General Information of the Protein
Protein ID
PT03540
Protein Name
G protein-coupled receptor 88
Secondarily
Protein Name
Striatum-specific G-protein coupled receptor
Gene Name
GPR88
Secondarily
Gene Name
STRG
Sequence
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
Function
Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473).
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Uniprot ID
Primary ID:
Q9GZN0

Secondarily ID:
Q29S24
Q6VN48
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HGNC ID
HGNC:4539
Subcellular Location
Cell membrane
Cell projection
Cilium membrane
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0385472
 Compound Info 
(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-ylcyclopropane-1-carboxamide
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C30H37N3O
  1
1
EC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579787
 Compound Info 
(2S)-N-[(1S)-2-(5-amino-1,3,4-oxadiazol-2-yl)-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
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C25H32N4O3
  1
1
EC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0572976
 Compound Info 
(2S)-N-[(1R)-2-(methylamino)-1-[4-(2-methylpentoxy)phenyl]-2-oxoethyl]-2-phenylpropanamide
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C24H32N2O3
  1
1
EC50 = 295 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385442
 Compound Info 
(2S)-N-[(1R)-2-amino-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
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C23H32N2O2
  1
1
EC50 = 414 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0558121
 Compound Info 
(2S)-N-[(R)-(5-methyl-1,3,4-oxadiazol-2-yl)-[4-(2-methylpentoxy)phenyl]methyl]-2-phenylpropanamide
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C25H31N3O3
  1
1
EC50 = 525 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0507405
 Compound Info 
(2S)-N-[(1R)-1-[4-(cyclobutylmethoxy)phenyl]-2-oxo-2-(1,3-thiazol-2-ylmethylamino)ethyl]-2-phenylpropanamide
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C26H29N3O3S
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0465025
 Compound Info 
(2R)-2-[4-(2-methylpentoxy)phenyl]-2-[[(2S)-2-phenylpropanoyl]amino]acetic acid
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C23H29NO4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0465028
 Compound Info 
methyl (2R)-2-[[2-(4-cyanophenyl)acetyl]amino]-2-[4-(2-methylpentoxy)phenyl]acetate
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C24H28N2O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0565313
 Compound Info 
methyl (2R)-2-(2-cyclohexylpropanoylamino)-2-[4-(2-methylpentoxy)phenyl]acetate
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C24H37NO4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466089
 Compound Info 
(2S)-N-[(1R)-2-hydroxy-1-[4-[(1-methylcyclobutyl)methoxy]phenyl]ethyl]-2-phenylpropanamide
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C23H29NO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466158
 Compound Info 
(2S)-N-[(1R)-2-hydroxy-1-[4-(spiro[2.3]hexan-5-ylmethoxy)phenyl]ethyl]-2-phenylpropanamide
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C24H29NO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558135
 Compound Info 
(2S)-N-[(1R)-1-[4-[(3,3-dimethylcyclobutyl)methoxy]phenyl]-2-hydroxyethyl]-2-phenylpropanamide
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C24H31NO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558136
 Compound Info 
(2S)-N-[(1R)-2-(azetidin-3-ylmethylamino)-1-[4-(2-methylpentoxy)phenyl]-2-oxoethyl]-2-phenylpropanamide
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C27H37N3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0398743
 Compound Info 
(2S)-N-[(1R)-2-(dimethylamino)-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
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C25H36N2O2
  1
1 EC50 = 39 nM
CP0494566
 Compound Info 
(2S)-N-[(1R)-2-amino-1-[4-[(2S)-2-methylbutoxy]phenyl]ethyl]-2-phenylpropanamide
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C22H30N2O2
  1
1 EC50 = 39 nM
CP0498100
 Compound Info 
(2S)-N-[(1R)-2-hydroxy-2-methyl-1-[4-(2-methylpentoxy)phenyl]propyl]-2-phenylpropanamide
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C25H35NO3
  1
1 EC50 = 39 nM
CP0385442
 Compound Info 
(2S)-N-[(1R)-2-amino-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
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C23H32N2O2
  1
1 EC50 = 54 nM
CP0212296
 Compound Info 
(2S)-N-[(1R)-2-hydroxy-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
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C23H31NO3
  1
1 EC50 = 100 nM
CP0223632
 Compound Info 
(2S)-N-[(1R)-1-[4-(2-methylpentoxy)phenyl]-2-morpholin-4-ylethyl]-2-phenylpropanamide
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C27H38N2O3
  1
1 EC50 = 100 nM
Clinical Information about the Protein
Target 1 ( Striatum-specific G-protein coupled receptor (GPR88) )
Target Type Literature-reported Target