Protein Information

General Information of the Protein

Protein ID	PT04668
Protein Name	Thyrotropin-releasing hormone receptor
Secondarily Protein Name	Thyroliberin receptor
Gene Name	TRHR
Sequence	MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN Show/Hide
Organism	Mus musculus, Mouse
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Neuropeptide receptor
Function	Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Show/Hide
Uniprot ID	P21761
Ensembl ID	ENSG00000174417
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0067202 Compound Info	1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide Show/Hide	C16H22N6O4	4
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 2.6 nM Bioactivity Info	TI LI LO TS
4	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0403074 Compound Info	(2S)-N-[(2S)-3-(2-bromo-1-methylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C17H23BrN6O4	3
1	EC50 = 3.4 nM Bioactivity Info	TI LI LO TS
2	EC50 = 28 nM Bioactivity Info	TI LI LO TS
3	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0385686 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-ethyl-2-iodoimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C18H25IN6O4	3
1	EC50 = 4.9 nM Bioactivity Info	TI LI LO TS
2	EC50 = 13 nM Bioactivity Info	TI LI LO TS
3	IC50 = 1180 nM Bioactivity Info	TI LI LO TS
CP0404602 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2-iodo-1-methylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C17H23IN6O4	3
1	EC50 = 5.9 nM Bioactivity Info	TI LI LO TS
2	EC50 = 31 nM Bioactivity Info	TI LI LO TS
3	IC50 = 324 nM Bioactivity Info	TI LI LO TS
CP0403073 Compound Info	(2S)-N-[(2S)-3-(2-bromo-1-ethylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C18H25BrN6O4	3
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1830 nM Bioactivity Info	TI LI LO TS
3	IC50 = 18600 nM Bioactivity Info	TI LI LO TS
CP0404607 Compound Info	(2S)-N-[(2S)-3-(1-benzyl-2,5-diiodoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C23H26I2N6O4	3
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
2	EC50 = 53 nM Bioactivity Info	TI LI LO TS
3	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0848540 Compound Info	N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-1-oxo-3-(2-propyl-1H-imidazol-4-yl)propan-2-yl)-5-methylpyrazine-2-carboxamide Show/Hide	C20H27N7O3	2
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0455656 Compound Info	(2S)-N-[(2S)-3-(1-benzyl-2-iodoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C23H27IN6O4	3
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
2	EC50 = 339 nM Bioactivity Info	TI LI LO TS
3	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0385924 Compound Info	(2S)-N-[(2S)-3-(2-bromo-1-propylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C19H27BrN6O4	2
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0382215 Compound Info	N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,4-dibromo-1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-methylpyrazine-2-carboxamide Show/Hide	C17H19Br2N7O3	2
1	EC50 = 77 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0867216 Compound Info	N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-1-oxo-3-(2-propyl-1H-imidazol-4-yl)propan-2-yl)pyrazine-2-carboxamide Show/Hide	C19H25N7O3	2
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0385687 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-ethyl-2,5-diiodoimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C18H24I2N6O4	3
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
2	EC50 = 249 nM Bioactivity Info	TI LI LO TS
3	IC50 = 29340 nM Bioactivity Info	TI LI LO TS
CP0404608 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,5-diiodo-1-methylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C17H22I2N6O4	3
1	EC50 = 272 nM Bioactivity Info	TI LI LO TS
2	EC50 = 36350 nM Bioactivity Info	TI LI LO TS
3	IC50 = 48030 nM Bioactivity Info	TI LI LO TS
CP0515385 Compound Info	3-amino-N-[(2S)-3-(4-bromo-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C16H19BrN8O3	2
1	EC50 = 287 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0404605 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2-chloro-1-methylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C17H23ClN6O4	3
1	EC50 = 320 nM Bioactivity Info	TI LI LO TS
2	EC50 = 790 nM Bioactivity Info	TI LI LO TS
3	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0380508 Compound Info	N-[(2S)-3-(5-bromo-1-methylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C17H20BrN7O3	2
1	EC50 = 340 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0380484 Compound Info	N-[(2S)-3-(4-bromo-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-methylpyrazine-2-carboxamide Show/Hide	C17H20BrN7O3	2
1	EC50 = 498 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0380507 Compound Info	N-[(2S)-3-(1-benzyl-2,5-diiodoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-methylpyrazine-2-carboxamide Show/Hide	C24H25I2N7O3	2
1	EC50 = 740 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0448149 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,5-diiodo-1-propylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C19H26I2N6O4	3
1	EC50 = 780 nM Bioactivity Info	TI LI LO TS
2	EC50 = 2400 nM Bioactivity Info	TI LI LO TS
3	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0380486 Compound Info	(2R)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propyl-1H-imidazol-5-yl)propan-2-yl]piperidine-2-carboxamide Show/Hide	C20H32N6O3	2
1	EC50 = 940 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0429046 Compound Info	N-[(2S)-3-(1-benzyl-2,5-diiodoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C23H23I2N7O3	2
1	EC50 = 980 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0431472 Compound Info	(2R)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propan-2-yl-1H-imidazol-5-yl)propan-2-yl]piperidine-2-carboxamide Show/Hide	C20H32N6O3	2
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0867217 Compound Info	3-amino-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(2,5-dibromo-1H-imidazol-4-yl)-1-oxopropan-2-yl)pyrazine-2-carboxamide Show/Hide	C16H18Br2N8O3	2
1	EC50 = 1410 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0380485 Compound Info	3-amino-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propyl-1H-imidazol-5-yl)propan-2-yl]pyrazine-2-carboxamide Show/Hide	C19H26N8O3	2
1	EC50 = 1560 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0045937 Compound Info	N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,4-dibromo-1H-imidazol-5-yl)-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C16H17Br2N7O3	2
1	EC50 = 2540 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0431506 Compound Info	N-[(2S)-3-(4-bromo-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C16H18BrN7O3	2
1	EC50 = 3980 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0392458 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,4-dichloro-1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C16H20Cl2N6O4	3
1	EC50 = 5970 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12900 nM Bioactivity Info	TI LI LO TS
3	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0411527 Compound Info	N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-ethyl-2,5-diiodoimidazol-4-yl)-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C18H21I2N7O3	2
1	EC50 = 7210 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0849355 Compound Info	N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(2,5-diiodo-1H-imidazol-4-yl)-1-oxopropan-2-yl)pyrazine-2-carboxamide Show/Hide	C16H17I2N7O3	2
1	EC50 = 11280 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0385688 Compound Info	(2S)-N-[(2S)-3-(1-benzyl-2-chloroimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C23H27ClN6O4	3
1	EC50 = 15720 nM Bioactivity Info	TI LI LO TS
2	EC50 = 26270 nM Bioactivity Info	TI LI LO TS
3	IC50 = 20400 nM Bioactivity Info	TI LI LO TS
CP0515386 Compound Info	N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(4-chloro-1H-imidazol-5-yl)-1-oxopropan-2-yl]pyrazine-2-carboxamide Show/Hide	C16H18ClN7O3	2
1	EC50 = 19350 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0392457 Compound Info	(2S)-N-[(2S)-3-(1-benzyl-2-bromoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C23H27BrN6O4	2
1	EC50 > 50000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0392456 Compound Info	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(2,4-diiodo-1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Show/Hide	C16H20I2N6O4	2
1	EC50 > 50000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 50000 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT04767	Thyrotropin-releasing hormone receptor	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han