General Information of the Protein
Protein ID
PT03206
Protein Name
Beta-secretase 1
Secondarily
Protein Name
Aspartyl protease 2
Beta-site amyloid precursor protein cleaving enzyme 1
Memapsin-2
Membrane-associated aspartic protease 2
Gene Name
BACE1
Secondarily
Gene Name
Bace
Sequence
MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091).
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Uniprot ID
Primary ID:
P56818

Secondarily ID:
Q544D0
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Ensembl ID
ENSG00000186318
Subcellular Location
Cell membrane
Golgi apparatus
Trans-Golgi network
Endoplasmic reticulum
Endosome
Late endosome
Early endosome
Cell surface
Cytoplasmic vesicle membrane
Membrane raft
Lysosome
Recycling endosome
Cell projection
Axon
Cell projection
Dendrite
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000020 , Neuro-2a
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0188117
 Compound Info 
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
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C17H18FN5O3
  1
1
IC50 = 4.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0202840
 Compound Info 
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
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C17H16ClFN4O2
  1
1
IC50 = 4.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204164
 Compound Info 
N-[3-[(3R)-5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]phenyl]-5-chloropyridine-2-carboxamide
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C17H17ClN4O2
  1
1
IC50 = 7.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01020 Beta-secretase 1 Homo sapiens, Human
 Protein Info