General Information of the Protein
Protein ID
PT05120
Protein Name
Transmembrane domain-containing protein TMIGD3
Gene Name
TMIGD3
Secondarily
Gene Name
UNQ1931/PRO4406
Sequence
MEGSPAGPIEQKEARWESSWEEQPDWTLGCLSPESQFRIPGLPGCILSFQLKVCFLPVMWLFILLSLALISDAMVMDEKVKRSFVLDTASAICNYNAHYKNHPKYWCRGYFRDYCNIIAFSPNSTNHVALRDTGNQLIVTMSCLTKEDTGWYWCGIQRDFARDDMDFTELIVTDDKGTLANDFWSGKDLSGNKTRSCKAPKVVRKADRSRTSILIICILITGLGIISVISHLTKRRRSQRNRRVGNTLKPFSRVLTPKEMAPTEQM
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).
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Uniprot ID
Primary ID:
P0DMS9

Secondarily ID:
A2A3P4
P33765
Q5QNY7
Q6P2N6
Q6UWU0
Q9BYZ1
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HGNC ID
HGNC:51375
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0377126
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-methyl-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C22H21N5O3
  2
1
EC50 = 3.16 nM
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2
Ki = 6.01 nM
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CP0047143
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H18ClN5O3S
  2
1
EC50 = 12.5 nM
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2
Ki = 42.2 nM
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CP0377124
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C19H16ClN5O3S
  2
1
EC50 = 26.9 nM
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2
Ki = 60 nM
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CP0378901
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methoxybenzamide
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C26H20N4O2
  2
1
IC50 = 73 nM
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2
Ki = 25 nM
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CP0457758
 Compound Info 
N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide
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C19H14N4O
  2
1
IC50 = 163 nM
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2
Ki = 52 nM
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CP0457757
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)pyridine-3-carboxamide
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C24H17N5O
  2
1
IC50 = 172 nM
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2
Ki = 54 nM
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CP0378887
 Compound Info 
N-benzoyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide
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C26H18N4O2
  2
1
IC50 = 187 nM
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2
Ki = 64 nM
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CP0378889
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)benzamide
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C25H18N4O
  2
1
IC50 = 235 nM
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2
Ki = 82 nM
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CP0429756
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-azido-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C14H17N9O3
  1
1
Ki = 0.54 nM
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CP0429754
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(5-bromothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H20BrN9O3S
  1
1
Ki = 0.58 nM
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CP0429747
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-azido-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C15H19N9O3
  1
1
Ki = 0.69 nM
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CP0380111
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H20ClN9O3S
  1
1
Ki = 0.73 nM
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CP0406219
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-azido-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C17H21N9O3
  1
1
Ki = 0.85 nM
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CP0448162
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-azido-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H23N9O3
  1
1
Ki = 0.85 nM
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CP0403428
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-4-[2-iodo-6-(2-phenylethylamino)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H23IN6O3
  1
1
Ki = 0.91 nM
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CP0448163
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(2-chlorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C22H22ClN9O3
  1
1
Ki = 0.95 nM
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CP0403426
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-phenyltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C22H23N9O3
  1
1
Ki = 0.96 nM
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CP0408337
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(furan-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H21N9O4
  1
1
Ki = 0.96 nM
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CP0406218
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(3,4-difluorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C22H21F2N9O3
  1
1
Ki = 1.06 nM
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CP0429757
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-azido-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H20ClN9O3
  1
1
Ki = 1.08 nM
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CP0406220
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H22ClN9O3S
  1
1
Ki = 1.22 nM
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CP0429755
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-(ethylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C15H19IN6O3
  1
1
Ki = 1.22 nM
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CP0467517
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(1-benzofuran-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C24H23N9O4
  1
1
Ki = 1.25 nM
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CP0467515
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-(cyclobutylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C17H21IN6O3
  1
1
Ki = 1.53 nM
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CP0108871
 Compound Info 
(1S,2R,3S,4R,5S)-4-[5-[2-(5-chlorothiophen-2-yl)ethynyl]-7-(ethylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C22H22ClN5O3S
  1
1
Ki = 1.69 nM
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CP0406162
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyridin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C21H22N10O3
  1
1
Ki = 1.84 nM
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CP0467516
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-[4-(1-methylpyrazol-4-yl)triazol-1-yl]purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C20H23N11O3
  1
1
Ki = 2.16 nM
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CP0406163
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrazin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C20H21N11O3
  1
1
Ki = 2.21 nM
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CP0448165
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrimidin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C20H21N11O3
  1
1
Ki = 3.48 nM
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CP0461967
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C27H26ClN9O3S
  1
1
Ki = 6.66 nM
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CP0406164
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C23H24ClN9O3S
  1
1
Ki = 7.05 nM
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CP0448164
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C26H23Cl2N9O3S
  1
1
Ki = 9.02 nM
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CP0039348
 Compound Info 
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
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C12H16N6O4
  1
1
Ki = 16 nM
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CP0115573
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H21ClN6O3S
  1
1
Ki = 23.5 nM
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CP0853605
 Compound Info 
N2-benzyl-8-(furan-2-yl)-9-propyl-9H-purine-2,6-diamine
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C19H20N6O
  1
1
Ki = 29 nM
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CP0155461
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H25ClN6O3
  1
1
Ki = 34 nM
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CP0408108
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)-4-fluorobenzamide
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C25H17FN4O
  1
1
Ki = 38 nM
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CP0868036
 Compound Info 
8-(Furan-2-yl)-N2-phenethyl-9-propyl-9H-purine-2,6-diamine
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C20H22N6O
  1
1
Ki = 56 nM
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CP0539956
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)furan-2-carboxamide
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C23H16N4O2
  1
1
Ki = 67 nM
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CP0377122
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-4-[6-[(Z)-2-hydroxy-2-phenylethenyl]-2-(2-phenylethynyl)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C29H25N5O4
  1
1
Ki = 78.5 nM
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CP0452635
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(4-tert-butylphenyl)ethynyl]-6-[(Z)-2-(4-tert-butylphenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C37H41N5O4
  1
1
Ki = 94.3 nM
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CP0390613
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-difluorophenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C22H19F2N5O3
  1
1
Ki = 98.5 nM
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CP0155496
 Compound Info 
N-[(3-chlorophenyl)methyl]-2-[2-(3,4-difluorophenyl)ethynyl]-7H-purin-6-amine
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C20H12ClF2N5
  1
1
Ki = 120 nM
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CP0378900
 Compound Info 
N-[2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]benzamide
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C20H16N4O2
  1
1
Ki = 121 nM
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CP0469681
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-difluorophenyl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H17F2N5O3
  1
1
Ki = 124 nM
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CP0408109
 Compound Info 
4-chloro-N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)benzamide
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C25H17ClN4O
  1
1
Ki = 156 nM
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CP0155247
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C18H24ClN5O3
  1
1
Ki = 160 nM
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CP0378888
 Compound Info 
4-methoxy-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamide
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C20H16N4O2
  1
1
Ki = 162 nM
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CP0067834
 Compound Info 
2-chloro-N-[(3-chlorophenyl)methyl]-7H-purin-6-amine
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C12H9Cl2N5
  1
1
Ki = 165 nM
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CP0429542
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)thiophene-2-carboxamide
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C23H16N4OS
  1
1
Ki = 185 nM
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CP0457756
 Compound Info 
N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methylbenzamide
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C26H20N4O
  1
1
Ki = 223 nM
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CP0139865
 Compound Info 
ethyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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C21H26ClN5O4
  1
1
Ki = 236 nM
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CP0539976
 Compound Info 
2,2-diphenyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)acetamide
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C26H20N4O
  1
1
Ki = 245 nM
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CP0860138
 Compound Info 
8-(Furan-2-yl)-N2-(3-phenylpropyl)-9-propyl-9H-purine-2,6-diamine
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C21H24N6O
  1
1
Ki = 266 nM
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CP0377123
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(4-tert-butylphenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C26H29N5O3
  1
1
Ki = 305 nM
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CP0513732
 Compound Info 
N-[2-(4-methoxyphenyl)-6-phenylimidazo[1,2-a]pyrazin-8-yl]benzamide
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C26H20N4O2
  1
1
Ki = 312 nM
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CP0509137
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-methyl-2-(2-pyrazin-2-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C20H19N7O3
  1
1
Ki = 343 nM
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CP0868038
 Compound Info 
N-benzyl-8-(furan-2-yl)-9-propyl-9H-purin-6-amine
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C19H19N5O
  1
1
Ki = 402 nM
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CP0169100
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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C18H22ClN5O2
  1
1
Ki = 470 nM
 Bioactivity Info 
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CP0115572
 Compound Info 
propyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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C22H28ClN5O4
  1
1
Ki = 499 nM
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CP0469679
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(2-chlorophenyl)ethynyl]-6-[(Z)-2-(2-chlorophenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C29H23Cl2N5O4
  1
1
Ki = 515 nM
 Bioactivity Info 
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CP0394338
 Compound Info 
2-phenyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)acetamide
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C20H16N4O
  1
1
Ki = 524 nM
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CP0474139
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[2-(methylamino)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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C14H18N6O3
  1
1
Ki = 604 nM
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CP0871535
 Compound Info 
N2-Benzyl-8-bromo-9-propyl-9H-purine-2,6-diamine
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C15H17BrN6
  1
1
Ki = 650 nM
 Bioactivity Info 
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CP0382847
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-methoxypurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C20H18ClN5O4S
  1
1
Ki = 684 nM
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CP0799799
 Compound Info 
3-(4-Bromothiophen-2-yl)-8-hydroxycoumarin
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C13H7BrO3S
  1
1
Ki = 746 nM
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CP0046685
 Compound Info 
methyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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C20H24ClN5O4
  1
1
Ki = 766 nM
 Bioactivity Info 
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CP0405999
 Compound Info 
8-(furan-2-yl)-9-propylpurin-6-amine
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C12H13N5O
  1
1
Ki = 790 nM
 Bioactivity Info 
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CP0853599
 Compound Info 
8-(Furan-2-yl)-N-phenethyl-9-propyl-9H-purin-6-amine
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C20H21N5O
  1
1
Ki = 811 nM
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CP0871533
 Compound Info 
8-(Furan-2-yl)-N-(3-phenylpropyl)-9-propyl-9H-purin-6-amine
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C21H23N5O
  1
1
Ki = 959 nM
 Bioactivity Info 
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CP0203245
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acid
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C14H16ClN5O4
  1
1
Ki = 1080 nM
 Bioactivity Info 
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CP0377125
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-[(Z)-2-hydroxy-2-phenylethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C21H20ClN5O4
  1
1
Ki = 1140 nM
 Bioactivity Info 
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CP0850612
 Compound Info 
8-Bromo-N2-phenethyl-9-propyl-9H-purine-2,6-diamine
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C16H19BrN6
  1
1
Ki = 1160 nM
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CP0385204
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(pentan-3-ylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C17H24ClN5O3
  1
1
Ki = 1200 nM
 Bioactivity Info 
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CP0215226
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1R)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C19H26ClN5O3
  1
1
Ki = 1240 nM
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CP0799798
 Compound Info 
8-Hydroxy-3-(thiophen-2-yl)coumarin
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C13H8O3S
  1
1
Ki = 1430 nM
 Bioactivity Info 
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CP0566738
 Compound Info 
(1S,2R,3S,4R,5S)-2,3-dihydroxy-4-[2-[(Z)-2-hydroxy-2-pyrazin-2-ylethenyl]purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C19H19N7O4
  1
1
Ki = 1480 nM
 Bioactivity Info 
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CP0386313
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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C15H19ClN6O3
  1
1
Ki = 1480 nM
 Bioactivity Info 
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CP0067796
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C19H24ClN5O3
  1
1
Ki = 1600 nM
 Bioactivity Info 
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CP0203246
 Compound Info 
(1S,2R,3S,4R,5S)-N-(2-acetamidoethyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide
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C23H30ClN7O4
  1
1
Ki = 1650 nM
 Bioactivity Info 
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CP0385205
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C18H24ClN5O3
  1
1
Ki = 1810 nM
 Bioactivity Info 
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CP0756037
 Compound Info 
8-Acetoxy-3-(thiophen-3-yl)coumarin
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C15H10O4S
  1
1
Ki = 1820 nM
 Bioactivity Info 
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CP0853604
 Compound Info 
8-Bromo-N2-(3-phenylpropyl)-9-propyl-9H-purine-2,6-diamine
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C17H21BrN6
  1
1
Ki = 1950 nM
 Bioactivity Info 
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CP0386314
 Compound Info 
(1S,2R,3S,4R,5S)-N-(3-acetamidopropyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide
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C24H32ClN7O4
  1
1
Ki = 1970 nM
 Bioactivity Info 
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CP0215227
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dimethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C14H18ClN5O3
  1
1
Ki = 2470 nM
 Bioactivity Info 
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CP0911667
 Compound Info 
8-Bromo-N-phenethyl-9-propyl-9H-purin-6-amine
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C16H18BrN5
  1
1
Ki = 2520 nM
 Bioactivity Info 
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CP0758153
 Compound Info 
8-Acetoxy-3-(thiophen-2-yl)coumarin
   Show/Hide
C15H10O4S
  1
1
Ki = 2580 nM
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CP0730942
 Compound Info 
8-Hydroxy-3-(thiophen-3-yl)coumarin
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C13H8O3S
  1
1
Ki = 2870 nM
 Bioactivity Info 
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CP0067797
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(S)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C20H26ClN5O3
  1
1
Ki = 3240 nM
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CP0657339
 Compound Info 
3-(4-bromothiophen-2-yl)-7,8-dihydroxy-2H-chromen-2-one
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C13H7BrO4S
  1
1
Ki = 3400 nM
 Bioactivity Info 
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CP0385206
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(1S)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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C19H26ClN5O3
  1
1
Ki = 3450 nM
 Bioactivity Info 
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CP0307298
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[[(R)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C20H26ClN5O3
  1
1
Ki = 3470 nM
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CP0730941
 Compound Info 
2-oxo-3-(thiophen-3-yl)-2H-chromene-7,8-diyl diacetate
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C17H12O6S
  1
1
Ki = 3600 nM
 Bioactivity Info 
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CP0756382
 Compound Info 
8-Acetoxy-3-(4-bromothiophen-2-yl)coumarin
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C15H9BrO4S
  1
1
Ki = 4080 nM
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CP0904720
 Compound Info 
7,8-dihydroxy-3-(thiophen-2-yl)-2H-chromen-2-one
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C13H8O4S
  1
1
Ki = 4830 nM
 Bioactivity Info 
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CP0372968
 Compound Info 
(1'R,2'R,3'S,4'R,5'S)-4'-[2-Chloro-6-(3-chlorobenzylamino)-purine]-2',3'-O-dihydroxybicyclo-[3.1.0]hexane
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C18H17Cl2N5O2
  1
1
Ki = 4900 nM
 Bioactivity Info 
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CP0922130
 Compound Info 
7,8-dihydroxy-3-(thiophen-3-yl)-2H-chromen-2-one
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C13H8O4S
  1
1
Ki = 5310 nM
 Bioactivity Info 
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CP0902366
 Compound Info 
N2-benzyl-9-propyl-9H-purine-2,6-diamine
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C15H18N6
  1
1
Ki = 5840 nM
 Bioactivity Info 
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CP0850599
 Compound Info 
N2-phenethyl-9-propyl-9H-purine-2,6-diamine
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C16H20N6
  1
1
Ki = 5880 nM
 Bioactivity Info 
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CP0237413
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acid
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C19H22ClN5O4
  1
1
Ki = 5980 nM
 Bioactivity Info 
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CP0868035
 Compound Info 
N-benzyl-8-bromo-9-propyl-9H-purin-6-amine
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C15H16BrN5
  1
1
Ki = 11100 nM
 Bioactivity Info 
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CP0851034
 Compound Info 
8-Bromo-N-(3-phenylpropyl)-9-propyl-9H-purin-6-amine
   Show/Hide
C17H20BrN5
  1
1
Ki = 12200 nM
 Bioactivity Info 
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CP0853606
 Compound Info 
N2-(3-phenylpropyl)-9-propyl-9H-purine-2,6-diamine
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C17H22N6
  1
1
Ki = 12600 nM
 Bioactivity Info 
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CP0850611
 Compound Info 
N-phenethyl-9-propyl-9H-purin-6-amine
   Show/Hide
C16H19N5
  1
1
Ki = 16900 nM
 Bioactivity Info 
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CP0801197
 Compound Info 
7,8-Diacetoxy-3-(thiophen-2-yl)coumarin
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C17H12O6S
  1
1
Ki = 22500 nM
 Bioactivity Info 
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CP0902367
 Compound Info 
N-benzyl-9-propyl-9H-purin-6-amine
   Show/Hide
C15H17N5
  1
1
Ki = 29100 nM
 Bioactivity Info 
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CP0946757
 Compound Info 
N-(3-phenylpropyl)-9-propyl-9H-purin-6-amine
   Show/Hide
C17H21N5
  1
1
Ki = 30000 nM
 Bioactivity Info 
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CP0042654
 Compound Info 
1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
   Show/Hide
C7H8N4O2
  1
1
Ki = 86400 nM
 Bioactivity Info 
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CP0385412
 Compound Info 
9-Propyl-9H-adenine
   Show/Hide
C8H11N5
  1
1
Ki > 100000 nM
 Bioactivity Info 
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CP0385413
 Compound Info 
8-Bromo-9-propyl-9H-adenine
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C8H10BrN5
  1
1
Ki > 100000 nM
 Bioactivity Info 
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CP0890934
 Compound Info 
3-(4-bromothiophen-2-yl)-2-oxo-2H-chromene-7,8-diyl diacetate
   Show/Hide
C17H11BrO6S
  1
1
Ki > 100000 nM
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Cell Line ID: CL001015 , CHO CRE-SPAP
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info