0423629
 Compound Info 
N-(2-chlorophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C19H13ClN4O
  1
1
EC50 = 26.5 nM
 Bioactivity Info 
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CP0476400
 Compound Info 
N-(1,2-oxazol-4-yl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C16H11N5O2
  1
1
EC50 = 55 nM
 Bioactivity Info 
   TI
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CP0556357
 Compound Info 
6-pyridin-2-yl-N-(1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridine-2-carboxamide
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C15H10N6OS
  1
1
EC50 = 67.6 nM
 Bioactivity Info 
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CP0535361
 Compound Info 
N-(2-cyanophenyl)-6-pyridin-2-ylimidazo[1,2-a]pyridine-2-carboxamide
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C20H13N5O
  1
1
EC50 = 292 nM
 Bioactivity Info 
   TI
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05155 Nuclear receptor subfamily 4 group A member 2 Homo sapiens, Human
 Protein Info