General Information of the Protein
Protein ID
PT06423
Protein Name
Beta-3 adrenergic receptor
Secondarily
Protein Name
Beta-3 adrenoreceptor
Gene Name
ADRB3
Secondarily
Gene Name
B3AR
Sequence
MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIVAITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRWELGRFPPEESSPALSRSLAPAPAGTCAPPEGVPACCRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPDPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCHCGGRLPREPCAADRPASSPRAPLRPGPAPRSPGFASGSTGLLGEFLRPEGQEATLR
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Organism
Macaca mulatta, Rhesus macaque
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
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Uniprot ID
Q28524
Ensembl ID
ENSG00000188778
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0135429
 Compound Info 
(4R)-2-amino-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
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C25H28N4O2S
  1
1
EC50 = 0.06 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0156740
 Compound Info 
(R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide
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C31H27F3N4O3S2
  2
1
EC50 = 0.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0105650
 Compound Info 
KRP-114V
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C26H28N4O3
  2
1
EC50 = 0.57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 7.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0135426
 Compound Info 
(4R)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
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C24H26N4O2S
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0156745
 Compound Info 
(2S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)propanamide
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C25H28N4O3
  2
1
EC50 = 2.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0105652
 Compound Info 
N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)acetamide
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C24H26N4O3
  1
1
EC50 = 3.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0105651
 Compound Info 
(6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide
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C24H27N5O2
  1
1
EC50 = 4.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01493 Beta-3 adrenergic receptor Homo sapiens, Human
 Protein Info 
PT04360 Beta-3 adrenergic receptor Rattus norvegicus, Rat
 Protein Info 
PT06057 Beta-3 adrenergic receptor Canis lupus familiaris, Dog, Canis familiaris
 Protein Info