General Information of the Protein
Protein ID
PT04523
Protein Name
C-C chemokine receptor type 5
Gene Name
CCR5
Secondarily
Gene Name
CMKBR5
Sequence
MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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Organism
Macaca mulatta, Rhesus macaque
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
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Uniprot ID
Primary ID:
P61813

Secondarily ID:
O02746
P79436
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000064 , Chem-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0002124
 Compound Info 
4,4-Difluoro-cyclohexanecarboxylic acid {(S)-3-[(1S,5S)-3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-1-phenyl-propyl}-amide
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C29H41F2N5O
  1
1
Ki = 0.24 nM
 Bioactivity Info 
   TI
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CP0576676
 Compound Info 
N-[(1S)-1-[4-[[2-[2-[7-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]phenyl]-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]propyl]-4,4-difluorocyclohexane-1-carboxamide
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C64H90F2N10O10
  1
1
Ki = 2.39 nM
 Bioactivity Info 
   TI
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CP0542667
 Compound Info 
N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[7-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-4,4-difluorocyclohexane-1-carboxamide
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C65H92F2N10O10
  1
1
Ki = 3.29 nM
 Bioactivity Info 
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CP0546089
 Compound Info 
N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[9-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]nonylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-4,4-difluorocyclohexane-1-carboxamide
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C67H96F2N10O10
  1
1
Ki = 5.7 nM
 Bioactivity Info 
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CP0382274
 Compound Info 
N-[(1S)-1-(4-aminophenyl)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]propyl]-4,4-difluorocyclohexane-1-carboxamide
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C29H42F2N6O
  1
1
Ki = 15.3 nM
 Bioactivity Info 
   TI
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CP0567315
 Compound Info 
4,4-difluoro-N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[7-[[2-[2-(methylamino)-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
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C46H71F2N9O7
  1
1
Ki = 41 nM
 Bioactivity Info 
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CP0510433
 Compound Info 
4,4-difluoro-N-[(1S)-1-[4-[[2-[2-[7-[[2-[2-(methylamino)-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]phenyl]-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]propyl]cyclohexane-1-carboxamide
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C45H69F2N9O7
  1
1
Ki = 151 nM
 Bioactivity Info 
   TI
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CP0008529
 Compound Info 
US9107954, 1
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C64H90F2N10O10
  1
1
Ki = 239 nM
 Bioactivity Info 
   TI
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Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT06639 C-C chemokine receptor type 5 Macaca fascicularis, Crab-eating macaque, Cynomolgus monkey
 Protein Info 
90% Identity
Protein ID Protein Name Protein Organism
PT00903 C-C chemokine receptor type 5 Homo sapiens, Human
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT05087 C-C chemokine receptor type 5 Mus musculus, Mouse
 Protein Info