General Information of the Protein
| Protein ID |
PT03762
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| Protein Name |
Sodium/hydrogen exchanger 3
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| Secondarily Protein Name |
Na(+)/H(+) exchanger 3
Solute carrier family 9 member 3
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| Gene Name |
SLC9A3
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| Secondarily Gene Name |
NHE3
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| Sequence |
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC09 family of sodium/hydrogen exchangers
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| Function |
Plasma membrane Na(+)/H(+) antiporter (PubMed:26358773, PubMed:35613257, PubMed:18829453). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:26358773, PubMed:24622516).
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Apical cell membrane
Cell membrane
Recycling endosome membrane
Early endosome membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000429 , AP-1
Cell Line ID: CL000026 , CHO-K1
Cell Line ID: CL000658 , LAP1
Cell Line ID: CL000422 , OK
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Sodium/hydrogen exchanger 3 (SLC9A3) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 4 Target-related Diseases | 4 | |||
| 1 | Irritable bowel syndrome [ICD-11: DD91.0] | ||||
| 2 | Angina pectoris [ICD-11: BA40] | ||||
| 3 | Cardiac arrhythmias [ICD-11: BC9Z] | ||||
| 4 | Heart arrhythmia [ICD-11: BC65] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Tenapanor | Approved | |||
| Discontinued Drug(s) | 3 Discontinued Drugs | 3 | |||
| 1 | CARIPORIDE | Discontinued in Phase 2 | |||
| 2 | ENIPORIDE | Discontinued in Phase 2 | |||
| 3 | HOE-694 | Terminated | |||
Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT00708 | Sodium/hydrogen exchanger isoform 3 | Sus scrofa, Pig | |
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