General Information of the Protein
Protein ID
PT04759
Protein Name
Prostaglandin F2-alpha receptor
Secondarily
Protein Name
Prostanoid FP receptor
Gene Name
PTGFR
Sequence
MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Prostanoid receptor
Function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).
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Uniprot ID
P43117
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0431698
 Compound Info 
2-[1-[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]-5-fluoro-2-methylindol-3-yl]acetic acid
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C28H24ClFN2O5
  1
1
Ki = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388465
 Compound Info 
2-[1-[4-[[(2R)-1-ethyl-2,3-dihydroindol-2-yl]methoxy]-2-methylbenzoyl]-2-methylindol-3-yl]acetic acid
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C30H30N2O4
  1
1
Ki = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376006
 Compound Info 
2-[2,5-dimethyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid
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C29H28N2O5
  1
1
Ki = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378355
 Compound Info 
2-[5-fluoro-2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid
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C28H25FN2O5
  1
1
Ki = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388261
 Compound Info 
2-[2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid
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C28H26N2O5
  1
1
Ki = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428289
 Compound Info 
2-[5-chloro-2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid
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C28H25ClN2O5
  1
1
Ki = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425413
 Compound Info 
2-[2-methyl-1-[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-3-yl]acetic acid
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C29H28N2O5
  1
1
Ki = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400679
 Compound Info 
2-[2-methyl-1-[4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]indol-4-yl]acetic acid
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C28H26N2O5
  1
1
Ki = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377711
 Compound Info 
2-[4-methyl-3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid
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C27H28N2O5
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380709
 Compound Info 
2-[4-chloro-3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid
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C25H22Cl2N2O5
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387733
 Compound Info 
2-[3-methyl-5-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid
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C27H28N2O5
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390164
 Compound Info 
2-[3-[[2-chloro-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]-4-fluorophenyl]acetic acid
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C25H22ClFN2O5
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494477
 Compound Info 
2-[3-[[2-methyl-4-[[(2S)-4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl]methoxy]benzoyl]amino]phenyl]acetic acid
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C26H26N2O5
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0272414
 Compound Info 
US11149018, Example 34
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C26H27BrClN3O3
  1
1 IC50 ~ 5 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT07686 Prostaglandin F2-alpha receptor Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01823 Prostaglandin F2-alpha receptor Homo sapiens, Human
 Protein Info