Brief Information of the Compound and Protein
Compound Name
(2S)-N-[(2S)-3-(1-benzyl-2-iodoimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
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PubChem ID
CID: 127032876
Canonical SMILES
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1
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Compound Formula C23H27IN6O4
Compound Structure
Protein Name
Thyrotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
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Neuropeptide receptor
Uniprot ID
P21761
Gene Name
TRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
2
EC50 = 339 nM
   TI
   LI
   LO
   TS
3
IC50 > 50000 nM
   TI
   LI
   LO
   TS