General Information of the Protein
| Protein ID |
PT04012
|
||||
|---|---|---|---|---|---|
| Protein Name |
Excitatory amino acid transporter 1
|
||||
| Secondarily Protein Name |
Sodium-dependent glutamate/aspartate transporter 1
Solute carrier family 1 member 3
|
||||
| Gene Name |
SLC1A3
|
||||
| Secondarily Gene Name |
EAAT1
GLAST
GLAST1
|
||||
| Sequence |
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
Show/Hide
|
||||
| Organism |
Homo sapiens, Human
|
||||
| Protein Classification |
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC01 family of amino acid transporters
|
||||
| Function |
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Show/Hide
|
||||
| Uniprot ID |
Show/Hide
|
||||
| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Cell membrane
|
||||
Map of Molecular Bioactivity Related to the Protein
|
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0239579 |
(RS)-2-amino-3-(1-hydroxy-1,2,3-triazol-5-yl)propionate
Show/Hide
|
C5H8N4O3
|
1 |
| 1 | IC50 = 100000 nM | ||
|---|---|---|---|
Clinical Information about the Protein
Target 1 ( Excitatory amino acid transporter 1 (SLC1A3) )
| Target Type | Literature-reported Target | ||||
|---|---|---|---|---|---|
Target 2 ( HUMAN excitatory amino acid transporter 1 (EAAT1) )
| Target Type | Unknown Type Target | ||||
|---|---|---|---|---|---|