General Information of the Protein
Protein ID
PT04494
Protein Name
Transient receptor potential cation channel subfamily V member 3
Secondarily
Protein Name
Vanilloid receptor-like 3
Gene Name
TRPV3
Sequence
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Transient receptor potential channel
Function
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
    Show/Hide
Uniprot ID
Primary ID:
Q8NET8

Secondarily ID:
Q8NDW7
Q8NET9
Q8NFH2
    Show/Hide
HGNC ID
HGNC:18084
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0395902
 Compound Info 
6-methyl-5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C15H11F3N2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395903
 Compound Info 
6-(trifluoromethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C15H8F6N2O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440768
 Compound Info 
5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C14H9F3N2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440771
 Compound Info 
6-chloro-5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C14H8ClF3N2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447248
 Compound Info 
6-(cyclopropylmethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C18H15F3N2O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447265
 Compound Info 
6-methoxy-5-[2-(trifluoromethyl)phenyl]-1H-indazole
   Show/Hide
C15H11F3N2O
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000058 , T-REx-293
 Cell Line Info 
Cell Line ID: CL000308 , T-REx-CHO
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Transient receptor potential cation channel V3 (TRPV3) )
Target Type Clinical trial Target