General Information of the Protein
Protein ID
PT04583
Protein Name
Prokineticin receptor 1
Secondarily
Protein Name
G-protein coupled receptor 73
G-protein coupled receptor ZAQ
GPR73a
Gene Name
PROKR1
Secondarily
Gene Name
GPR73
PKR1
Sequence
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Peptide growth factor receptor (family A GPCR)
>
Prokineticin receptor
Function
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
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Uniprot ID
Primary ID:
Q8TCW9

Secondarily ID:
A5JUU2
Q53QT9
Q8NFJ7
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Ensembl ID
ENSG00000169618
HGNC ID
HGNC:4524
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0457451
 Compound Info 
1-(2-(5-(4-chlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H24ClN7O3
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
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CP0469781
 Compound Info 
1-(2-(1,5-bis(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
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CP0527532
 Compound Info 
1-(2-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H23Cl2N7O3
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
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CP0481722
 Compound Info 
1-(2-(1-(4-hydroxybenzyl)-5-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O4
  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
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CP0418705
 Compound Info 
1-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H24FN7O3
  1
1
IC50 = 33 nM
 Bioactivity Info 
   TI
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CP0398342
 Compound Info 
1-(2-(5-(3,4-dichlorobenzyl)-1-(4-(difluoromethoxy)benzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H21Cl2F2N7O3
  1
1
IC50 = 47 nM
 Bioactivity Info 
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CP0521460
 Compound Info 
1-(2-(5-(4-methoxybenzyl)-1-((6-methoxypyridin-3-yl)methyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H26N8O4
  1
1
IC50 = 51 nM
 Bioactivity Info 
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CP0473857
 Compound Info 
1-(2-(5-(4-cyanobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H24N8O3
  1
1
IC50 = 318 nM
 Bioactivity Info 
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CP0398349
 Compound Info 
1-(2-(5-benzyl-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O3
  1
1
IC50 = 336 nM
 Bioactivity Info 
   TI
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   LO
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CP0528579
 Compound Info 
1-(2-(1-(4-methoxybenzyl)-5-(4-methoxyphenethyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C23H29N7O4
  1
1
IC50 = 461 nM
 Bioactivity Info 
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CP0439772
 Compound Info 
1-(2-(5-(3,4-dichlorobenzyl)-4,6-dioxo-1-(4-propoxybenzyl)-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C23H27Cl2N7O3
  1
1
IC50 = 515 nM
 Bioactivity Info 
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CP0439770
 Compound Info 
1-(2-(5-(4-hydroxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O4
  1
1
IC50 = 1160 nM
 Bioactivity Info 
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CP0472246
 Compound Info 
1-(3-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)propyl)guanidine
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C22H25Cl2N7O3
  1
1
IC50 = 1210 nM
 Bioactivity Info 
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CP0481723
 Compound Info 
1-(2-(5-(4-chlorobenzyl)-1-(furan-3-yl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C17H18ClN7O3
  1
1
IC50 = 1870 nM
 Bioactivity Info 
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CP0374102
 Compound Info 
1-(2-(5-butyl-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C18H27N7O3
  1
1
IC50 = 2180 nM
 Bioactivity Info 
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CP0506014
 Compound Info 
1-(2-(1-(4-methoxybenzyl)-4,6-dioxo-5-phenethyl-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O3
  1
1
IC50 = 2500 nM
 Bioactivity Info 
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CP0473761
 Compound Info 
1-(2-(5-(furan-2-yl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C18H21N7O4
  1
1
IC50 = 2590 nM
 Bioactivity Info 
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CP0481672
 Compound Info 
1-(2-(5-(4-fluorobenzyl)-1-(4-methoxyphenethyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H26FN7O3
  1
1
IC50 = 2860 nM
 Bioactivity Info 
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CP0396957
 Compound Info 
1-(2-(5-(4-methoxybenzyl)-1-((4-methoxycyclohexyl)methyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H33N7O4
  1
1
IC50 = 3260 nM
 Bioactivity Info 
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CP0473763
 Compound Info 
1-(2-(5-(3-methoxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
  1
1
IC50 = 3690 nM
 Bioactivity Info 
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CP0538028
 Compound Info 
1-(2-(1-benzyl-5-(4-chloro-2-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H22ClN7O2
  1
1
IC50 = 4780 nM
 Bioactivity Info 
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CP0473764
 Compound Info 
1-(2-(5-(3,4-dichlorobenzyl)-1-hexyl-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C19H27Cl2N7O2
  1
1
IC50 = 6510 nM
 Bioactivity Info 
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CP0418706
 Compound Info 
1-(2-(5-(2-methoxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0439771
 Compound Info 
1-(2-(5-(4-fluorobenzyl)-1-(4-nitrobenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H21FN8O4
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0439774
 Compound Info 
1-(2-(5-benzyl-1-(4-fluorobenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H22FN7O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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Cell Line ID: CL000278 , RBL-2H3
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Prokineticin receptor-1 (PROKR1) )
Target Type Patented-recorded Target