General Information of the Protein
Protein ID
PT03814
Protein Name
C-X-C chemokine receptor type 5
Secondarily
Protein Name
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Gene Name
CXCR5
Secondarily
Gene Name
BLR1
MDR15
Sequence
MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CXC chemokine receptor
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
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Uniprot ID
Primary ID:
P32302

Secondarily ID:
Q14811
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Ensembl ID
ENSG00000160683
HGNC ID
HGNC:1060
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000194 , RBL-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0967634
 Compound Info 
4,5-Difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H21F2NO3
  1
1
IC50 = 5 nM
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CP0968244
 Compound Info 
(S)-5-fluoro-2-(2-isobutyl-3-methylbenzamido)-2,3-dihydro-1H-indene-2-carboxylic acid
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C22H24FNO3
  1
1
IC50 = 7 nM
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CP0903277
 Compound Info 
5-Chloro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H22ClNO3
  1
1
IC50 = 9 nM
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CP0967636
 Compound Info 
5-Fluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H22FNO3
  1
1
IC50 = 11 nM
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CP0967257
 Compound Info 
2-(2-Cyclopent-1-enyl-3-methyl-benzoylamino)-5-fluoro-indan-2-carboxylic acid
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C23H22FNO3
  1
1
IC50 = 13 nM
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CP0954262
 Compound Info 
2-(2-Isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H25NO3
  1
1
IC50 = 14 nM
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CP0862305
 Compound Info 
5-fluoro-2-(2-isobutyl-3-methylbenzamido)-2,3-dihydro-1H-indene-2-carboxylic acid
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C22H24FNO3
  1
1
IC50 = 15 nM
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CP0968246
 Compound Info 
5,6-Difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H21F2NO3
  1
1
IC50 = 15 nM
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CP0866317
 Compound Info 
5,6-Difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H23F2NO3
  1
1
IC50 = 17 nM
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CP0866319
 Compound Info 
2-(3-Methyl-2-propyl-benzoylamine)-indan-2-carboxylic acid
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C21H23NO3
  1
1
IC50 = 23 nM
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CP0850469
 Compound Info 
2-[2-(2-Methyl-propenyl)-3-trifluoromethyl-benzoylamino]-indan-2-carboxylic acid
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C22H20F3NO3
  1
1
IC50 = 26 nM
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CP0953000
 Compound Info 
(R)-5-fluoro-2-(2-isobutyl-3-methylbenzamido)-2,3-dihydro-1H-indene-2-carboxylic acid
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C22H24FNO3
  1
1
IC50 = 30 nM
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CP0967637
 Compound Info 
2-[3-Methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H23NO3
  1
1
IC50 = 33 nM
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CP0954221
 Compound Info 
4,7-Difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C22H21F2NO3
  1
1
IC50 = 38 nM
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CP0968245
 Compound Info 
5,6-Difluoro-2-(3-methyl-2-propyl-benzoylamino)-indan-2-carboxylic acid
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C21H21F2NO3
  1
1
IC50 = 45 nM
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CP0967635
 Compound Info 
(E)-5-fluoro-2-(3-methyl-2-(prop-1-enyl)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid
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C21H22FNO3
  1
1
IC50 = 47 nM
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CP0967638
 Compound Info 
2-(2-Cyclopent-1-enyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C23H23NO3
  1
1
IC50 = 56 nM
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CP0953607
 Compound Info 
2-[2-(2-Cyclopropyl-ethyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid
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C23H25NO3
  1
1
IC50 = 97 nM
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CP0896453
 Compound Info 
(Z)-2-(3-methyl-2-(pent-1-enyl)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid
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C23H25NO3
  1
1
IC50 = 99 nM
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CP0967957
 Compound Info 
2-(2-Isopropoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C21H23NO4
  1
1
IC50 = 105 nM
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CP0850731
 Compound Info 
5-Fluoro-2-[3-methyl-2-((E)-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C21H20FNO3
  1
1
IC50 = 200 nM
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CP0953002
 Compound Info 
2-[3-Methyl-2-(1-propenyl)-benzoylamino]-indan-2-carboxylic acid
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C21H21NO3
  1
1
IC50 = 232 nM
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CP0967641
 Compound Info 
2-(3,5-Dichloro-2-cyclobutoxy-benzoylamino)-5-fluoro-indan-2-carboxylic acid
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C21H18Cl2FNO4
  1
1
IC50 = 268 nM
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CP0952120
 Compound Info 
5-Fluoro-2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C21H20FNO3
  1
1
IC50 = 298 nM
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CP0951849
 Compound Info 
2-(2-Cyclobutoxy-3-methyl-benzoylamino)-5-fluoro-indan-2-carboxylic acid
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C22H22FNO4
  1
1
IC50 = 380 nM
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CP0866318
 Compound Info 
2-[3-Methyl-2-((E)-pent-1-enyl)-benzoylamino]-indan-2-carboxylic acid
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C23H25NO3
  1
1
IC50 = 446 nM
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CP0967261
 Compound Info 
2-(2-Cyclobutoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H23NO4
  1
1
IC50 = 470 nM
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CP0952123
 Compound Info 
2-(2-Allyloxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C21H21NO4
  1
1
IC50 = 493 nM
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CP0896452
 Compound Info 
2-(2-Cyclopentyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C23H25NO3
  1
1
IC50 = 533 nM
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CP0862307
 Compound Info 
5-Fluoro-2-(2-isopropoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C21H22FNO4
  1
1
IC50 = 537 nM
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CP0950994
 Compound Info 
2-[(5,6,7,8-Tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C21H21NO3
  1
1
IC50 = 675 nM
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CP0954261
 Compound Info 
2-(2-Cyclohex-1-enyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C24H25NO3
  1
1
IC50 = 1050 nM
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CP0967956
 Compound Info 
2-(2-sec-Butoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H25NO4
  1
1
IC50 = 1080 nM
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CP0904281
 Compound Info 
2-(3-Methyl-2-pentyl-benzoylamino)-indan-2-carboxylic acid
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C23H27NO3
  1
1
IC50 = 2300 nM
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CP0952121
 Compound Info 
1,3-Dimethyl-5-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-5,6-dihydro-4H-cyclopenta[c]thiophene-5-carboxylic acid
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C21H23NO3S
  1
1
IC50 = 2850 nM
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CP0953008
 Compound Info 
2-(2-Cyclopropylmethoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H23NO4
  1
1
IC50 = 2930 nM
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CP0967955
 Compound Info 
2-(2-Allyloxy-3-chloro-benzoylamino)-indan-2-carboxylic acid
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C20H18ClNO4
  1
1
IC50 = 3650 nM
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CP0850470
 Compound Info 
2-[2-(1-Ethyl-butyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid
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C24H29NO3
  1
1
IC50 = 3870 nM
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CP0867857
 Compound Info 
2-[(Naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C21H17NO3
  1
1
IC50 = 5450 nM
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CP0874162
 Compound Info 
2-[(5,6,7,8-Tetrahydro-naphthalene-1-carbonyl)-amino]-5-trifluoromethyl-indan-2-carboxylic acid
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C22H20F3NO3
  1
1
IC50 = 6100 nM
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CP0866321
 Compound Info 
2-(2-Cyclobutoxy-3-methyl-benzoylamino)-5-trifluoro-indan-2-carboxylic acid
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C23H22F3NO4
  1
1
IC50 = 7800 nM
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CP0951810
 Compound Info 
2-[2-(-2-Cyclopropyl-vinyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid
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C23H23NO3
  1
1
IC50 = 8200 nM
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CP0951852
 Compound Info 
5-Methoxy-2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C22H23NO4
  1
1
IC50 = 9500 nM
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CP0951419
 Compound Info 
5-Cyano-2-(2-cyclobutoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C23H22N2O4
  1
1
IC50 = 10150 nM
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CP0867856
 Compound Info 
2-[(4-Fluoro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C21H16FNO3
  1
1
IC50 = 13000 nM
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CP0950995
 Compound Info 
2-(2-Allyloxy-3,5-dichloro-benzenesulfonylamino)-indan-2-carboxylic acid
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C19H17Cl2NO5S
  1
1
IC50 = 13000 nM
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CP0951850
 Compound Info 
2-(2-Isopropoxy-3-methyl-benzoylamino)-5-trifluoromethyl-indan-2-carboxylic acid
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C22H22F3NO4
  1
1
IC50 = 14750 nM
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CP0951811
 Compound Info 
2-[2-(-1-Ethyl-but-1-enyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid
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C24H27NO3
  1
1
IC50 = 15250 nM
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CP0850735
 Compound Info 
2-(3,5-Dichloro-2-isopropoxy-benzenesulfonylamino)-indan-2-carboxylic acid
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C19H19Cl2NO5S
  1
1
IC50 = 16000 nM
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CP0951851
 Compound Info 
5-(2-Isopropoxy-3-methyl-benzoylamino)-1,3-dimethyl-5,6-dihydro-4H-cyclopenta[c]thiophene-5-carboxylic acid
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C21H25NO4S
  1
1
IC50 = 17350 nM
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CP0900314
 Compound Info 
2-(2-Isopropoxy-3-methyl-benzoylamino)-5-methoxy-indan-2-carboxylic acid
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C22H25NO5
  1
1
IC50 = 18200 nM
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CP0900313
 Compound Info 
2-(3-Methyl-2-pent-1-ynyl-benzoylamino)-indan-2-carboxylic acid
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C23H23NO3
  1
1
IC50 = 19300 nM
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CP0952122
 Compound Info 
2-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C23H21NO4
  1
1
IC50 = 19600 nM
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CP0967639
 Compound Info 
5-Cyano-2-(2-isopropoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H22N2O4
  1
1
IC50 = 20500 nM
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CP0953007
 Compound Info 
4-(2-Isopropoxy-3-methyl-benzoylamino)-tetrahydro-thiopyran-4-carboxylic acid
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C17H23NO4S
  1
1
IC50 = 24000 nM
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CP0951421
 Compound Info 
2-(2-Isopropoxy-3-methyl-benzoylamino)-5,6-dimethyl-indan-2-carboxylic acid
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C23H27NO4
  1
1
IC50 = 27000 nM
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CP0850732
 Compound Info 
5-Carbamoyl-2-(2-cyclobutoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C23H24N2O5
  1
1
IC50 > 30000 nM
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CP0850733
 Compound Info 
5-Carbamoyl-2-(2-isopropoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid
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C22H24N2O5
  1
1
IC50 > 30000 nM
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CP0861599
 Compound Info 
5-Cyano-2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C22H20N2O3
  1
1
IC50 = 30000 nM
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CP0862306
 Compound Info 
2-(2-Cyclobutoxy-3-methyl-benzoylamino)-indan-2,5-dicarboxylic acid
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C23H23NO6
  1
1
IC50 > 30000 nM
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CP0866320
 Compound Info 
2-[(5,6,7,8-Tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2,5-dicarboxylic acid
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C22H21NO5
  1
1
IC50 > 30000 nM
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CP0869103
 Compound Info 
2-(2-Isopropoxy-3-methyl-benzoylamino)-indan-2,5-dicarboxylic acid
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C22H23NO6
  1
1
IC50 > 30000 nM
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CP0874163
 Compound Info 
2-[(Quinoxaline-2-carbonyl)-amino]-indan-2-carboxylic acid
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C19H15N3O3
  1
1
IC50 > 30000 nM
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CP0903278
 Compound Info 
2-[(1H-Indole-7-carbonyl)-amino]-indan-2-carboxylic acid
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C19H16N2O3
  1
1
IC50 > 30000 nM
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CP0903279
 Compound Info 
2-[(Isoquinoline-4-carbonyl)-amino]-indan-2-carboxylic acid
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C20H16N2O3
  1
1
IC50 > 30000 nM
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CP0903280
 Compound Info 
2-(Quinoline-8-sulfonylamino)-indan-2-carboxylic acid
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C19H16N2O4S
  1
1
IC50 > 30000 nM
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CP0950993
 Compound Info 
2-[(6-Fluoro-4H-benzo[1,3]dioxine-8-carbonyl)-amino]-indan-2-carboxylic acid
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C19H16FNO5
  1
1
IC50 = 30000 nM
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CP0951853
 Compound Info 
2-[(2,3-Dihydro-benzo[1,4]dioxine-5-carbonyl)-amino]-indan-2-carboxylic acid
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C19H17NO5
  1
1
IC50 > 30000 nM
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CP0952119
 Compound Info 
2-[(2-Isopropoxy-3-methyl-benzoyl)-methyl-amino]-indan-2-carboxylic acid
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C22H25NO4
  1
1
IC50 > 30000 nM
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CP0967258
 Compound Info 
5-Carbamoyl-2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid
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C22H22N2O4
  1
1
IC50 > 30000 nM
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CP0967259
 Compound Info 
2-[(1,2,3,4-Tetrahydro-quinoline-8-carbonyl)-amino]-indan-2-carboxylic acid
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C20H20N2O3
  1
1
IC50 > 30000 nM
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CP0967260
 Compound Info 
2-[(1H-Indole-4-carbonyl)-amino]-indan-2-carboxylic acid
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C19H16N2O3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0967640
 Compound Info 
2-[(Quinoline-8-carbonyl)-amino]-indan-2-carboxylic acid
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C20H16N2O3
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000739 , U87.CD4.CCR5
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( C-X-C chemokine receptor type 5 (CXCR5) )
Target Type Clinical trial Target