General Information of the Compound
Compound ID
CP0448604
Compound Name
(2S)-2-amino-4-[4-(3-chloro-4-fluorophenyl)-2-ethylanilino]-4-oxobutanoic acid
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Structure
Formula
C18H18ClFN2O3
Molecular Weight
364.804
Canonical SMILES
CCc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1ccc(F)c(Cl)c1
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InChI
InChI=1S/C18H18ClFN2O3/c1-2-10-7-11(12-3-5-14(20)13(19)8-12)4-6-16(10)22-17(23)9-15(21)18(24)25/h3-8,15H,2,9,21H2,1H3,(H,22,23)(H,24,25)/t15-/m0/s1
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InChIKey
FAAZYFWXJOLYDB-HNNXBMFYSA-N
Physicochemical Property
logP
3.449
Rotatable Bonds
6
Heavy Atom Count
25
Polar Areas
92.42
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71452727
ChEMBL ID
CHEMBL2113111
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04012, Excitatory amino acid transporter 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
Protein ID: PT03541, Excitatory amino acid transporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
Protein ID: PT03879, Excitatory amino acid transporter 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS