General Information of the Protein
Protein ID
PT06266
Protein Name
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Secondarily
Protein Name
Iron-sulfur subunit of complex II
Gene Name
SDHB
Secondarily
Gene Name
SDH
SDH1
Sequence
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
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Uniprot ID
Primary ID:
P21912

Secondarily ID:
B2R545
Q0QEY7
Q9NQ12
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Ensembl ID
ENSG00000117118
HGNC ID
HGNC:10681
Subcellular Location
Mitochondrion inner membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0381100
 Compound Info 
N-(1-adamantyl)-4-[4-[1-[(3,4-dimethoxyphenyl)methyl]-6-oxopyridin-3-yl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylbutanamide
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C33H37F3N4O6S
  2
1
EC50 = 0.23 nM
 Bioactivity Info 
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2
EC50 = 0.42 nM
 Bioactivity Info 
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CP0575524
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-(4-oxo-4-piperidin-1-ylbutyl)sulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C28H31F3N4O6S
  1
1
EC50 = 1.4 nM
 Bioactivity Info 
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CP0454817
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C20H18F3N3O5S
  1
1
EC50 = 25 nM
 Bioactivity Info 
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CP0517800
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-(4-oxo-4-pyrrolidin-1-ylbutyl)sulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C27H29F3N4O6S
  1
1
EC50 = 27 nM
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CP0410371
 Compound Info 
1-[(3-methoxyphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C19H16F3N3O4S
  1
1
EC50 = 57 nM
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CP0429085
 Compound Info 
1-[(4-chlorophenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C18H13ClF3N3O3S
  1
1
EC50 = 66 nM
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CP0536288
 Compound Info 
5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]-1-[(3-propoxyphenyl)methyl]pyridin-2-one
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C21H20F3N3O4S
  1
1
EC50 = 69 nM
 Bioactivity Info 
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CP0414857
 Compound Info 
1-[(4-methoxyphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C19H16F3N3O4S
  1
1
EC50 = 94 nM
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CP0457337
 Compound Info 
1-[(3-ethoxyphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C20H18F3N3O4S
  1
1
EC50 = 110 nM
 Bioactivity Info 
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CP0517801
 Compound Info 
4-[4-[1-[(3,4-dimethoxyphenyl)methyl]-6-oxopyridin-3-yl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonyl-N,N-dimethylbutanamide
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C25H27F3N4O6S
  1
1
EC50 = 164 nM
 Bioactivity Info 
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CP0575526
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-(2-methoxyethylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C22H22F3N3O6S
  1
1
EC50 = 216 nM
 Bioactivity Info 
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CP0566928
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-heptylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C26H30F3N3O5S
  1
1
EC50 = 253 nM
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CP0399967
 Compound Info 
1-[(3-chlorophenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C18H13ClF3N3O3S
  1
1
EC50 = 257 nM
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CP0575525
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-(3-methoxypropylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C23H24F3N3O6S
  1
1
EC50 = 282 nM
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CP0457335
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-5-[2-pentylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C24H26F3N3O5S
  1
1
EC50 = 364 nM
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CP0221655
 Compound Info 
2-(methylsulfonyl)-4-thien-2-yl-6-(trifluoromethyl)pyrimidine
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C10H7F3N2O2S2
  1
1
EC50 = 749 nM
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CP0457336
 Compound Info 
1-[(4-ethynylphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C20H14F3N3O3S
  1
1
EC50 = 817 nM
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CP0454818
 Compound Info 
ethyl 3-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylpropanoate
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C14H13F3N2O4S2
  1
1
EC50 = 1135 nM
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CP0399968
 Compound Info 
1-[(2-chlorophenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C18H13ClF3N3O3S
  1
1
EC50 = 1143 nM
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CP0399969
 Compound Info 
1-benzyl-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C18H14F3N3O3S
  1
1
EC50 = 1157 nM
 Bioactivity Info 
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CP0539039
 Compound Info 
2-ethylsulfonyl-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine
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C11H9F3N2O2S2
  1
1
EC50 = 1428 nM
 Bioactivity Info 
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CP0492750
 Compound Info 
2-(2-phenylethylsulfonyl)-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine
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C17H13F3N2O2S2
  1
1
EC50 = 1591 nM
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CP0575896
 Compound Info 
1-[(3-hydroxyphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C18H14F3N3O4S
  1
1
EC50 = 1821 nM
 Bioactivity Info 
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CP0375301
 Compound Info 
2-(methylsulfonyl)-4-phenyl-6-(trifluoromethyl)pyrimidine
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C12H9F3N2O2S
  1
1
EC50 = 2201 nM
 Bioactivity Info 
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CP0575529
 Compound Info 
4-(3-methylphenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
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C13H11F3N2O2S
  1
1
EC50 = 3487 nM
 Bioactivity Info 
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CP0488439
 Compound Info 
4-[[5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]-2-oxopyridin-1-yl]methyl]benzonitrile
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C19H13F3N4O3S
  1
1
EC50 = 3489 nM
 Bioactivity Info 
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CP0429087
 Compound Info 
methyl 3-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]benzoate
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C14H11F3N2O4S
  1
1
EC50 = 3516 nM
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CP0429089
 Compound Info 
N-(2-hydroxy-5-methylphenyl)-4-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylbutanamide
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C20H18F3N3O4S2
  1
1
EC50 = 4000 nM
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CP0575527
 Compound Info 
3-[[5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]-2-oxopyridin-1-yl]methyl]benzonitrile
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C19H13F3N4O3S
  1
1
EC50 = 4060 nM
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CP0457338
 Compound Info 
2-[(4-phenylphenyl)methylsulfonyl]-4-thiophen-2-yl-6-(trifluoromethyl)pyrimidine
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C22H15F3N2O2S2
  1
1
EC50 = 4207 nM
 Bioactivity Info 
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CP0575528
 Compound Info 
1-[(3-ethynylphenyl)methyl]-5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-one
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C20H14F3N3O3S
  1
1
EC50 = 4477 nM
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CP0492747
 Compound Info 
4-(4-methylphenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
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C13H11F3N2O2S
  1
1
EC50 = 6355 nM
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CP0488440
 Compound Info 
4-(2-methylphenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine
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C13H11F3N2O2S
  1
1
EC50 = 6642 nM
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CP0429088
 Compound Info 
methyl 2-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]benzoate
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C14H11F3N2O4S
  1
1
EC50 = 7033 nM
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CP0429086
 Compound Info 
2-methylsulfonyl-4-(3-phenoxyphenyl)-6-(trifluoromethyl)pyrimidine
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C18H13F3N2O3S
  1
1
EC50 = 8756 nM
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CP0381099
 Compound Info 
N,N-dimethyl-3-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]benzamide
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C15H14F3N3O3S
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0410369
 Compound Info 
methyl 4-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]benzoate
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C14H11F3N2O4S
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0410370
 Compound Info 
5-(2-methylsulfonyl-6-thiophen-2-ylpyrimidin-4-yl)pyrrolidin-2-one
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C13H13N3O3S2
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0492748
 Compound Info 
4-methyl-2-methylsulfonyl-6-thiophen-2-ylpyrimidine
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C10H10N2O2S2
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0517799
 Compound Info 
4-[4-[1-[(3,4-dimethoxyphenyl)methyl]-6-oxopyridin-3-yl]-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylbutanamide
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C23H23F3N4O6S
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0517802
 Compound Info 
5-[2-methylsulfonyl-6-(trifluoromethyl)pyrimidin-4-yl]-1H-pyridin-2-one
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C11H8F3N3O3S
  1
1
EC50 > 20000 nM
 Bioactivity Info 
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CP0575897
 Compound Info 
2-methylsulfonyl-4,6-dithiophen-2-ylpyrimidine
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C13H10N2O2S3
  1
1
EC50 > 20000 nM
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CP0575898
 Compound Info 
4-azido-2-methylsulfonyl-6-thiophen-2-ylpyrimidine
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C9H7N5O2S2
  1
1
EC50 > 20000 nM
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