General Information of the Protein
Protein ID
PT04434
Protein Name
Lutropin-choriogonadotropic hormone receptor
Secondarily
Protein Name
Luteinizing hormone receptor
Gene Name
LHCGR
Secondarily
Gene Name
LCGR
LGR2
LHRHR
Sequence
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Glycohormone receptor
>
Glycohormone receptor
Function
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
    Show/Hide
Uniprot ID
Primary ID:
P22888

Secondarily ID:
Q14751
Q15996
Q9UEW9
    Show/Hide
Ensembl ID
ENSG00000138039
HGNC ID
HGNC:6585
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0187099
 Compound Info 
N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-5-[2-(4-tert-butylphenyl)-5-pyridin-3-ylpyrazol-3-yl]pentanamide
   Show/Hide
C32H37N5O3
  1
1
EC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0449761
 Compound Info 
5-[2-(4-tert-butylphenyl)-5-pyridin-3-ylpyrazol-3-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
   Show/Hide
C31H36N4O2
  1
1
EC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427913
 Compound Info 
N-[(2S)-1-amino-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]-6-[[2-(4-tert-butylphenyl)-5-pyridin-2-ylpyrazol-3-yl]amino]hexanamide
   Show/Hide
C33H40N6O3
  1
1
EC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427911
 Compound Info 
N-[(1S)-2-amino-1-(4-hydroxyphenyl)-2-oxoethyl]-6-[[2-(4-tert-butylphenyl)-5-pyridin-2-ylpyrazol-3-yl]amino]hexanamide
   Show/Hide
C32H38N6O3
  1
1
EC50 = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0485195
 Compound Info 
(S)-N-(4-amino-4-oxo-1-phenylbutan-2-yl)-5-(1-(4-tert-butylphenyl)-3-(pyridin-4-yl)-1H-pyrazol-5-yl)pentanamide
   Show/Hide
C33H39N5O2
  1
1
EC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434113
 Compound Info 
(S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(1-(4-tert-butylphenyl)-3-(pyridin-4-yl)-1H-pyrazol-5-yl)pentanamide
   Show/Hide
C32H37N5O3
  1
1
EC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0427912
 Compound Info 
N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-[2-(4-tert-butylphenyl)-5-isoquinolin-3-ylpyrazol-3-yl]benzamide
   Show/Hide
C38H35N5O3
  1
1
EC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489276
 Compound Info 
(S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(1-(4-tert-butylphenyl)-5-(pyridin-4-yl)-1H-pyrazol-3-yl)pentanamide
   Show/Hide
C32H37N5O3
  1
1
EC50 = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464220
 Compound Info 
N-[(2S)-1-amino-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]-1-oxopropan-2-yl]-5-[[2-(4-tert-butylphenyl)-5-pyridin-3-ylpyrazol-3-yl]amino]pentanamide
   Show/Hide
C36H46N6O3
  1
1
EC50 = 12100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0501824
 Compound Info 
(S)-2-{3-[2-(4-tert-butyl-phenyl)-5-pyridin-3-yl-2H-pyrazol-3-yl]-propionylamino}-3-(4-hydroxy-phenyl)-propionamide
   Show/Hide
C30H33N5O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524282
 Compound Info 
(S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(1-(4-tert-butylphenyl)-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)butanamide
   Show/Hide
C31H36N6O3
  1
1
EC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL001022 , HEK293EM
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0115536
 Compound Info 
5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-methylsulfanylthieno[2,3-d]pyrimidine-6-carboxamide
   Show/Hide
C19H22N4O2S2
  1
1 EC50 = 220 nM
CP0187099
 Compound Info 
N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-5-[2-(4-tert-butylphenyl)-5-pyridin-3-ylpyrazol-3-yl]pentanamide
   Show/Hide
C32H37N5O3
  1
1 Ki = 0.311 nM
Clinical Information about the Protein
Target 1 ( Luteinizing hormone receptor (LHCGR) )
Target Type Successful Target
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT00670 Luteinizing hormone/choriogondaotropin receptor Macaca fascicularis, Crab-eating macaque, Cynomolgus monkey
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT07470 Lutropin-choriogonadotropic hormone receptor Mus musculus, Mouse
 Protein Info