General Information of the Protein
Protein ID
PT05403
Protein Name
Prostaglandin E2 receptor EP1 subtype
Secondarily
Protein Name
Prostanoid EP1 receptor
Gene Name
PTGER1
Sequence
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Prostanoid receptor
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.
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Uniprot ID
Primary ID:
P70597

Secondarily ID:
P97537
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000109 , COS-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0519695
 Compound Info 
1-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H17ClN4O2S
  1
1
IC50 = 1.1 nM
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CP0557515
 Compound Info 
6-[(6-methoxy-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H17N3O3
  1
1
IC50 = 6 nM
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CP0510384
 Compound Info 
1-[[6-chloro-2-(diethylamino)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C17H19ClN4O2S
  1
1
IC50 = 6.2 nM
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CP0533843
 Compound Info 
5-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]sulfanyl]furan-2-carboxylic acid
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C17H13ClN2O3S2
  1
1
IC50 = 6.4 nM
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CP0392335
 Compound Info 
6-[(6-chloro-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C20H14ClN3O2
  1
1
IC50 = 8 nM
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CP0411727
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H15ClN4O2
  1
1
IC50 = 9.4 nM
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CP0481525
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-ethenyl-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H20N4O2S
  1
1
IC50 = 9.9 nM
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CP0489170
 Compound Info 
6-[(6-bromo-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C20H14BrN3O2
  1
1
IC50 = 11 nM
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CP0481527
 Compound Info 
1-[[6-chloro-2-[ethyl(methyl)amino]-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C16H17ClN4O2S
  1
1
IC50 = 13 nM
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CP0523257
 Compound Info 
6-[[2-phenyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C21H14F3N3O2
  1
1
IC50 = 16 nM
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CP0566082
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-fluoro-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H17FN4O2S
  1
1
IC50 = 17 nM
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CP0489171
 Compound Info 
6-[(6-methyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H17N3O2
  1
1
IC50 = 19 nM
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CP0560506
 Compound Info 
6-[(6-ethenyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C22H17N3O2
  1
1
IC50 = 21 nM
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CP0484547
 Compound Info 
1-[(5-chloro-2-phenyl-1-benzofuran-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C20H15ClN2O3
  1
1
IC50 = 22 nM
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CP0559181
 Compound Info 
1-[[6-bromo-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H17BrN4O2S
  1
1
IC50 = 22 nM
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CP0475870
 Compound Info 
3-[(6-chloro-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]benzoic acid
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C21H15ClN2O2
  1
1
IC50 = 29 nM
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CP0472686
 Compound Info 
1-[(6-chloro-2-pyrrolidin-1-yl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C17H17ClN4O2S
  1
1
IC50 = 30 nM
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CP0510383
 Compound Info 
1-[[6-chloro-2-(5-methyl-3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H19ClN4O2S
  1
1
IC50 = 30 nM
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CP0517957
 Compound Info 
1-[(6-chloro-2-phenyl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14ClN3O2S
  1
1
IC50 = 31 nM
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CP0460415
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H18N4O2S
  1
1
IC50 = 32 nM
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CP0475118
 Compound Info 
1-[(6-chloro-2-prop-1-en-2-yl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C16H14ClN3O2S
  1
1
IC50 = 33 nM
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CP0571939
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-methoxy-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H20N4O3S
  1
1
IC50 = 37 nM
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CP0460416
 Compound Info 
1-[(6-chloro-2-piperidin-1-yl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C18H19ClN4O2S
  1
1
IC50 = 43 nM
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CP0538602
 Compound Info 
6-[(2-tert-butyl-6-chloropyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H18ClN3O2
  1
1
IC50 = 48 nM
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CP0566081
 Compound Info 
1-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]pyrazole-3-carboxylic acid
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C17H15ClN4O2S
  1
1
IC50 = 51 nM
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CP0534665
 Compound Info 
5-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]furan-2-carboxylic acid
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C18H15ClN2O3S
  1
1
IC50 = 60 nM
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CP0494019
 Compound Info 
5-[(6-methoxy-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]furan-2-carboxylic acid
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C20H16N2O4
  1
1
IC50 = 60 nM
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CP0571941
 Compound Info 
1-[(6-chloro-2-morpholin-4-yl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C17H17ClN4O3S
  1
1
IC50 = 63 nM
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CP0481526
 Compound Info 
1-[[6-chloro-2-(4-methyl-3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H19ClN4O2S
  1
1
IC50 = 64 nM
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CP0519271
 Compound Info 
1-[(6-chloro-2-thiomorpholin-4-yl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C17H17ClN4O2S2
  1
1
IC50 = 66 nM
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CP0458617
 Compound Info 
1-[(5-chloro-2-cyclohexylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H21ClN4O2
  1
1
IC50 = 71 nM
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CP0570333
 Compound Info 
6-[(6-chloro-2-piperidin-1-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C19H19ClN4O2
  1
1
IC50 = 79 nM
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CP0557516
 Compound Info 
6-[(6-methylsulfanyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H17N3O2S
  1
1
IC50 = 87 nM
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CP0479672
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]pyrazole-3-carboxylic acid
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C18H13ClN4O2
  1
1
IC50 = 89 nM
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CP0523133
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-propylpyrazole-3-carboxylic acid
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C21H19ClN4O2
  1
1
IC50 = 97 nM
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CP0458381
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-(trifluoromethoxy)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H17F3N4O3S
  1
1
IC50 = 97 nM
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CP0475117
 Compound Info 
1-[[6-chloro-2-(dimethylamino)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C15H15ClN4O2S
  1
1
IC50 = 100 nM
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CP0446923
 Compound Info 
1-[[5-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H17ClN4O3
  1
1
IC50 = 110 nM
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CP0559183
 Compound Info 
1-[[6-chloro-2-(cyclohexen-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H18ClN3O2S
  1
1
IC50 = 110 nM
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CP0566083
 Compound Info 
1-[[6-chloro-2-(2,5-dihydropyrrol-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C17H15ClN4O2S
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1
IC50 = 110 nM
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CP0569200
 Compound Info 
6-[(6-chloro-2-thiophen-3-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H12ClN3O2S
  1
1
IC50 = 110 nM
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CP0575551
 Compound Info 
2-[(6-chloro-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]-1,3-thiazole-4-carboxylic acid
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C18H12ClN3O2S
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1
IC50 = 110 nM
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CP0479676
 Compound Info 
5-methyl-1-[(2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]pyrazole-3-carboxylic acid
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C19H16N4O2
  1
1
IC50 = 120 nM
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CP0523259
 Compound Info 
6-[[6-chloro-2-(furan-3-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C18H12ClN3O3
  1
1
IC50 = 130 nM
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CP0479674
 Compound Info 
1-[[5-chloro-2-(3-chlorophenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14Cl2N4O2
  1
1
IC50 = 150 nM
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CP0481523
 Compound Info 
5-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]oxy]furan-2-carboxylic acid
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C17H13ClN2O4S
  1
1
IC50 = 150 nM
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CP0475913
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-prop-1-en-2-yl-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C21H22N4O2S
  1
1
IC50 = 160 nM
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CP0472709
 Compound Info 
1-[(5-chloro-2-cyclopropylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C16H15ClN4O2
  1
1
IC50 = 180 nM
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CP0549006
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]pyrrole-3-carboxylic acid
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C19H14ClN3O2
  1
1
IC50 = 190 nM
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CP0569309
 Compound Info 
6-[(6-cyclopropyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C23H19N3O2
  1
1
IC50 = 190 nM
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CP0519374
 Compound Info 
1-[[6-acetyl-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H20N4O3S
  1
1
IC50 = 200 nM
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CP0560508
 Compound Info 
6-[[6-chloro-2-(2-methylpropyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C18H18ClN3O2
  1
1
IC50 = 200 nM
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CP0519381
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-(dimethylamino)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H23N5O2S
  1
1
IC50 = 210 nM
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CP0454782
 Compound Info 
1-[[5-chloro-2-(2-chlorophenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14Cl2N4O2
  1
1
IC50 = 220 nM
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CP0520187
 Compound Info 
1-[[6-cyano-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H17N5O2S
  1
1
IC50 = 230 nM
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CP0475912
 Compound Info 
1-[[6-chloro-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]pyrrole-3-carboxylic acid
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C18H16ClN3O2S
  1
1
IC50 = 240 nM
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CP0560510
 Compound Info 
6-[(6-chloro-2-thiomorpholin-4-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H17ClN4O2S
  1
1
IC50 = 260 nM
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CP0411726
 Compound Info 
1-[[6-chloro-2-[ethyl(propyl)amino]-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H21ClN4O2S
  1
1
IC50 = 270 nM
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CP0519382
 Compound Info 
1-[[2-(azepan-1-yl)-6-chloro-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H21ClN4O2S
  1
1
IC50 = 270 nM
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CP0454781
 Compound Info 
1-[[5-chloro-2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14Cl2N4O2
  1
1
IC50 = 290 nM
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CP0408380
 Compound Info 
6-[(2-phenyl-6-prop-1-en-2-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C23H19N3O2
  1
1
IC50 = 290 nM
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CP0472708
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-ethylpyrazole-3-carboxylic acid
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C20H17ClN4O2
  1
1
IC50 = 300 nM
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CP0549007
 Compound Info 
5-methyl-1-[[2-phenyl-5-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]pyrazole-3-carboxylic acid
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C20H15F3N4O2
  1
1
IC50 = 300 nM
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CP0475116
 Compound Info 
1-[[2-(azetidin-1-yl)-6-chloro-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C16H15ClN4O2S
  1
1
IC50 = 320 nM
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CP0472711
 Compound Info 
1-[(5-ethenyl-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C21H18N4O2
  1
1
IC50 = 360 nM
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CP0411669
 Compound Info 
6-[(6-fluoro-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C20H14FN3O2
  1
1
IC50 = 380 nM
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CP0454779
 Compound Info 
1-[[5-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H17ClN4O3
  1
1
IC50 = 410 nM
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CP0507074
 Compound Info 
1-[(5-chloro-2-cyclopentylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C18H19ClN4O2
  1
1
IC50 = 410 nM
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CP0447004
 Compound Info 
1-[(6-chloro-2-cyclohexyl-1,3-benzothiazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H20ClN3O2S
  1
1
IC50 = 430 nM
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CP0557517
 Compound Info 
6-[(6-cyano-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H14N4O2
  1
1
IC50 = 440 nM
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CP0472712
 Compound Info 
5-methyl-1-[(5-methyl-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]pyrazole-3-carboxylic acid
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C20H18N4O2
  1
1
IC50 = 450 nM
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CP0511748
 Compound Info 
1-[[6-chloro-2-(methylamino)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C14H13ClN4O2S
  1
1
IC50 = 470 nM
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CP0396231
 Compound Info 
6-[[6-chloro-2-(3-chlorophenyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C20H13Cl2N3O2
  1
1
IC50 = 480 nM
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CP0566063
 Compound Info 
1-[(6-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H15ClN4O2
  1
1
IC50 = 540 nM
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CP0523134
 Compound Info 
1-[(5-acetyl-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C21H18N4O3
  1
1
IC50 = 600 nM
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CP0396387
 Compound Info 
6-[[6-chloro-2-(2-chlorophenyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C20H13Cl2N3O2
  1
1
IC50 = 640 nM
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CP0570334
 Compound Info 
6-[(6-chloro-2-morpholin-4-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H17ClN4O3
  1
1
IC50 = 740 nM
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CP0475914
 Compound Info 
1-[(5-chloro-2-phenyl-1,3-benzoxazol-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14ClN3O3
  1
1
IC50 = 750 nM
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CP0570332
 Compound Info 
6-[[6-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C21H16ClN3O3
  1
1
IC50 = 800 nM
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CP0472710
 Compound Info 
1-[[5-chloro-2-(2-methoxyphenyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H17ClN4O3
  1
1
IC50 = 840 nM
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CP0432679
 Compound Info 
1-[(5-cyano-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C20H15N5O2
  1
1
IC50 = 1000 nM
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CP0510395
 Compound Info 
1-[(4-methoxy-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C20H18N4O3
  1
1
IC50 = 1100 nM
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CP0489172
 Compound Info 
6-[[6-chloro-2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C20H13Cl2N3O2
  1
1
IC50 = 1100 nM
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CP0494027
 Compound Info 
6-[(6-acetyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C22H17N3O3
  1
1
IC50 = 1100 nM
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CP0560507
 Compound Info 
6-[(6-chloro-2-thiophen-2-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H12ClN3O2S
  1
1
IC50 = 1100 nM
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CP0417767
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-propan-2-ylpyrazole-3-carboxylic acid
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C21H19ClN4O2
  1
1
IC50 = 1200 nM
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CP0481464
 Compound Info 
6-[[6-chloro-2-(furan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C18H12ClN3O3
  1
1
IC50 = 1200 nM
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CP0481465
 Compound Info 
6-[(6-chloro-2-cyclohexylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C20H20ClN3O2
  1
1
IC50 = 1200 nM
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CP0458614
 Compound Info 
1-[[5-chloro-2-(2-methylpropyl)pyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C17H19ClN4O2
  1
1
IC50 = 1400 nM
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CP0520483
 Compound Info 
6-[[2-(azepan-1-yl)-6-chloropyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C20H21ClN4O2
  1
1
IC50 = 1400 nM
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CP0461855
 Compound Info 
1-[(6-methoxy-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C20H18N4O3
  1
1
IC50 = 1500 nM
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CP0479675
 Compound Info 
1-[[5-[(E)-hex-1-enyl]-2-phenylpyrazolo[1,5-a]pyridin-7-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C25H26N4O2
  1
1
IC50 = 1500 nM
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CP0521213
 Compound Info 
6-[(6-chloro-2-cyclopropylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C17H14ClN3O2
  1
1
IC50 = 1500 nM
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CP0560509
 Compound Info 
6-[(6-chloro-2-pyrrolidin-1-ylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C18H17ClN4O2
  1
1
IC50 = 1800 nM
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CP0479673
 Compound Info 
1-[(2-butyl-5-chloropyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C17H19ClN4O2
  1
1
IC50 = 1900 nM
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CP0446921
 Compound Info 
1-[(5-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-(2-methylpropyl)pyrazole-3-carboxylic acid
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C22H21ClN4O2
  1
1
IC50 = 2000 nM
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CP0417768
 Compound Info 
1-[(2-tert-butyl-5-chloropyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C17H19ClN4O2
  1
1
IC50 = 2100 nM
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CP0523256
 Compound Info 
6-[(2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C20H15N3O2
  1
1
IC50 = 2300 nM
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CP0559180
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-methyl-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H20N4O2S
  1
1
IC50 = 2500 nM
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CP0432691
 Compound Info 
1-[(4-chloro-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H15ClN4O2
  1
1
IC50 = 2600 nM
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CP0571940
 Compound Info 
1-[[6-chloro-2-(1,1-dioxo-1,4-thiazinan-4-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C17H17ClN4O4S2
  1
1
IC50 = 4200 nM
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CP0523260
 Compound Info 
6-[(6-methoxy-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyrazine-2-carboxylic acid
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C20H16N4O3
  1
1
IC50 = 4500 nM
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CP0566084
 Compound Info 
1-[[6-chloro-2-(4-methylpiperazin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H20ClN5O2S
  1
1
IC50 = 4900 nM
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CP0559182
 Compound Info 
1-[[6-chloro-2-(4,5-dimethyl-3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C20H21ClN4O2S
  1
1
IC50 = 5200 nM
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CP0392336
 Compound Info 
6-[(6-methylsulfonyl-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H17N3O4S
  1
1
IC50 = 5400 nM
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CP0569198
 Compound Info 
6-[[6-chloro-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]pyridine-2-carboxylic acid
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C21H16ClN3O3
  1
1
IC50 = 5400 nM
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CP0447003
 Compound Info 
1-[[6-amino-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C18H19N5O2S
  1
1
IC50 = 7800 nM
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CP0534818
 Compound Info 
4-[(3-carboxy-5-methylpyrazol-1-yl)methyl]-2-(3,6-dihydro-2H-pyridin-1-yl)-1,3-benzothiazole-6-carboxylic acid
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C19H18N4O4S
  1
1
IC50 = 7900 nM
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CP0534666
 Compound Info 
1-[(5-chloro-2-phenyl-1,3-benzothiazol-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14ClN3O2S
  1
1
IC50 = 7953 nM
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CP0389262
 Compound Info 
1-[(6-chloro-2-phenyl-1,3-benzoxazol-4-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C19H14ClN3O3
  1
1
IC50 = 8698 nM
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CP0519685
 Compound Info 
1-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-(methylamino)-1,3-benzothiazol-4-yl]methyl]-5-methylpyrazole-3-carboxylic acid
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C19H21N5O2S
  1
1
IC50 = 8800 nM
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CP0408381
 Compound Info 
6-[(5-methoxy-2-phenylpyrazolo[1,5-a]pyridin-3-yl)methyl]pyridine-2-carboxylic acid
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C21H17N3O3
  1
1
IC50 = 9100 nM
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CP0454783
 Compound Info 
1-[(5-methoxy-2-phenylpyrazolo[1,5-a]pyridin-7-yl)methyl]-5-methylpyrazole-3-carboxylic acid
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C20H18N4O3
  1
1
IC50 = 9600 nM
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Cell Line ID: CL000065 , HEK293-EBNA
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02988 Prostaglandin E2 receptor EP1 subtype Mus musculus, Mouse
 Protein Info