General Information of the Protein
| Protein ID |
PT05838
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| Protein Name |
Prostaglandin E synthase
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| Secondarily Protein Name |
Glutathione peroxidase PTGES
Glutathione transferase PTGES
Microsomal prostaglandin E synthase 1
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| Gene Name |
PTGES
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| Secondarily Gene Name |
Pges
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| Sequence |
MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYYRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Enzyme
>
Isomerase
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| Function |
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway (PubMed:10869354, PubMed:11795891). Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:11795891, PubMed:10869354). Plays a key role in inflammation response, fever and pain (PubMed:12835414, PubMed:14566340). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
| Subcellular Location |
Membrane
Cytoplasm
Perinuclear region
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000023 , BTI-Tn-5B1-4
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000014 , RAW 264.7