General Information of the Compound
Compound ID
CP0543374
Compound Name
[4-[(3-chlorophenyl)methyl]piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
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Structure
Formula
C20H21ClN2O3
Molecular Weight
372.852
Canonical SMILES
Clc1cccc(CN2CCN(CC2)C(=O)C2COc3ccccc3O2)c1
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InChI
InChI=1S/C20H21ClN2O3/c21-16-5-3-4-15(12-16)13-22-8-10-23(11-9-22)20(24)19-14-25-17-6-1-2-7-18(17)26-19/h1-7,12,19H,8-11,13-14H2
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InChIKey
WWZCAMSUEMBIPA-UHFFFAOYSA-N
Physicochemical Property
logP
2.8242
Rotatable Bonds
3
Heavy Atom Count
26
Polar Areas
42.01
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42914196
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05383, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 23610 nM
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