General Information of the Protein
Protein ID
PT06354
Protein Name
Solute carrier family 40 member 1
Secondarily
Protein Name
Ferroportin-1
Iron-regulated transporter 1
Metal transporter protein 1
Gene Name
SLC40A1
Secondarily
Gene Name
Fpn1
Ireg1
Slc11a3
Slc39a1
Sequence
MTKARDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKNELLTMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIVVVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIRELECEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFVNVEPVSPTTKIPETVFTTEMHMSNMSNVHEMSTKPIPIVSVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCGPDEKEVTDENQPNTSVV
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC40 iron transporter
Function
Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:16054062, PubMed:30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PubMed:16054062, PubMed:30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity).
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Uniprot ID
Primary ID:
Q9JHI9

Secondarily ID:
Q3UHZ9
Q8BME5
Q8BUM5
Q9JIM9
Q9JKP4
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Ensembl ID
ENSG00000138449
Subcellular Location
Cell membrane
Basolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000158 , J774
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0874591
 Compound Info 
2-(2-{bis[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C30H29FN8OS
  1
1
IC50 = 4 nM
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CP0887768
 Compound Info 
2-(2-{bis[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide tetrahydrochloride
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C30H33Cl4FN8O2
  1
1
IC50 = 5 nM
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CP0874581
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-chloropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H21ClN6O2
  1
1
IC50 = 6 nM
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CP0947240
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-chloropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19ClN6OS
  1
1
IC50 = 6 nM
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CP0942114
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-5-chloro-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H23Cl4FN6OS
  1
1
IC50 = 8.3 nM
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CP0903120
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide trihydrochloride
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C21H24Cl3FN6O2
  1
1
IC50 = 9 nM
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CP0874586
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 10 nM
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CP0880270
 Compound Info 
1-(2-((2-(1H-benzo[d]imidazol-2-yl)ethyl)amino)ethyl)-N-((3-fluoropyridin-2-yl)methyl)-1H-1,2,3-triazole-4-carboxamide
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C20H21FN8O
  1
1
IC50 = 11 nM
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CP0874584
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-chloropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C21H22ClN7O
  1
1
IC50 = 12 nM
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CP0901637
 Compound Info 
2-{1-[2-(1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C22H21FN6O2
  1
1
IC50 = 12 nM
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CP0901639
 Compound Info 
2-(2-{[2-(1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H21FN6OS
  1
1
IC50 = 12 nM
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CP0903140
 Compound Info 
2-(2-{[2-(1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-5-carboxamide
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C21H21FN6O2
  1
1
IC50 = 12 nM
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CP0880267
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-methylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H25Cl3N6OS
  1
1
IC50 = 15 nM
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CP0946477
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-methylpyridin-4-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H25Cl3N6OS
  1
1
IC50 = 25 nM
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CP0903146
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyridin-2-ylmethyl)-1,3-oxazole-4-carboxamide trihydrochloride
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C21H25Cl3N6O2
  1
1
IC50 = 26 nM
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CP0904080
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyridazin-3-ylmethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C20H24Cl3N7OS
  1
1
IC50 = 26 nM
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CP0948408
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(1,3-oxazol-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C18H18N6O2S
  1
1
IC50 = 29 nM
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CP0854890
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(5,6,7,8-tetrahydroquinolin-8-yl)-1,3-thiazole-4-carboxamide
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C23H24N6OS
  1
1
IC50 = 30 nM
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CP0903122
 Compound Info 
2-(2-{[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H20F2N6OS
  1
1
IC50 = 32 nM
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CP0904081
 Compound Info 
2-(2-{[2-(5-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H23Cl3F2N6OS
  1
1
IC50 = 34 nM
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CP0874587
 Compound Info 
2-(2-{[2-(4,5-Difluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H19F3N6O2
  1
1
IC50 = 35 nM
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CP0887766
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-5-carboxamide
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C22H21FN6O2
  1
1
IC50 = 35 nM
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CP0903130
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide tetrahydrochloride
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C21H26Cl4FN7O
  1
1
IC50 = 35 nM
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CP0903142
 Compound Info 
2-{1-[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C22H20F2N6O2
  1
1
IC50 = 36 nM
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CP0880284
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoro-6-methylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H21FN6OS
  1
1
IC50 = 37 nM
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CP0903753
 Compound Info 
2-(2-{[2-(4,6-Difluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H19F3N6O2
  1
1
IC50 = 40 nM
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CP0874588
 Compound Info 
2-(2-{[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H20F2N6O2
  1
1
IC50 = 46 nM
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CP0958111
 Compound Info 
2-(2-(2-(1H-benzo[d]imidazol-2-yl)ethylamino)ethyl)-N-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)thiazole-4-carboxamide
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C23H24N6OS
  1
1
IC50 = 47 nM
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CP0874577
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C20H22Cl3FN6OS
  1
1
IC50 = 49 nM
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CP0903127
 Compound Info 
2-(2-{[2-(4-Chloro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H20ClFN6O2
  1
1
IC50 = 49 nM
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CP0954546
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-methoxypyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6O2S
  1
1
IC50 = 50 nM
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CP0955513
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-chloro-5-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H18ClFN6OS
  1
1
IC50 = 58 nM
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CP0909892
 Compound Info 
5-chloro-N-(pyridin-2-ylmethyl)-2-(2-{1,8,12-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-yl}ethyl)-1,3-thiazole-4-carboxamide
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C22H21ClN6OS
  1
1
IC50 = 60 nM
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CP0957856
 Compound Info 
2-(2-{[2-(4,7-Difluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H19F3N6O2
  1
1
IC50 = 62 nM
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CP0871743
 Compound Info 
2-{1-[2-(5-fluoro-1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-5-carboxamide
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C22H20F2N6O2
  1
1
IC50 = 63 nM
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CP0947239
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-5-chloro-N-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C21H21ClN6OS
  1
1
IC50 = 63 nM
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CP0874579
 Compound Info 
2-(2-{[2-(5-cyano-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C22H20FN7O2
  1
1
IC50 = 70 nM
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CP0903748
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{5H,6H,7H-cyclopenta[b]pyridin-7-yl}-1,3-thiazole-4-carboxamide trihydrochloride
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C22H25Cl3N6OS
  1
1
IC50 = 70 nM
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CP0880280
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-4-carboxamide
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C21H23N7O
  1
1
IC50 = 76 nM
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CP0944109
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(4,6-dimethylpyridin-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H24N6OS
  1
1
IC50 = 77 nM
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CP0903750
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C20H23Cl3N6OS
  1
1
IC50 = 80 nM
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CP0903121
 Compound Info 
N-[(3-fluoropyridin-2-yl)methyl]-2-[2-({2-[4-(trifluoromethyl)-1H-1,3-benzodiazol-2-yl]ethyl}amino)ethyl]-1,3-oxazole-4-carboxamide
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C22H20F4N6O2
  1
1
IC50 = 81 nM
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CP0951408
 Compound Info 
2-(2-{[2-(7-Chloro-4-fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H19ClF2N6O2
  1
1
IC50 = 82 nM
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CP0941165
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-4-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 89 nM
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CP0887764
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-{5H,6H,7H-cyclopenta[b]pyridin-7-yl}-1H-pyrazole-4-carboxamide trihydrochloride
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C23H28Cl3N7O
  1
1
IC50 = 90 nM
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CP0944213
 Compound Info 
2-{1-[2-(1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-(pyridazin-3-ylmethyl)-1,3-oxazole-4-carboxamide
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C21H21N7O2
  1
1
IC50 = 90 nM
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CP0905660
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-[(3-chloropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H18Cl2N6OS
  1
1
IC50 = 91 nM
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CP0941166
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-oxo-1,2-dihydropyridin-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H20N6O2S
  1
1
IC50 = 96 nM
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CP0946518
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide trihydrochloride
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C20H22Cl3FN6O2
  1
1
IC50 = 96 nM
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CP0850093
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3,5-dimethylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H24N6OS
  1
1
IC50 = 100 nM
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CP0944108
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-5-methyl-1,3-thiazole-4-carboxamide
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C22H23FN6OS
  1
1
IC50 = 100 nM
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CP0874594
 Compound Info 
2-({[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C20H22Cl3FN6OS
  1
1
IC50 = 103 nM
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CP0942115
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H18ClFN6OS
  1
1
IC50 = 111 nM
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CP0905657
 Compound Info 
2-(2-{[(6-Fluoro-1H-1,3-benzodiazol-2-yl)methyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C20H21Cl3F2N6OS
  1
1
IC50 = 118 nM
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CP0951409
 Compound Info 
N-[(3-fluoropyridin-2-yl)methyl]-2-(2-{[2-(4-methoxy-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-1,3-oxazole-4-carboxamide
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C22H23FN6O3
  1
1
IC50 = 130 nM
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CP0951422
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1-methyl-1H-imidazol-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C19H21N7OS
  1
1
IC50 = 130 nM
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CP0957785
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3,5-difluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H18F2N6OS
  1
1
IC50 = 130 nM
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CP0903128
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-5-chloro-N-(pyridazin-3-ylmethyl)-1,3-thiazole-4-carboxamide
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C20H20ClN7OS
  1
1
IC50 = 131 nM
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CP0903755
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1H-1,2,4-triazole-3-carboxamide
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C20H21FN8O
  1
1
IC50 = 135 nM
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CP0880273
 Compound Info 
2-(2-{[2-(5-fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C21H20F2N6O2
  1
1
IC50 = 140 nM
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CP0909890
 Compound Info 
2-(2-(2-(1H-benzo[d]imidazol-2-yl)ethylamino)ethyl)-N-((3-fluoropyridin-2-yl)methyl)-5-methyloxazole-4-carboxamide
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C22H23FN6O2
  1
1
IC50 = 140 nM
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CP0909886
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(6-methylpyridazin-3-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H26Cl3N7OS
  1
1
IC50 = 141 nM
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CP0874590
 Compound Info 
1-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C22H22FN7O
  1
1
IC50 = 145 nM
 Bioactivity Info 
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CP0957855
 Compound Info 
2-(2-{[(4-fluoro-1H-1,3-benzodiazol-2-yl)methyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H18F2N6OS
  1
1
IC50 = 145 nM
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CP0874580
 Compound Info 
2-(2-{[2-(4-fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyridin-2-ylmethyl)-1,3-oxazole-4-carboxamide
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C21H21FN6O2
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0880272
 Compound Info 
2-{1-[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-(pyridin-2-ylmethyl)-1,3-oxazole-4-carboxamide
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C22H21FN6O2
  1
1
IC50 = 152 nM
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CP0900251
 Compound Info 
2-{2-[(1H-1,3-benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-5-carboxamide
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C20H19FN6O2
  1
1
IC50 = 155 nM
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CP0960692
 Compound Info 
2-({[3-(1H-1,3-Benzodiazol-2-yl)propyl]amino}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H24Cl3FN6OS
  1
1
IC50 = 164 nM
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CP0951377
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-chloropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C20H19ClN6O2
  1
1
IC50 = 167 nM
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CP0900252
 Compound Info 
2-{1-[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-5-carboxamide
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C22H20F2N6O2
  1
1
IC50 = 170 nM
 Bioactivity Info 
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CP0909889
 Compound Info 
N-[(3,5-Difluoropyridin-2-yl)methyl]-2-(2-{[2-(5-fluoro-1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C21H22Cl3F3N6OS
  1
1
IC50 = 170 nM
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CP0951417
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-chloropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C20H20ClN7O
  1
1
IC50 = 179 nM
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CP0874589
 Compound Info 
2-({[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C20H19FN6O2
  1
1
IC50 = 180 nM
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CP0905659
 Compound Info 
2-{1-[2-(1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-(pyridin-2-ylmethyl)-1,3-oxazole-4-carboxamide
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C22H22N6O2
  1
1
IC50 = 183 nM
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CP0903683
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridin-3-ylmethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C20H23Cl3N6OS
  1
1
IC50 = 190 nM
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CP0944236
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridazin-3-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H19N7OS
  1
1
IC50 = 190 nM
 Bioactivity Info 
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CP0946468
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-chloropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H21ClN6OS
  1
1
IC50 = 210 nM
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CP0959707
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(difluoromethoxy)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C22H21F2N5O2S
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0903124
 Compound Info 
Benzyl N-(3-{[2-(1H-1,3-benzodiazol-2-yl)ethyl][2-(4-{[(3-fluoropyridin-2-yl)methyl]carbamoyl}-1,3-thiazol-2-yl)ethyl]amino}propyl)carbamate
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C32H34FN7O3S
  1
1
IC50 = 216 nM
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CP0901638
 Compound Info 
2-(2-{[(4-fluoro-1H-1,3-benzodiazol-2-yl)methyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C20H18F2N6O2
  1
1
IC50 = 226 nM
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CP0880271
 Compound Info 
N-[(3-Fluoropyridin-2-yl)methyl]-2-(1-{2-[7-(trifluoromethyl)-1H-1,3-benzodiazol-2-yl]ethyl}azetidin-3-yl)-1,3-oxazole-4-carboxamide
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C23H20F4N6O2
  1
1
IC50 = 228 nM
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CP0903762
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-5-carboxamide
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C21H21FN6OS
  1
1
IC50 = 240 nM
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CP0941149
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-cyanophenyl)methyl]-1,3-thiazole-4-carboxamide
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C22H20N6OS
  1
1
IC50 = 240 nM
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CP0941150
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridin-4-ylmethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C20H23Cl3N6OS
  1
1
IC50 = 250 nM
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CP0959235
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(5-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 250 nM
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CP0903109
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C20H19ClN6OS
  1
1
IC50 = 256 nM
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CP0959710
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2,6-difluorophenyl)methyl]-1,3-thiazole-4-carboxamide
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C21H19F2N5OS
  1
1
IC50 = 260 nM
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CP0941164
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(5-methylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 270 nM
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CP0903132
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-1,3-thiazole-4-carboxamide
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C21H18ClF3N6OS
  1
1
IC50 = 280 nM
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CP0880276
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H21FN6OS
  1
1
IC50 = 287 nM
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CP0905658
 Compound Info 
3-({[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1-methyl-1H-pyrazole-5-carboxamide
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C21H22FN7O
  1
1
IC50 = 290 nM
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CP0874583
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide
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C22H21F4N7O
  1
1
IC50 = 297 nM
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CP0942112
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-5-(trifluoromethyl)-1,3-thiazole-4-carboxamide
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C22H20F4N6OS
  1
1
IC50 = 300 nM
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CP0903144
 Compound Info 
1-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-{5H,6H,7H-cyclopenta[b]pyridin-7-yl}-1H-pyrazole-4-carboxamide
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C24H25N7O
  1
1
IC50 = 330 nM
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CP0903125
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-5-methyl-1,3-thiazole-4-carboxamide
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C21H21FN6OS
  1
1
IC50 = 343 nM
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CP0960696
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[1-(pyridin-2-yl)ethyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 345 nM
 Bioactivity Info 
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CP0909893
 Compound Info 
2-(2-{[2-(1H-1,3-benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(5-methylpyrimidin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H26Cl3N7OS
  1
1
IC50 = 347 nM
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CP0880286
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(3-fluoropyridin-2-yl)-1,3-thiazole-4-carboxamide
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C19H17FN6OS
  1
1
IC50 = 350 nM
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CP0874593
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-(pyrimidin-2-ylmethyl)-1,3-thiazole-4-carboxamide trihydrochloride
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C20H24Cl3N7OS
  1
1
IC50 = 353 nM
 Bioactivity Info 
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CP0850092
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[2-(pyridin-2-yl)ethyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 360 nM
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CP0960686
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-(pyridazin-3-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H18ClN7OS
  1
1
IC50 = 361 nM
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CP0887767
 Compound Info 
4-({[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-2-carboxamide
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C20H19FN6OS
  1
1
IC50 = 370 nM
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CP0874592
 Compound Info 
2-{3-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]propyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H24Cl3FN6OS
  1
1
IC50 = 377 nM
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CP0903110
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl](methyl)amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C22H26Cl3FN6OS
  1
1
IC50 = 378 nM
 Bioactivity Info 
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CP0944105
 Compound Info 
2-{1-[2-(1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-5-chloro-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H20ClFN6OS
  1
1
IC50 = 379 nM
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CP0909887
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C20H20FN7O
  1
1
IC50 = 385 nM
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CP0887769
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1-methyl-1H-imidazol-5-yl)methyl]-1,3-thiazole-4-carboxamide
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C19H21N7OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0903751
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
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C22H23FN6OS
  1
1
IC50 = 400 nM
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CP0877275
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(6-cyanopyridin-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H19N7OS
  1
1
IC50 = 410 nM
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CP0957786
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}-1,3-thiazole-4-carboxamide
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C21H19F3N6OS
  1
1
IC50 = 420 nM
 Bioactivity Info 
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CP0944217
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(5-methoxypyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6O2S
  1
1
IC50 = 440 nM
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CP0880269
 Compound Info 
5-{[(2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-1,3-thiazol-4-yl)formamido]methyl}pyridine-2-carboxamide
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C21H21N7O2S
  1
1
IC50 = 460 nM
 Bioactivity Info 
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CP0903147
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H23N7OS
  1
1
IC50 = 460 nM
 Bioactivity Info 
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CP0907044
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-yl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide dihydrochloride
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C19H19Cl2FN6OS
  1
1
IC50 = 473 nM
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CP0871793
 Compound Info 
5-(2-((2-(1H-benzo[d]imidazol-2-yl)ethyl)amino)ethyl)-N-(pyridin-2-ylmethyl)-1,2,4-oxadiazole-3-carboxamide
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C20H21N7O2
  1
1
IC50 = 476 nM
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CP0874595
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1-methyl-1H-pyrazol-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C19H21N7OS
  1
1
IC50 = 480 nM
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CP0957783
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-chloropyridin-2-yl)methyl]-1H-1,2,4-triazole-3-carboxamide
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C19H19ClN8O
  1
1
IC50 = 482 nM
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CP0887763
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridine-2-ylmethyl)-1,3-oxazole-4-carboxamid
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C20H20N6O2
  1
1
IC50 = 514 nM
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CP0871769
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(morpholine-4-sulfonyl)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C25H28N6O4S2
  1
1
IC50 = 530 nM
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CP0903133
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(6-methylpyridazin-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H21N7OS
  1
1
IC50 = 530 nM
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CP0903760
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(dimethylamino)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C23H26N6OS
  1
1
IC50 = 530 nM
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CP0947256
 Compound Info 
2-{1-[2-(4-Fluoro-1H-1,3-benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-(pyridazin-3-ylmethyl)-1,3-oxazole-4-carboxamide
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C21H20FN7O2
  1
1
IC50 = 554 nM
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CP0904108
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyrimidin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H19N7OS
  1
1
IC50 = 560 nM
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CP0944214
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{5H,6H,7H-cyclopenta[b]pyridin-7-yl}-1H-pyrazole-4-carboxamide
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C22H23N7O
  1
1
IC50 = 580 nM
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CP0874576
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyrazin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H19N7OS
  1
1
IC50 = 590 nM
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CP0903141
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(6-methylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 600 nM
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CP0961170
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(morpholin-4-yl)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C25H28N6O2S
  1
1
IC50 = 610 nM
 Bioactivity Info 
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CP0938647
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl](butyl)amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C25H29FN6OS
  1
1
IC50 = 717 nM
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CP0909891
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}-N-{5H,6H,7H-cyclopenta[b]pyridin-7-yl}-1,3-thiazole-4-carboxamide
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C24H24N6OS
  1
1
IC50 = 720 nM
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CP0959712
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(6-oxo-1,6-dihydropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H20N6O2S
  1
1
IC50 = 720 nM
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CP0909885
 Compound Info 
2-{1-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-3-hydroxyazetidin-3-yl}-5-chloro-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H20ClFN6O2S
  1
1
IC50 = 747 nM
 Bioactivity Info 
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CP0903129
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1H-1,2,4-triazole-3-carboxamide
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C19H19FN8O
  1
1
IC50 = 750 nM
 Bioactivity Info 
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CP0880283
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1-methyl-1H-pyrazol-5-yl)methyl]-1,3-thiazole-4-carboxamide
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C19H21N7OS
  1
1
IC50 = 780 nM
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CP0903123
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)-2-methylpropyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C23H25FN6OS
  1
1
IC50 = 780 nM
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CP0854891
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1,3-thiazole-4-carboxamide
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C21H19F3N6OS
  1
1
IC50 = 810 nM
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CP0954513
 Compound Info 
2-{2-[(3-Aminopropyl)[2-(1H-1,3-benzodiazol-2-yl)ethyl]amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C24H28FN7OS
  1
1
IC50 = 828 nM
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CP0903134
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyridin-2-ylmethyl)-1H-pyrazole-4-carboxamide
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C20H21N7O
  1
1
IC50 = 830 nM
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CP0903681
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-fluorophenyl)methyl]-1,3-thiazole-4-carboxamide
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C21H20FN5OS
  1
1
IC50 = 850 nM
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CP0947257
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-methoxypyridin-4-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6O2S
  1
1
IC50 = 900 nM
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CP0969572
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(thiophen-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H19N5OS2
  1
1
IC50 = 900 nM
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CP0903145
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-5-(trifluoromethyl)-1,3-thiazole-4-carboxamide
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C21H18F4N6OS
  1
1
IC50 = 957 nM
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CP0942113
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-5-chloro-N-[(5-methylpyrimidin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22ClN7OS
  1
1
IC50 = 989 nM
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CP0905656
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3,5-difluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C21H23Cl3F2N6OS
  1
1
IC50 = 1000 nM
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CP0903756
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-(pyrimidin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H18ClN7OS
  1
1
IC50 = 1025 nM
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CP0874582
 Compound Info 
2-{2-[bis(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C28H25FN8OS
  1
1
IC50 = 1118 nM
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CP0903108
 Compound Info 
4-(2-{[2-(1H-1,3-Benzodiazol-2-yl)-2,2-difluoroethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-2-carboxamide
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C21H19F3N6OS
  1
1
IC50 = 1130 nM
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CP0880277
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-5-methyl-N-(pyrimidin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C21H23N7OS
  1
1
IC50 = 1160 nM
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CP0874540
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(pyrimidin-4-ylmethyl)-1,3-thiazole-4-carboxamide
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C19H19N7OS
  1
1
IC50 = 1330 nM
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CP0959708
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(trifluoromethoxy)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C22H20F3N5O2S
  1
1
IC50 = 1360 nM
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CP0941163
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(4-methylpyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 1520 nM
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CP0951544
 Compound Info 
2-(2-{[3-(1H-1,3-Benzodiazol-2-yl)propyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C22H26Cl3FN6OS
  1
1
IC50 = 1660 nM
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CP0951545
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[3-(hydroxymethyl)pyridin-2-yl]methyl}-1,3-thiazole-4-carboxamide
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C21H22N6O2S
  1
1
IC50 = 1699 nM
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CP0880282
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[6-(dimethylamino)pyridin-3-yl]methyl}-1,3-thiazole-4-carboxamide
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C22H25N7OS
  1
1
IC50 = 1850 nM
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CP0904079
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl](methyl)amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C22H23FN6O2
  1
1
IC50 = 1900 nM
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CP0854892
 Compound Info 
5-(2-((2-(1H-benzo[d]imidazol-2-yl)ethyl)amino)ethyl)-N-((3-fluoropyridin-2-yl)methyl)-1,2,4-oxadiazole-3-carboxamide
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C20H20FN7O2
  1
1
IC50 = 2009 nM
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CP0948455
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1,3-thiazole-4-carboxamide
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C19H21N7OS
  1
1
IC50 = 2070 nM
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CP0960687
 Compound Info 
2-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl](cyclopropylmethyl)amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C25H27FN6OS
  1
1
IC50 = 2085 nM
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CP0955512
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-fluoropyridin-3-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 2370 nM
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CP0944216
 Compound Info 
N-(1H-1,3-Benzodiazol-2-ylmethyl)-2-{2-[(1H-1,3-benzodiazol-2-ylmethyl)amino]ethyl}-1,3-thiazole-4-carboxamide
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C22H21N7OS
  1
1
IC50 = 2390 nM
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CP0960688
 Compound Info 
1-(2-{[2-(1H-1,3-Benzodiazol-2-yl)ethyl]amino}ethyl)-N-[(3-fluoropyridin-2-yl)methyl]-5-methyl-1H-imidazole-4-carboxamide
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C22H24FN7O
  1
1
IC50 = 2430 nM
 Bioactivity Info 
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CP0880279
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide
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C21H19F4N7O
  1
1
IC50 = 2462 nM
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CP0953916
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(4-methylpiperazin-1-yl)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C26H31N7OS
  1
1
IC50 = 2500 nM
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CP0947244
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(morpholin-4-yl)pyridin-4-yl]methyl}-1,3-thiazole-4-carboxamide
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C24H27N7O2S
  1
1
IC50 = 2970 nM
 Bioactivity Info 
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CP0880281
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(2-methylpyridin-4-yl)methyl]-1,3-thiazole-4-carboxamide
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C21H22N6OS
  1
1
IC50 = 2990 nM
 Bioactivity Info 
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CP0941162
 Compound Info 
2-{3-[(1H-1,3-Benzodiazol-2-yl)amino]propyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 3407 nM
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CP0944107
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-5-chloro-N-[(5-methylpyrimidin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H20ClN7OS
  1
1
IC50 = 3637 nM
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CP0909888
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-5-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide 2-{2-[(1H-1,3-Benzodiazol-4-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 3727 nM
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CP0957782
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-5-(prop-1-en-2-yl)-1,3-thiazole-4-carboxamide
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C23H23FN6OS
  1
1
IC50 = 4203 nM
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CP0942110
 Compound Info 
2-[(1R,5S,6S)-3-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-3-azabicyclo[3.1.0]hexan-6-yl]-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C24H23FN6OS
  1
1
IC50 = 4500 nM
 Bioactivity Info 
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CP0874585
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-5-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C20H19FN6OS
  1
1
IC50 = 4794 nM
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CP0942111
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1-methyl-1H-imidazole-4-carboxamide
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C21H22FN7O
  1
1
IC50 = 4913 nM
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CP0957776
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]-2-methylpropyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C22H23FN6OS
  1
1
IC50 = 5200 nM
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CP0942117
 Compound Info 
2-({[3-(1H-1,3-Benzodiazol-2-yl)propyl]amino}methyl)-N-[(3,5-difluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide dihydrochloride
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C21H22Cl2F2N6OS
  1
1
IC50 = 6332 nM
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CP0953918
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-{[2-(pyrrolidin-1-yl)phenyl]methyl}-1,3-thiazole-4-carboxamide
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C25H28N6OS
  1
1
IC50 = 6700 nM
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CP0960693
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-(1H-imidazol-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C18H19N7OS
  1
1
IC50 = 7230 nM
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CP0880274
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-3-methylazetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
   Show/Hide
C23H23FN6OS
  1
1
IC50 = 8514 nM
 Bioactivity Info 
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CP0944293
 Compound Info 
2-(1-{[2-(1H-1,3-benzodiazol-2-yl)ethyl]amino}-2-methylpropan-2-yl)-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide
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C23H25FN6OS
  1
1
IC50 = 8920 nM
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CP0887765
 Compound Info 
1-({[2-(1H-1,3-Benzodiazol-2-yl)ethyl]carbamoyl}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide dihydrochloride
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C21H22Cl2FN7O2
  1
1
IC50 = 9695 nM
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CP0941151
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-methyl-N-phenyl-1,3-thiazole-4-carboxamide
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C21H21N5OS
  1
1
IC50 = 10000 nM
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CP0942116
 Compound Info 
1-[1-(1H-1,3-Benzodiazol-2-ylmethyl)azetidin-3-yl]-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C21H20FN7O
  1
1
IC50 = 10490 nM
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CP0944106
 Compound Info 
1-({1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]azetidin-3-yl}methyl)-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C23H24FN7O
  1
1
IC50 = 13560 nM
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CP0944294
 Compound Info 
2-(1-(2-(1H-benzo[d]imidazol-2-yl)ethyl)pyrrolidin-3-yl)-N-((3-fluoropyridin-2-yl)methyl)thiazole-4-carboxamide
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C23H23FN6OS
  1
1
IC50 = 14100 nM
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CP0903754
 Compound Info 
2-{1-[3-(1H-1,3-Benzodiazol-2-yl)propyl]azetidin-3-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide
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C23H23FN6O2
  1
1
IC50 = 16000 nM
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CP0903126
 Compound Info 
1-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide
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C22H24FN7O
  1
1
IC50 = 21606 nM
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CP0912267
 Compound Info 
2-{2-[(1,3-Benzoxazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide trihydrochloride
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C20H21Cl3FN5O2S
  1
1
IC50 = 25000 nM
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CP0954514
 Compound Info 
2-{2-[2-(1H-1,3-Benzodiazol-2-yl)acetamido]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-1,3-thiazole-4-carboxamide dihydrochloride
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C21H21Cl2FN6O2S
  1
1
IC50 = 25000 nM
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CP0957328
 Compound Info 
N-[(3-fluoropyridin-2-yl)methyl]-2-(2-{12-oxo-1,8,11-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-11-yl}ethyl)-1,3-thiazole-4-carboxamide
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C22H19FN6O2S
  1
1
IC50 = 26035 nM
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CP0880275
 Compound Info 
1-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]piperidin-4-yl}-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C24H26FN7O
  1
1
IC50 = 27050 nM
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CP0944104
 Compound Info 
N-[(3-fluoropyridin-2-yl)methyl]-2-(2-{1,8,11-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-11-yl}ethyl)-1,3-thiazole-4-carboxamide
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C22H21FN6OS
  1
1
IC50 = 27160 nM
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CP0903143
 Compound Info 
2-{1-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]pyrrolidin-3-yl}-N-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide
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C23H24N6OS
  1
1
IC50 = 27700 nM
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CP0953917
 Compound Info 
6-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-N-(pyridin-2-ylmethyl)-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxamide
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C23H23N5OS
  1
1
IC50 = 30580 nM
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CP0880278
 Compound Info 
2-{2-[(1H-1,3-Benzodiazol-2-ylmethyl)amino]ethyl}-N-[(3-fluoropyridin-2-yl)methyl]-5-(propan-2-yl)-1,3-thiazole-4-carboxamide
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C23H25FN6OS
  1
1
IC50 = 30855 nM
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CP0871792
 Compound Info 
2-(1-((1H-benzo[d]imidazol-2-yl)methyl)azetidin-3-yl)-N-((3-fluoropyridin-2-yl)methyl)oxazole-5-carboxamide
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C21H19FN6O2
  1
1
IC50 = 50000 nM
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CP0960691
 Compound Info 
1-{[1-(1H-1,3-Benzodiazol-2-ylmethyl)azetidin-3-yl]methyl}-N-[(3-fluoropyridin-2-yl)methyl]-1H-pyrazole-4-carboxamide
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C22H22FN7O
  1
1
IC50 = 87000 nM
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06104 Solute carrier family 40 member 1 Homo sapiens, Human
 Protein Info