General Information of the Protein
Protein ID
PT03817
Protein Name
Membrane primary amine oxidase
Secondarily
Protein Name
Copper amine oxidase
Semicarbazide-sensitive amine oxidase
VP97
Vascular adhesion protein 1
Gene Name
AOC3
Sequence
MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Oxidoreductase
Function
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity).
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Uniprot ID
Primary ID:
O08590

Secondarily ID:
Q497D2
Q5R1T5
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Ensembl ID
ENSG00000131471
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0658461
 Compound Info 
N-[4-(2-{4-[(2-Amino-1H-imidazol-4-yl)methyl]phenyl}ethyl)thiazol-2-yl]acetamide hydrochloride
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C17H20ClN5OS
  1
1
IC50 = 5.1 nM
 Bioactivity Info 
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CP0905705
 Compound Info 
2-Fluoro-3-{3-[(6-methylpyridin-3-yl)oxy]azetidin-1-yl}benzyl-N-carbamimidoylcarbamate (2R,3R)-tartrate
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C22H26FN5O9
  1
1
IC50 = 5.2 nM
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CP0954479
 Compound Info 
4-{4-[5-(3-{[Glycyl(methyl)amino]methyl}phenyl)pyrimidin-2-yl]piperazin-1-yl}benzoic acid dihydrochloride
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C25H30Cl2N6O3
  1
1
IC50 = 10 nM
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CP0200164
 Compound Info 
N-[4-[2-[4-(diaminomethylideneamino)phenyl]ethyl]-1,3-thiazol-2-yl]acetamide
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C14H17N5OS
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0904605
 Compound Info 
3-Chloro-4-{4-[5-(3-{[glycyl(methyl)amino]methyl}phenyl)pyrimidin-2-yl]piperazin-1-yl}benzoic acid dihydrochloride
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C25H29Cl3N6O3
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0915844
 Compound Info 
N-Methyl-N-{3-[2-(morpholin-4-yl)pyrimidin-5-yl]benzyl}glycinamide (2R,3R)-tartrate
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C22H29N5O8
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0465625
 Compound Info 
N-[4-[2-[4-(diaminomethylideneamino)phenyl]ethyl]-5-[(3-methylsulfonylphenyl)methyl]-1,3-thiazol-2-yl]acetamide
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C22H25N5O3S2
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0949294
 Compound Info 
N-[4-(2-{4-[(2-Amino-1H-imidazol-4-yl)ethyl]phenyl}ethyl)thiazol-2-yl]acetamide hydrochloride
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C18H22ClN5OS
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0887128
 Compound Info 
N-(Biphenyl-3-ylmethyl)glycinamide hydrochloride
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C15H17ClN2O
  1
1
IC50 = 23 nM
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CP0906413
 Compound Info 
N-Methyl-N-{[4'-(morpholin-4-yl)biphenyl-3-yl]methyl}glycinamide ethanedioate
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C22H27N3O6
  1
1
IC50 = 36 nM
 Bioactivity Info 
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CP0946801
 Compound Info 
N-Methyl-N-{3-[6-(morpholin-4-yl)pyridin-3-yl]benzyl}glycinamide (2R,3R)-tartrate
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C23H30N4O8
  1
1
IC50 = 37 nM
 Bioactivity Info 
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CP0900911
 Compound Info 
N-(4-[2-(4-{[Amino(imino)methyl]amino}phenyl)ethyl]-5-{4-[(dimethylamino)sulfonyl]benzyl}-1,3-thiazol-2-yl)acetamide hydrochloride
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C23H29ClN6O3S2
  1
1
IC50 = 50 nM
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CP0900663
 Compound Info 
N-[(4'-Chlorobiphenyl-3-yl)methyl]-N-methylglycinamide hydrochloride
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C16H18Cl2N2O
  1
1
IC50 = 53 nM
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CP0456931
 Compound Info 
N-[4-[2-[4-(diaminomethylideneamino)phenyl]ethyl]-5-[(4-methylsulfonylphenyl)methyl]-1,3-thiazol-2-yl]acetamide
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C22H25N5O3S2
  1
1
IC50 = 72 nM
 Bioactivity Info 
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CP0940284
 Compound Info 
N-(4-[2-(4-{[Amino(imino)methyl]amino}phenyl)ethyl]-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide hydrochloride
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C23H28ClN5O3S2
  1
1
IC50 = 92 nM
 Bioactivity Info 
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CP0900912
 Compound Info 
N-{4-[2-(4-{[Amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamidehydrochloride
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C21H25ClN6O3S2
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0573219
 Compound Info 
2-amino-N-methyl-N-[(3-phenylphenyl)methyl]acetamide
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C16H18N2O
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0867965
 Compound Info 
N-Methyl-N-({5-[4-(morpholin-4-yl)phenyl]pyridin-3-yl}methyl)glycinamide (2R,3R)-tartrate
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C23H30N4O8
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0857664
 Compound Info 
N-(4-{2-[4-(2-Amino-1H-imidazol-4-yl)phenyl]ethyl}thiazol-2-yl)acetamide hydrochloride
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C16H18ClN5OS
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0852596
 Compound Info 
N-Methyl-N-({6-[4-(morpholin-4-yl)phenyl]pyridin-2-yl}methyl)glycinamide dihydrochloride
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C19H26Cl2N4O2
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0900922
 Compound Info 
N-{4-[2-(4-{[Amino(imino)methyl]amino}phenyl)ethyl]-5-benzyl-1,3-thiazol-2-yl}acetamide hydrochloride
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C21H24ClN5OS
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0413873
 Compound Info 
5-benzyl-1H-imidazol-2-amine
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C10H11N3
  1
1
IC50 = 420 nM
 Bioactivity Info 
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CP0940898
 Compound Info 
Methyl 4-({2-(acetylamino)-4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoatehydrochloride
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C23H26ClN5O3S
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0386177
 Compound Info 
N-[4-[2-[4-(diaminomethylideneamino)phenyl]ethyl]-5-[(4-methylsulfanylphenyl)methyl]-1,3-thiazol-2-yl]acetamide
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C22H25N5OS2
  1
1
IC50 = 850 nM
 Bioactivity Info 
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CP0014376
 Compound Info 
1H-1,3-benzodiazol-2-amine
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C7H7N3
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0418892
 Compound Info 
4-methyl-1H-benzimidazol-2-amine
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C8H9N3
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0901202
 Compound Info 
N-{4-[2-(4-{[Amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1,3-thiazol-2-yl}acetamidehydrochloride
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C21H24ClN5O3S2
  1
1
IC50 = 3500 nM
 Bioactivity Info 
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CP0389020
 Compound Info 
5-(2-phenylethyl)-1H-imidazol-2-amine
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C11H13N3
  1
1
IC50 = 4800 nM
 Bioactivity Info 
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CP0857184
 Compound Info 
N-{1-[2-(4-Carbamimidamidophenyl)ethyl]-5-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}acetamidehydrochloride
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C21H25ClN6O3S
  1
1
IC50 = 9200 nM
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CP0418891
 Compound Info 
6-methyl-1H-benzimidazol-2-amine
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C8H9N3
  1
1
IC50 = 9300 nM
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CP0509177
 Compound Info 
5-phenyl-1H-imidazol-2-amine
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C9H9N3
  1
1
IC50 = 44000 nM
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CP0946353
 Compound Info 
1H-indol-2-amine hydrochloride
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C8H9ClN2
  1
1
IC50 = 63000 nM
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CP0222047
 Compound Info 
1-phenylguanidine
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C7H9N3
  1
1
IC50 = 78000 nM
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CP0545959
 Compound Info 
1-methyl-1H-1,3-benzodiazol-2-amine
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C8H9N3
  1
1
IC50 = 80000 nM
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CP0946352
 Compound Info 
1H-imidazol-2-amine hemisulfate
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C3H7N3O4S
  1
1
IC50 = 90000 nM
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CP0456932
 Compound Info 
N-[1-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazol-3-yl]acetamide
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C18H16FN3O3S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0057720
 Compound Info 
1,3-benzothiazol-2-amine
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C7H6N2S
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0142371
 Compound Info 
1H-1,3-benzodiazole
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C7H6N2
  1
1
IC50 > 100000 nM
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CP0245992
 Compound Info 
quinazolin-2-amine
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C8H7N3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0755319
 Compound Info 
(1H-benzo[d]imidazol-2-yl)methanamine dihydrochloride
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C8H11Cl2N3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0857663
 Compound Info 
1-Phenyl-imidazolidin-2-ylideneamine hydrobromide
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C9H12BrN3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0906015
 Compound Info 
N-phenyl-4,5-dihydro-1H-imidazol-2-amine hydrochloride
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C9H12ClN3
  1
1
IC50 > 100000 nM
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Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02562 Membrane primary amine oxidase Homo sapiens, Human
 Protein Info