General Information of the Protein
Protein ID
PT06582
Protein Name
Parathyroid hormone/parathyroid hormone-related peptide receptor
Secondarily
Protein Name
PTH/PTHrP type I receptor
Parathyroid hormone 1 receptor
Gene Name
PTH1R
Secondarily
Gene Name
Pthr
Pthr1
Sequence
MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
>
Peptide receptor (family B GPCR)
>
Parathyroid hormone receptor
>
Parathyroid hormone receptor
Function
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
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Uniprot ID
P25961
Ensembl ID
ENSG00000160801
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000009 , LLC-PK1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0469706
 Compound Info 
US9428505, Compound 8
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C31H34F3N5O6S
  1
1
EC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474993
 Compound Info 
US9428505, Comparative: Example 1
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C26H26F3N5O6S
  1
1
EC50 = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474148
 Compound Info 
US9428505, Compound 7
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C29H32F3N5O6S
  1
1
EC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483111
 Compound Info 
US9428505, Compound 11
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C29H30F3N5O6S
  1
1
EC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483110
 Compound Info 
US9428505, Compound 10
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C29H30F3N5O7S
  1
1
EC50 = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000659 , UMR-106
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02986 Parathyroid hormone/parathyroid hormone-related peptide receptor Homo sapiens, Human
 Protein Info 
PT07326 Parathyroid hormone/parathyroid hormone-related peptide receptor Mus musculus, Mouse
 Protein Info