General Information of the Protein
Protein ID
PT03765
Protein Name
Estrogen-related receptor gamma
Secondarily
Protein Name
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene Name
ESRRG
Secondarily
Gene Name
Err3
Kiaa0832
Nr3b3
Sequence
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group B
>
Nuclear hormone receptor subfamily 3 group B member 3
Function
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.
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Uniprot ID
Primary ID:
P62509

Secondarily ID:
O75454
O96021
Q8CHC9
Q9R1F3
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Ensembl ID
ENSG00000196482
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0391805
 Compound Info 
[4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-3-methyl-2-phenylbut-1-enyl]phenyl] acetate
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C29H33NO3
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0411193
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-3-methyl-2-phenylbut-1-enyl]phenol
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C27H31NO2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454776
 Compound Info 
[4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenyl] acetate
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C29H33NO4
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0481181
 Compound Info 
[4-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-4-methyl-2-phenylpent-1-enyl]phenyl] acetate
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C30H35NO4
  1
1
IC50 = 350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0648741
 Compound Info 
4-Hydroxytamoxifen
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C26H29NO2
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454777
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-4-methyl-2-phenylpent-1-enyl]phenol
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C28H33NO2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410155
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-hydroxy-4-methyl-2-phenylpent-1-enyl]phenol
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C28H33NO3
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0176271
 Compound Info 
4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol
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C27H31NO3
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410156
 Compound Info 
methyl (Z)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-hydroxyphenyl)-2-methyl-4-phenylpent-4-enoate
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C29H33NO4
  1
1
IC50 = 2780 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0481182
 Compound Info 
methyl (Z)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-hydroxyphenyl)-4-phenylpent-4-enoate
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C28H31NO4
  1
1
IC50 = 3500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526262
 Compound Info 
methyl 5,5-bis(4-hydroxyphenyl)-2-methyl-4-phenylpent-4-enoate
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C25H24O4
  1
1
IC50 = 5500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454775
 Compound Info 
methyl 5,5-bis(4-hydroxyphenyl)-4-phenylpent-4-enoate
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C24H22O4
  1
1
IC50 = 6500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT03374 Estrogen-related receptor gamma Homo sapiens, Human
 Protein Info