General Information of the Protein
Protein ID
PT05383
Protein Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Secondarily
Protein Name
Multisynthase complex auxiliary component p38
Protein JTV-1
Gene Name
AIMP2
Secondarily
Gene Name
JTV1
PRO0992
Sequence
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
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Uniprot ID
Primary ID:
Q13155

Secondarily ID:
F8W950
Q75MR1
Q96CZ5
Q9P1L2
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Ensembl ID
ENSG00000106305
HGNC ID
HGNC:20609
Subcellular Location
Cytoplasm
Cytosol
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000068 , A-549
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0344601
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(4-phenylphenyl)acetamide
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C23H21NO3
  1
1
IC50 = 106.3 nM
 Bioactivity Info 
   TI
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CP0362707
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(4-ethylphenyl)acetamide
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C19H21NO3
  1
1
IC50 = 244 nM
 Bioactivity Info 
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CP0576226
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(5,6-dimethyl-1-benzofuran-3-yl)acetamide
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C21H21NO4
  1
1
IC50 = 280 nM
 Bioactivity Info 
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CP0532984
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(4-hydroxy-2-methylphenyl)acetamide
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C18H19NO4
  1
1
IC50 = 724 nM
 Bioactivity Info 
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CP0571889
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(4-fluorophenyl)acetamide
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C17H16FNO3
  1
1
IC50 = 1210 nM
 Bioactivity Info 
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CP0547079
 Compound Info 
MLS000055798
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C20H19NO4
  1
1
IC50 = 5684 nM
 Bioactivity Info 
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CP0573746
 Compound Info 
3-(3-chloro-4-methylphenyl)-1-[4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]propan-1-one
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C23H25ClN2O4
  1
1
IC50 = 5728 nM
 Bioactivity Info 
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CP0338116
 Compound Info 
3-[5-[(E)-(2,3-dihydro-1,4-benzodioxine-3-carbonylhydrazinylidene)methyl]furan-2-yl]benzoic acid
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C21H16N2O6
  2
1
IC50 = 7379 nM
 Bioactivity Info 
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2
IC50 = 10110 nM
 Bioactivity Info 
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CP0543375
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(6-ethyl-1-benzofuran-3-yl)acetamide
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C21H21NO4
  1
1
IC50 = 8146 nM
 Bioactivity Info 
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CP0547081
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(1H-indol-5-yl)acetamide
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C19H18N2O3
  1
1
IC50 = 8890 nM
 Bioactivity Info 
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CP0543434
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-naphthalen-2-ylacetamide
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C21H19NO3
  1
1
IC50 = 8892 nM
 Bioactivity Info 
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CP0573745
 Compound Info 
6-tert-butyl-N-[(Z)-(2,4-dihydroxyphenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
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C20H22N2O5
  1
1
IC50 = 9725 nM
 Bioactivity Info 
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CP0547078
 Compound Info 
N-[(Z)-(3-bromo-5-ethoxy-4-hydroxyphenyl)methylideneamino]-6-tert-butyl-2,3-dihydro-1,4-benzodioxine-3-carboxamide
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C22H25BrN2O5
  1
1
IC50 = 10610 nM
 Bioactivity Info 
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CP0575444
 Compound Info 
N-[2-[4-(3-chlorophenyl)piperazin-1-yl]-2-oxoethyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
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C21H22ClN3O4
  1
1
IC50 = 11850 nM
 Bioactivity Info 
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CP0532982
 Compound Info 
N-(2-chlorophenyl)-2-[4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]acetamide
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C21H22ClN3O4
  1
1
IC50 = 11920 nM
 Bioactivity Info 
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CP0532983
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-quinolin-6-ylacetamide
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C20H18N2O3
  1
1
IC50 = 13480 nM
 Bioactivity Info 
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CP0543374
 Compound Info 
[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
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C20H21ClN2O3
  1
1
IC50 = 23610 nM
 Bioactivity Info 
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CP0577569
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(6,7-dimethyl-1-benzofuran-3-yl)acetamide
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C21H21NO4
  1
1
IC50 = 29210 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0358675
 Compound Info 
(2S)-3-(1H-indol-3-yl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-[(4-methylphenyl)sulfonylamino]propanamide
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C28H26N4O4S2
  1
1 Kd = 3070 nM
CP0470469
 Compound Info 
4-(4-chlorophenyl)-N-[3-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]pyrimidin-2-amine
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C23H26ClN5O
  1
1 Kd = 3850 nM
CP0227790
 Compound Info 
4-(4-chlorophenyl)-6-(3-methoxypiperidin-1-yl)-N-[3-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]pyrimidin-2-amine
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C29H37ClN6O2
  1
1 Kd = 14340 nM
Clinical Information about the Protein
Target 1 ( AIMP multisynthetase complex protein 2 (AIMP2) )
Target Type Literature-reported Target