Protein Information

General Information of the Protein

Protein ID	PT03733
Protein Name	Nuclear receptor subfamily 1 group I member 3
Secondarily Protein Name	Constitutive activator of retinoid response Constitutive androstane receptor Orphan nuclear receptor MB67
Gene Name	NR1I3
Secondarily Gene Name	CAR
Sequence	MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Transcription factor > Nuclear receptor > Nuclear hormone receptor subfamily 1 > Nuclear hormone receptor subfamily 1 group I > Nuclear hormone receptor subfamily 1 group I member 3
Function	Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Show/Hide
Uniprot ID	Primary ID: Q14994 Secondarily ID: E9PB75 E9PC13 E9PDU3 E9PGH6 E9PH10 E9PHC8 E9PHN4 F1D8Q0 F1D8Q1 Q0VAC9 Q4U0F0 Q5VTW5 Q5VTW6 Q6GZ68 Q6GZ76 Q6GZ77 Q6GZ78 Q6GZ79 Q6GZ82 Q6GZ83 Q6GZ84 Q6GZ85 Q6GZ87 Q6GZ89 Show/Hide
HGNC ID	HGNC:7969
Subcellular Location	Nucleus Cytoplasm Cytoplasm Cytoskeleton

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000109 , COS-1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0245114 Compound Info	(E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine Show/Hide	C19H12Cl3N3OS	1
1	EC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0180452 Compound Info	2-(3-methoxyphenyl)-4-methylsulfanylquinazoline Show/Hide	C16H14N2OS	1
1	EC50 = 4040 nM Bioactivity Info	TI LI LO TS
CP0059925 Compound Info	4-methoxy-2-(3-methoxyphenyl)quinazoline Show/Hide	C16H14N2O2	1
1	EC50 = 4910 nM Bioactivity Info	TI LI LO TS
CP0046495 Compound Info	2-(3-methoxyphenyl)-1H-quinazoline-4-thione Show/Hide	C15H12N2OS	1
1	EC50 = 6120 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0245114 Compound Info	(E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine Show/Hide	C19H12Cl3N3OS	1
1	EC50 = 5 nM
CP0030899 Compound Info	1-[(2-chlorophenyl)-diphenylmethyl]imidazole Show/Hide	C22H17ClN2	3
1	IC50 = 80 nM
2	IC50 = 100 nM
3	Ki = 100 nM

Clinical Information about the Protein

Target 1 ( Orphan nuclear receptor NR1I3 (NR1I3) )