General Information of the Compound
Compound ID
CP0417401
Compound Name
CAS_868359-05-1
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Synonyms
WAY-213,613
WAY-213613
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Structure
Formula
C16H13BrF2N2O4
Molecular Weight
415.19
Canonical SMILES
N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O
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InChI
InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1
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InChIKey
BNYDDAAZMBUFRG-ZDUSSCGKSA-N
Physicochemical Property
logP
3.2601
Rotatable Bonds
6
Heavy Atom Count
25
Polar Areas
101.65
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11531745
SID: 16633786
ChEMBL ID
CHEMBL1628669
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04012, Excitatory amino acid transporter 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT03541, Excitatory amino acid transporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
Protein ID: PT03879, Excitatory amino acid transporter 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( WAY-213613 )
Drug Name WAY-213613
Target(s)
Excitatory amino acid transporter 2 (SLC1A2)
Inhibitor