General Information of the Protein
Protein ID
PT06639
Protein Name
C-C chemokine receptor type 5
Gene Name
CCR5
Secondarily
Gene Name
CMKBR5
Sequence
MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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Organism
Macaca fascicularis, Crab-eating macaque, Cynomolgus monkey
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
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Uniprot ID
Primary ID:
P61814

Secondarily ID:
O02746
P79436
Q548Q9
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0405010
 Compound Info 
(2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C32H39N3O
  1
1
IC50 = 0.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405004
 Compound Info 
(2,4-dimethylpyridin-3-yl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C30H37N5O
  1
1
IC50 = 0.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405005
 Compound Info 
(2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C31H38N4O
  1
1
IC50 = 1.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525662
 Compound Info 
(2,6-dimethylphenyl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C31H38N4O
  1
1
IC50 = 1.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433169
 Compound Info 
(4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C30H37N5O
  1
1
IC50 = 2.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440545
 Compound Info 
3-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4'-methyl-[1,4']bipiperidinyl-4-yl]-phenyl-amino}-methyl)-benzonitrile
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C33H39N5O2
  1
1
IC50 = 2.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405009
 Compound Info 
(4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methylpiperidin-1-yl)(2,6-dimethylphenyl)methanone
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C33H41N3O
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454308
 Compound Info 
(3,5-dichloropyridin-4-yl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C28H31Cl2N5O
  1
1
IC50 = 3.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403557
 Compound Info 
(2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C31H38N4O2
  1
1
IC50 = 3.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440554
 Compound Info 
(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)(naphthalen-1-yl)methanone
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C33H36N4O
  1
1
IC50 = 3.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525661
 Compound Info 
(3,5-dichloro-1-oxy-pyridin-4-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C28H31Cl2N5O2
  1
1
IC50 = 4.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377973
 Compound Info 
[4-[4-(N-benzylanilino)piperidin-1-yl]-4-methylpiperidin-1-yl]-(2,4-dimethyl-1-oxidopyridin-1-ium-3-yl)methanone
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C32H40N4O2
  1
1
IC50 = 5.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036979
 Compound Info 
(2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C30H37N5O2
  2
1
IC50 = 8.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484065
 Compound Info 
(2,6-dimethylphenyl)(4-methyl-4-(4-(phenyl(pyridin-4-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C31H38N4O
  1
1
IC50 = 9.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398191
 Compound Info 
(4,6-dimethyl-1-oxy-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C30H37N5O2
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509933
 Compound Info 
(2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-2-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C30H37N5O2
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433168
 Compound Info 
(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)(3-methylpyridin-2-yl)methanone
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C29H35N5O
  1
1
IC50 = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405008
 Compound Info 
2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-methyl-thiazol-4-ylmethyl)-phenyl-amino]-[1,4']bipiperidinyl-1'-yl}-methanone
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C30H39N5O2S
  1
1
IC50 = 107 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT04523 C-C chemokine receptor type 5 Macaca mulatta, Rhesus macaque
 Protein Info 
90% Identity
Protein ID Protein Name Protein Organism
PT00903 C-C chemokine receptor type 5 Homo sapiens, Human
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT05087 C-C chemokine receptor type 5 Mus musculus, Mouse
 Protein Info