General Information of the Protein
| Protein ID |
PT03805
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| Protein Name |
Sodium/hydrogen exchanger 1
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| Secondarily Protein Name |
APNH
Na(+)/H(+) antiporter
amiloride-sensitive
Na(+)/H(+) exchanger 1
Solute carrier family 9 member 1
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| Gene Name |
SLC9A1
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| Secondarily Gene Name |
APNH1
NHE1
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| Sequence |
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC09 family of sodium/hydrogen exchangers
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| Function |
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:7110335, PubMed:7603840, PubMed:11532004, PubMed:11350981, PubMed:15035633, PubMed:14680478, PubMed:17073455, PubMed:22020933, PubMed:27650500, PubMed:15677483, PubMed:32130622, PubMed:17493937). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:8901634, PubMed:12947095, PubMed:15096511, PubMed:22020933). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511).
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cell membrane
Basolateral cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000429 , AP-1
Cell Line ID: CL000026 , CHO-K1
Cell Line ID: CL000007 , HT-29
Cell Line ID: CL000658 , LAP1
Cell Line ID: CL000548 , PS120
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Sodium/hydrogen exchanger 1 (SLC9A1) )
| Target Type | Clinical trial Target | ||||
|---|---|---|---|---|---|
| Disease | 3 Target-related Diseases | 3 | |||
| 1 | Angina pectoris [ICD-11: BA40] | ||||
| 2 | Cardiac arrhythmias [ICD-11: BC9Z] | ||||
| 3 | Heart arrhythmia [ICD-11: BC65] | ||||
| Discontinued Drug(s) | 3 Discontinued Drugs | 3 | |||
| 1 | CARIPORIDE | Discontinued in Phase 2 | |||
| 2 | ENIPORIDE | Discontinued in Phase 2 | |||
| 3 | HOE-694 | Terminated | |||
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT04400 | Sodium/hydrogen exchanger 1 | Rattus norvegicus, Rat | |
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