General Information of the Protein
Protein ID
PT03764
Protein Name
Cathepsin F
Gene Name
CTSF
Sequence
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Cysteine protease
>
Cysteine protease CA clan
>
Cysteine protease C1A family
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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Uniprot ID
Primary ID:
Q9UBX1

Secondarily ID:
B2R964
O95240
Q9NSU4
Q9UKQ5
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Ensembl ID
ENSG00000174080
HGNC ID
HGNC:2531
Subcellular Location
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000972 , HIG-82
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0076419
 Compound Info 
(S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid ((S)-benzyl-cyano-methyl)-amide
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C30H32F3N3O3S
  1
1
IC50 = 0.3 nM
 Bioactivity Info 
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CP0243116
 Compound Info 
(S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide
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C28H26Cl2F3N3O3S
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0255533
 Compound Info 
(S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C31H29F5N4O3S
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0359165
 Compound Info 
(S)-N-((S)-1-cyano-2-(pyridin-4-yl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C29H30F4N4O3S
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0076420
 Compound Info 
1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethylamino)-3-methyl-1-oxobutan-2-ylamino)-2,2,2-trifluoroethyl)biphenyl-4-yl)cyclopropanecarboxamide
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C33H31F4N5O2
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
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CP0294390
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(1-(morpholine-4-carbonyl)cyclopropyl)biphenyl-4-yl)ethylamino)pentanamide
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C37H40F4N4O3
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
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CP0091658
 Compound Info 
(S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-3-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide
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C30H28F4N4O3S
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0294391
 Compound Info 
(S)-2-((S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2,2,2-trifluoroethylamino)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methylpentanamide
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C26H27F4N5O
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
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CP0302971
 Compound Info 
1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-phenylethylamino)-4-fluoro-4-methyl-1-oxopentan-2-ylamino)-2,2,2-trifluoroethyl)biphenyl-4-yl)cyclopropanecarboxamide
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C33H34F4N4O2
  1
1
IC50 = 37 nM
 Bioactivity Info 
   TI
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CP0243115
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(pyridin-4-yl)biphenyl-4-yl)ethylamino)pentanamide
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C34H32F4N4O
  1
1
IC50 = 51 nM
 Bioactivity Info 
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CP0105431
 Compound Info 
(S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-2-((S)-1-(4'-((R)-2,2-difluoro-1-hydroxyethyl)biphenyl-4-yl)-2,2,2-trifluoroethylamino)-3-methylbutanamide
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C31H28F6N4O2
  1
1
IC50 = 56 nM
 Bioactivity Info 
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CP0076422
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-2-((S)-1-(4'-((R)-2,2-difluoro-1-hydroxyethyl)biphenyl-4-yl)-2,2,2-trifluoroethylamino)-4-fluoro-4-methylpentanamide
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C31H31F6N3O2
  1
1
IC50 = 64 nM
 Bioactivity Info 
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CP0076418
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C30H31F4N3O3S
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
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CP0345241
 Compound Info 
(S)-N-((R)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C31H29F5N4O3S
  1
1
IC50 = 76 nM
 Bioactivity Info 
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CP0105430
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-2-cyclopropyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)acetamide
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C29H28F3N3O3S
  1
1
IC50 = 80 nM
 Bioactivity Info 
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CP0294392
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-3-cyclopropyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)propanamide
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C30H30F3N3O3S
  1
1
IC50 = 147 nM
 Bioactivity Info 
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CP0105429
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-3-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide
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C29H30F3N3O3S
  1
1
IC50 = 174 nM
 Bioactivity Info 
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CP0340558
 Compound Info 
(S)-N-(cyanomethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C23H25F4N3O3S
  1
1
IC50 = 547 nM
 Bioactivity Info 
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CP0076421
 Compound Info 
(S)-N-((S)-1-cyano-3,3,3-trifluoropropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C25H26F7N3O3S
  1
1
IC50 = 654 nM
 Bioactivity Info 
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CP0243122
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-3-phenyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)propanamide
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C33H30F3N3O3S
  1
1
IC50 = 769 nM
 Bioactivity Info 
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CP0243114
 Compound Info 
(S)-N-((S)-1-cyano-3-phenylpropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C31H33F4N3O3S
  1
1
IC50 = 3242 nM
 Bioactivity Info 
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CP0091657
 Compound Info 
(S)-N-((S)-cyano(1-phenylcyclopropyl)methyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide
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C32H33F4N3O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0350672
 Compound Info 
(S)-N-((S)-1-cyano-2-phenylethyl)-3,3-dimethyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide
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C30H32F3N3O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Cathepsin F (CTSF) )
Target Type Patented-recorded Target