General Information of the Protein
Protein ID
PT04823
Protein Name
Adenosine receptor A2b
Gene Name
ADORA2B
Sequence
MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRMELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGQAGAQSTLSLGL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Adenosine receptor
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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Uniprot ID
Primary ID:
Q60614

Secondarily ID:
Q8BXI2
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0422261
 Compound Info 
4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine
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C17H12N6O
  1
1
IC50 = 349 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415983
 Compound Info 
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
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C18H22F3N3O4S
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0099922
 Compound Info 
N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
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C18H14FN5O
  1
1
IC50 = 512 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377686
 Compound Info 
8-(4-(4-(4-Chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propyl-3,7-dihydropurine-2,6-dione
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C24H25ClN6O4S
  1
1
Kd = 0.351 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420803
 Compound Info 
8-[4-[4-(4-bromophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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C24H25BrN6O4S
  1
1
Ki = 0.131 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424466
 Compound Info 
8-[4-[4-[(3-bromophenyl)methyl]piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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C25H27BrN6O4S
  1
1
Ki = 0.901 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420820
 Compound Info 
8-[4-[4-(3-fluorophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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C24H25FN6O4S
  1
1
Ki = 0.926 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391881
 Compound Info 
N-[2-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)ethyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
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C31H34BF2N7O4
  1
1
Ki = 1.32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069838
 Compound Info 
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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C26H26N6O4
  1
1
Ki = 3.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420800
 Compound Info 
8-[4-[4-(4-chlorophenyl)piperazin-1-yl]sulfonylphenyl]-3-methyl-1-propyl-7H-purine-2,6-dione
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C25H27ClN6O4S
  1
1
Ki = 8.34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065233
 Compound Info 
4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
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C14H14N4O5S
  1
1
Ki = 1940 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0043620
 Compound Info 
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
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C8H10N4O2
  1
1
Ki = 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0069838
 Compound Info 
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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C26H26N6O4
  1
1 Ki = 3.39 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02131 Adenosine receptor A2b Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01278 Adenosine receptor A2b Homo sapiens, Human
 Protein Info