Protein Information

General Information of the Protein

Protein ID	PT03623
Protein Name	Gag-Pol polyprotein
Secondarily Protein Name	Pr160Gag-Pol p2 PR Retropepsin Exoribonuclease H p66 RT
Gene Name	GAG-POL
Sequence	MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLREDLAFLQGKAREFSSEQTRANSPTRRELQVWGRDNNSPSEAGADRQGTVSFNFPQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED Show/Hide
Organism	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2), HIV-1
Protein Classification	Enzyme > Transferase
Function	Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation. Show/Hide
Uniprot ID	Primary ID: P04585 Secondarily ID: O09777 Q9WJC5 Show/Hide
Subcellular Location	Host cell membrane Host endosome Host multivesicular body

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000262 , MT-2

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0470674 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-[bis(2-hydroxyethyl)amino]ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C43H66N2O4	2
1	EC50 = 0.34 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0405454 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[[3-(2-oxopyrrolidin-1-yl)propylamino]methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H64N2O3	3
1	EC50 = 0.68 nM Bioactivity Info	TI LI LO TS
2	EC50 = 2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 1.7 nM Bioactivity Info	TI LI LO TS
CP0470659 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-(1,1-dioxo-1,4-thiazinan-4-yl)ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C43H64N2O4S	2
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.3 nM Bioactivity Info	TI LI LO TS
CP0513629 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[[3-(4-methylpiperazin-1-yl)propylamino]methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H69N3O2	2
1	EC50 = 0.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0472851 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[[[2-(methylamino)acetyl]amino]methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C40H58N2O3	3
1	EC50 = 0.78 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3.8 nM Bioactivity Info	TI LI LO TS
3	IC50 = 8.8 nM Bioactivity Info	TI LI LO TS
CP0393926 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[3-(1,1-dioxo-1,4-thiazinan-4-yl)propylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H66N2O4S	8
1	EC50 = 0.94 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1 nM Bioactivity Info	TI LI LO TS
3	EC50 = 1.7 nM Bioactivity Info	TI LI LO TS
4	EC50 = 2 nM Bioactivity Info	TI LI LO TS
5	EC50 = 7 nM Bioactivity Info	TI LI LO TS
6	EC50 = 15 nM Bioactivity Info	TI LI LO TS
7	EC50 > 4000 nM Bioactivity Info	TI LI LO TS
8	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
CP0394384 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-3a-[[2-(4-sulfamoylphenyl)ethylamino]methyl]-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H62N2O4S	2
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0547758 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[(3-piperidin-1-ylpropylamino)methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H68N2O2	2
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.4 nM Bioactivity Info	TI LI LO TS
CP0472850 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[(2-morpholin-4-ylethylamino)methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C43H64N2O3	2
1	EC50 = 1.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0470671 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[(2-acetamidoethylamino)methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C41H60N2O3	3
1	EC50 = 1.7 nM Bioactivity Info	TI LI LO TS
2	EC50 = 4.2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 3.6 nM Bioactivity Info	TI LI LO TS
CP0394383 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[3-(1,1-dioxo-1,4-thiazinan-4-yl)propyl-methylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H68N2O4S	2
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0472853 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[cyclopropyl-[3-(1,1-dioxo-1,4-thiazinan-4-yl)propyl]amino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C47H70N2O4S	2
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0566677 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[(3-aminopropylamino)methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C40H60N2O2	2
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3.6 nM Bioactivity Info	TI LI LO TS
CP0489812 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-(dimethylamino)ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C41H62N2O2	3
1	EC50 = 2.2 nM Bioactivity Info	TI LI LO TS
2	EC50 = 8.7 nM Bioactivity Info	TI LI LO TS
3	IC50 = 2.5 nM Bioactivity Info	TI LI LO TS
CP0470673 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[2-(dimethylamino)ethylcarbamoyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C41H60N2O3	6
1	EC50 = 2.3 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3 nM Bioactivity Info	TI LI LO TS
3	EC50 = 11 nM Bioactivity Info	TI LI LO TS
4	EC50 = 23 nM Bioactivity Info	TI LI LO TS
5	EC50 = 42 nM Bioactivity Info	TI LI LO TS
6	IC50 = 7.8 nM Bioactivity Info	TI LI LO TS
CP0411287 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[(2-imidazol-1-ylethylamino)methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C42H59N3O2	3
1	EC50 = 2.5 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3.2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0476661 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[3-(2-hydroxyethylamino)propylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C42H64N2O3	2
1	EC50 = 2.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6.7 nM Bioactivity Info	TI LI LO TS
CP0485161 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[(3-hydroxypropylamino)methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C40H59NO3	2
1	EC50 = 2.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0405455 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[(3-morpholin-4-ylpropylamino)methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H66N2O3	3
1	EC50 = 2.8 nM Bioactivity Info	TI LI LO TS
2	EC50 = 8.2 nM Bioactivity Info	TI LI LO TS
3	IC50 = 3.8 nM Bioactivity Info	TI LI LO TS
CP0526356 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-(2-hydroxyethylamino)ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C41H62N2O3	2
1	EC50 = 3.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.42 nM Bioactivity Info	TI LI LO TS
CP0470658 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-(diethylamino)ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C43H66N2O2	2
1	EC50 = 4.3 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0470662 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[[3-(N-methylanilino)propylamino]methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C47H66N2O2	2
1	EC50 = 4.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2.9 nM Bioactivity Info	TI LI LO TS
CP0411286 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[(2-piperazin-1-ylethylamino)methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C43H65N3O2	3
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
2	EC50 = 26 nM Bioactivity Info	TI LI LO TS
3	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0472852 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-(4,4-difluoropiperidin-1-yl)ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H64F2N2O2	2
1	EC50 = 6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0476662 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[2-[di(propan-2-yl)amino]ethylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H70N2O2	2
1	EC50 = 6.7 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4.4 nM Bioactivity Info	TI LI LO TS
CP0518045 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[[2-(4-methylpiperazin-1-yl)ethylamino]methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H67N3O2	3
1	EC50 = 7.7 nM Bioactivity Info	TI LI LO TS
2	EC50 = 23 nM Bioactivity Info	TI LI LO TS
3	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0518044 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-3a-[(2-pyridin-2-ylethylamino)methyl]-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H60N2O2	3
1	EC50 = 8 nM Bioactivity Info	TI LI LO TS
2	EC50 = 16 nM Bioactivity Info	TI LI LO TS
3	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0275785 Compound Info	2,2-Dimethyl-succinic acid 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-carboxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysen-9-yl) ester Show/Hide	C36H56O6	6
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
2	EC50 = 10.4 nM Bioactivity Info	TI LI LO TS
3	EC50 = 74 nM Bioactivity Info	TI LI LO TS
4	EC50 = 970 nM Bioactivity Info	TI LI LO TS
5	EC50 = 1120 nM Bioactivity Info	TI LI LO TS
6	IC50 = 552 nM Bioactivity Info	TI LI LO TS
CP0518047 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[3-carboxypropanoyl-[2-(dimethylamino)ethyl]amino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C45H66N2O5	3
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
2	EC50 = 21 nM Bioactivity Info	TI LI LO TS
3	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0405456 Compound Info	(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-9-(4-carboxyphenyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysene-3a-carboxylic acid Show/Hide	C37H50O4	3
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
2	EC50 = 150 nM Bioactivity Info	TI LI LO TS
3	IC50 = 233 nM Bioactivity Info	TI LI LO TS
CP0394381 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[[3-(dimethylamino)propylamino]methyl]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C42H64N2O2	3
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
2	EC50 = 160 nM Bioactivity Info	TI LI LO TS
3	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0470657 Compound Info	4-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-[(2-piperidin-1-ylethylamino)methyl]-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]benzoic acid Show/Hide	C44H66N2O2	3
1	EC50 = 51 nM Bioactivity Info	TI LI LO TS
2	EC50 = 210 nM Bioactivity Info	TI LI LO TS
3	IC50 = 390 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

100% Identity

Protein ID	Protein Name	Protein Organism
PT00004	Pol polyprotein	Human immunodeficiency virus 1	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han