General Information of the Protein
Protein ID
PT02131
Protein Name
Adenosine receptor A2b
Gene Name
ADORA2B
Sequence
MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Adenosine receptor
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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Uniprot ID
P29276
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0415983
 Compound Info 
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
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C18H22F3N3O4S
  1
1
IC50 = 280 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0391881
 Compound Info 
N-[2-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)ethyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
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C31H34BF2N7O4
  1
1
Ki = 0.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398710
 Compound Info 
1,3-dibutyl-9-[2-[4-[2-(diethylamino)ethoxy]phenyl]ethyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C30H46N6O3
  1
1
Ki = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065233
 Compound Info 
4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
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C14H14N4O5S
  1
1
Ki = 3140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0043620
 Compound Info 
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
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C8H10N4O2
  1
1
Ki = 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398703
 Compound Info 
1,3-dipropyl-9-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C26H36N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398705
 Compound Info 
1,3-dibutyl-9-[4-[2-(diethylamino)ethoxy]phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C28H42N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398706
 Compound Info 
1,3-dibutyl-9-[4-(2-piperidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C29H42N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0408997
 Compound Info 
1,3-diethyl-9-[2-(4-hydroxyphenyl)ethyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C20H25N5O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420550
 Compound Info 
1,3-dibutyl-9-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C28H40N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0450331
 Compound Info 
9-[2-[4-[2-(diethylamino)ethoxy]phenyl]ethyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C24H34N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0473554
 Compound Info 
1,3-dibutyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C26H38N6O3
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0069838
 Compound Info 
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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C26H26N6O4
  1
1 Ki = 12.8 nM
CP0042654
 Compound Info 
1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
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C7H8N4O2
  1
1 Ki = 15100 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT04823 Adenosine receptor A2b Mus musculus, Mouse
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01278 Adenosine receptor A2b Homo sapiens, Human
 Protein Info