General Information of the Protein
Protein ID
PT03374
Protein Name
Estrogen-related receptor gamma
Secondarily
Protein Name
ERR gamma-2
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene Name
ESRRG
Secondarily
Gene Name
ERR3
ERRG2
KIAA0832
NR3B3
Sequence
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group B
>
Nuclear hormone receptor subfamily 3 group B member 3
Function
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
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Uniprot ID
Primary ID:
P62508

Secondarily ID:
A8K4I0
A8K6I2
B3KY84
E9PGB7
F8W8J3
O75454
O96021
Q68DA0
Q6P274
Q6PK28
Q6TS38
Q9R1F3
Q9UNJ4
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Ensembl ID
ENSG00000196482
HGNC ID
HGNC:3474
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000192 , AD-293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0164237
 Compound Info 
4-[(E)-5-hydroxy-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol;dihydrochloride
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C30H38Cl2N2O2
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0096836
 Compound Info 
(Z)-5-[4-(4-ethylpiperazin-1-yl)phenyl]-5-(4-methylphenyl)-4-phenylpent-4-en-1-ol;dihydrochloride
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C30H38Cl2N2O
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0117254
 Compound Info 
(Z)-5-(4-methylphenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C31H40Cl2N2O
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0344043
 Compound Info 
(E)-5-(3-bromophenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C30H37BrCl2N2O
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0143014
 Compound Info 
3-[(E)-5-hydroxy-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol;dihydrochloride
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C30H38Cl2N2O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0131412
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-fluoro-2-phenylpent-1-enyl]phenol;hydrochloride
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C27H31ClFNO2
  1
1
IC50 = 48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133940
 Compound Info 
4-[(Z)-1-[4-[3-(dimethylamino)propoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol;hydrochloride
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C28H34ClNO3
  1
1
IC50 = 58 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536297
 Compound Info 
(E)-5-(4-bromophenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C30H37BrCl2N2O
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0060960
 Compound Info 
(Z)-5-(4-methylphenyl)-4-phenyl-5-(4-piperazin-1-ylphenyl)pent-4-en-1-ol;dihydrochloride
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C28H34Cl2N2O
  1
1
IC50 = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0060959
 Compound Info 
(Z)-5-(4-methylphenyl)-5-[4-(4-methylpiperazin-1-yl)phenyl]-4-phenylpent-4-en-1-ol;dihydrochloride
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C29H36Cl2N2O
  1
1
IC50 = 69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0739308
 Compound Info 
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-5-hydroxy-2-phenyl-pent-1-enyl]phenol hydrochloride salt
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C27H32ClNO3
  1
1
IC50 = 77 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0132048
 Compound Info 
4-[(Z)-1-[4-[2-(diethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol;hydrochloride
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C29H36ClNO3
  1
1
IC50 = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0197679
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5,5-difluoro-2-phenylpent-1-enyl]phenol;hydrochloride
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C27H30ClF2NO2
  1
1
IC50 = 111 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0316921
 Compound Info 
4-[(Z)-5-hydroxy-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylpent-1-enyl]phenol;hydrochloride
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C26H30ClNO3
  1
1
IC50 = 187 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0182080
 Compound Info 
(Z)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-methylphenyl)-4-phenylpent-4-en-1-ol;hydrochloride
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C28H34ClNO2
  1
1
IC50 = 669 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0182081
 Compound Info 
(E)-5-(4-bromophenyl)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-4-phenylpent-4-en-1-ol;hydrochloride
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C27H31BrClNO2
  1
1
IC50 = 719 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0648741
 Compound Info 
4-Hydroxytamoxifen
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C26H29NO2
  2
1 IC50 = 11 nM
2 IC50 = 13 nM
CP0117254
 Compound Info 
(Z)-5-(4-methylphenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C31H40Cl2N2O
  1
1 IC50 = 17 nM
CP0131412
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5-fluoro-2-phenylpent-1-enyl]phenol;hydrochloride
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C27H31ClFNO2
  1
1 IC50 = 20 nM
CP0536297
 Compound Info 
(E)-5-(4-bromophenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C30H37BrCl2N2O
  1
1 IC50 = 21 nM
CP0096836
 Compound Info 
(Z)-5-[4-(4-ethylpiperazin-1-yl)phenyl]-5-(4-methylphenyl)-4-phenylpent-4-en-1-ol;dihydrochloride
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C30H38Cl2N2O
  1
1 IC50 = 25 nM
CP0060959
 Compound Info 
(Z)-5-(4-methylphenyl)-5-[4-(4-methylpiperazin-1-yl)phenyl]-4-phenylpent-4-en-1-ol;dihydrochloride
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C29H36Cl2N2O
  1
1 IC50 = 26 nM
CP0060960
 Compound Info 
(Z)-5-(4-methylphenyl)-4-phenyl-5-(4-piperazin-1-ylphenyl)pent-4-en-1-ol;dihydrochloride
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C28H34Cl2N2O
  1
1 IC50 = 27 nM
CP0344043
 Compound Info 
(E)-5-(3-bromophenyl)-4-phenyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-4-en-1-ol;dihydrochloride
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C30H37BrCl2N2O
  1
1 IC50 = 33 nM
CP0143014
 Compound Info 
3-[(E)-5-hydroxy-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol;dihydrochloride
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C30H38Cl2N2O2
  1
1 IC50 = 35 nM
CP0164237
 Compound Info 
4-[(E)-5-hydroxy-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol;dihydrochloride
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C30H38Cl2N2O2
  1
1 IC50 = 40 nM
CP0133940
 Compound Info 
4-[(Z)-1-[4-[3-(dimethylamino)propoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol;hydrochloride
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C28H34ClNO3
  1
1 IC50 = 90 nM
CP0739308
 Compound Info 
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-5-hydroxy-2-phenyl-pent-1-enyl]phenol hydrochloride salt
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C27H32ClNO3
  1
1 IC50 = 110 nM
CP0182081
 Compound Info 
(E)-5-(4-bromophenyl)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-4-phenylpent-4-en-1-ol;hydrochloride
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C27H31BrClNO2
  1
1 IC50 = 117 nM
CP0132048
 Compound Info 
4-[(Z)-1-[4-[2-(diethylamino)ethoxy]phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol;hydrochloride
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C29H36ClNO3
  1
1 IC50 = 180 nM
CP0316921
 Compound Info 
4-[(Z)-5-hydroxy-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylpent-1-enyl]phenol;hydrochloride
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C26H30ClNO3
  1
1 IC50 = 190 nM
CP0182080
 Compound Info 
(Z)-5-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-methylphenyl)-4-phenylpent-4-en-1-ol;hydrochloride
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C28H34ClNO2
  1
1 IC50 = 270 nM
CP0197679
 Compound Info 
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-5,5-difluoro-2-phenylpent-1-enyl]phenol;hydrochloride
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C27H30ClF2NO2
  1
1 IC50 = 480 nM
CP0174777
 Compound Info 
4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-hydrazide
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C17H18N2O2
  2
1 IC50 = 2000 nM
2 Kd = 5000 nM
Clinical Information about the Protein
Target 1 ( Estrogen-related receptor-gamma (ESRRG) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT03765 Estrogen-related receptor gamma Mus musculus, Mouse
 Protein Info