General Information of the Protein
Protein ID
PT03015
Protein Name
Kallikrein-7
Secondarily
Protein Name
Serine protease 6
Stratum corneum chymotryptic enzyme
Gene Name
KLK7
Secondarily
Gene Name
PRSS6
SCCE
Sequence
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
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Uniprot ID
Primary ID:
P49862

Secondarily ID:
A8K0U5
Q8N5N9
Q8NFV7
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Ensembl ID
ENSG00000169035
HGNC ID
HGNC:6368
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0579113
 Compound Info 
5-[2-[2-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[2-[2-[2-[[(5S)-6-[(2-amino-2-oxoethyl)amino]-5-[[2-[[(3R,6S,9S,12S,15S,18S,21R)-12-butyl-6-(3-carbamimidamidopropyl)-15-[(4-hydroxyphenyl)methyl]-9-methyl-18-(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]acetyl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-(hexadecanoylamino)-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylcarbamoyl]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
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C147H208N26O43S2
  1
1
Ki = 7 nM
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CP0579037
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-20-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C46H70N12O12S2
  1
1
Ki = 8.8 nM
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CP0578391
 Compound Info 
(2S)-5-amino-2-[[(3R,11R,14S,17S,20S,23S)-17,20-bis(3-amino-3-oxopropyl)-3-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(3R,6S,9S,12S,15S,18S,21R)-6-(3-carbamimidamidopropyl)-21-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-15-[(4-hydroxyphenyl)methyl]-9-methyl-18-(2-methylpropyl)-12-(2-methylsulfanylethyl)-5,8,11,14,17,20,25-heptaoxo-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-14-[(4-hydroxyphenyl)methyl]-2,7,13,16,19,22-hexaoxo-5,9-dithia-1,12,15,18,21-pentazabicyclo[21.3.0]hexacosane-11-carbonyl]amino]-5-oxopentanoic acid
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C94H141N25O28S5
  1
1
Ki = 9 nM
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CP0578266
 Compound Info 
(2S)-2-[[(3R,6S,9S,12S,15S,18S,21R)-6-[3-(diaminomethylideneamino)propyl]-15-[(4-hydroxyphenyl)methyl]-9-methyl-18-(2-methylpropyl)-12-(2-methylsulfanylethyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]-3-hydroxypropanoic acid
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C46H72N12O13S3
  1
1
Ki = 10.1 nM
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CP0550173
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-20-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C45H66N10O13S2
  1
1
Ki = 12 nM
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CP0550175
 Compound Info 
(2S)-2-[[(3R,6S,9S,12S,15S,18S,21S)-6-[3-(diaminomethylideneamino)propyl]-15-[(4-hydroxyphenyl)methyl]-9-methyl-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]-3-hydroxypropanoic acid
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C47H74N12O13S2
  1
1
Ki = 16 nM
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CP0575919
 Compound Info 
(2S)-3-hydroxy-2-[[(5R,8S,11S,14S,17S,20R)-14-[(4-hydroxyphenyl)methyl]-8-methyl-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]propanoic acid
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C45H65N9O11S2
  1
1
Ki = 17.5 nM
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CP0578484
 Compound Info 
(5R,8S,11S,14S,17S,20R)-14-[(4-hydroxyphenyl)methyl]-8-methyl-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carboxylic acid
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C42H60N8O9S2
  1
1
Ki = 19 nM
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CP0579112
 Compound Info 
(3R,6S,9S,12S,15S,18S,21R)-6-[3-(diaminomethylideneamino)propyl]-15-[(4-hydroxyphenyl)methyl]-9-methyl-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carboxylic acid
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C44H69N11O11S2
  1
1
Ki = 29 nM
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CP0578392
 Compound Info 
(2S)-3-hydroxy-2-[[(5R,8S,11S,14S,17S,20R)-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]propanoic acid
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C45H65N9O12S2
  1
1
Ki = 29.4 nM
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CP0578661
 Compound Info 
5-[2-[2-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[2-[2-[2-[[(5S)-6-[(2-amino-2-oxoethyl)amino]-5-[[2-[[(3R,6S,9S,12S,15S,18S,21R)-6-(3-carbamimidamidopropyl)-15-[(4-hydroxyphenyl)methyl]-9-methyl-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]acetyl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-(hexadecanoylamino)-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylcarbamoyl]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
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C147H208N26O43S2
  1
1
Ki = 31 nM
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CP0567951
 Compound Info 
2-[(5R,11S,14S,17R)-17-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(5R,8S,11S,14S,17S,20R)-11-[(2S)-butan-2-yl]-20-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-14-[(4-hydroxyphenyl)methyl]-8-methyl-17-(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]propanoyl]amino]hexanoyl]amino]-11-(2-amino-2-oxoethyl)-5-[[(2S)-1,5-diamino-1,5-dioxopentan-2-yl]carbamoyl]-7,10,13,16-tetraoxo-3,19-dithia-6,9,12,15,25-pentazabicyclo[19.3.1]pentacosa-1(24),21(25),22-trien-14-yl]acetic acid
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C90H133N25O25S4
  1
1
Ki = 32 nM
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CP0577213
 Compound Info 
(2S)-2-[[(3R,6S,9S,12S,15S,18S,21R)-6-(3-amino-3-oxopropyl)-15-[(4-hydroxyphenyl)methyl]-9-methyl-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]-3-hydroxypropanoic acid
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C46H70N10O14S2
  1
1
Ki = 36 nM
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CP0578393
 Compound Info 
(2S)-N-[(5R,8S,11S,14S,17S,20R)-5-[(2S)-2-acetylpyrrolidine-1-carbonyl]-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-trien-20-yl]pyrrolidine-2-carboxamide
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C48H69N9O10S2
  1
1
Ki = 50 nM
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CP0550174
 Compound Info 
(2S)-3-hydroxy-2-[[(5R,8S,11S,14S,17S,20R)-8-[(1R)-1-hydroxyethyl]-14-[(4-hydroxyphenyl)methyl]-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]propanoic acid
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C46H67N9O12S2
  1
1
Ki = 52 nM
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CP0569578
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-11-[3-(diaminomethylideneamino)propyl]-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-17-(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C45H66N12O12S2
  1
1
Ki = 53 nM
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CP0964728
 Compound Info 
2-[(5R,8S,11S,17S,20S,23S,26R)-26-[(2S)-2-[[(1S)-4-amino-1-[[(5R,8S,11S,14S,17S,20R)-20-[[(1S)-2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-14-(3-guanidinopropyl)-11-[(4-hydroxyphenyl)methyl]-8-isobutyl-17-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-3,22-dithia-7,10,13,16,19,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-trien-5-yl]carbamoyl]-4-oxo-butyl]carbamoyl]pyrrolidine-1-carbonyl]-11-(4-aminobutyl)-5-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-8,23-bis(3-guanidinopropyl)-17-isobutyl-6,9,12,15,18,21,24-heptaoxo-3,28-dithia-7,10,13,16,19,22,25,34-octazabicyclo[28.3.1]tetratriaconta-1(33),30(34),31-trien-20-yl]acetic acid
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C102H158N34O23S4
  1
1
Ki = 66 nM
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CP0580052
 Compound Info 
(2S)-2-[[(3S,6S,9S,12S,15S,18S,21S)-6-[3-(diaminomethylideneamino)propyl]-9-(hydroxymethyl)-15-[(4-hydroxyphenyl)methyl]-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-21-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacosane-3-carbonyl]amino]-3-hydroxypropanoic acid
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C47H74N12O14S2
  1
1
Ki = 90 nM
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CP0547025
 Compound Info 
(2S)-1-[(5R,8S,11S,14S,17S,20R)-20-[[(2S)-5-amino-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(5R,8S,11S,14S,17S,20R)-20-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-8-(3-amino-3-oxopropyl)-17-(carboxymethyl)-11,14-bis(hydroxymethyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-11-(3-carbamimidamidopropyl)-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-17-(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]pyrrolidine-2-carboxylic acid
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C93H139N29O28S5
  1
1
Ki = 94 nM
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CP0954575
 Compound Info 
(3S)-3-[[(2S)-2-[[(2S,3S)-2-[[(3R,6S,9S,12S,16S,19S,22S,25R)-9-(3-amino-3-oxo-propyl)-6-benzyl-25-[[(2S)-2,5-diamino-5-oxo-pentanoyl]amino]-16-[(1R)-1-hydroxyethyl]-12-[(4-hydroxyphenyl)methyl]-19,22-bis[(1S)-1-methylpropyl]-5,8,11,14,18,21,24,29-octaoxo-1,27-dithia-4,7,10,13,15,17,20,23-octazacyclotriacontane-3-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-[[(1S)-1-[[(1S)-2-[[2-[[(3R,6R)-3-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]-5,10-dioxo-1,8-dithia-4-azacycloundec-6-yl]amino]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-4-oxo-butanoic acid
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C96H138N26O30S4
  1
1
Ki = 96 nM
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CP0550172
 Compound Info 
5-[2-[2-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[2-[2-[2-[(2S)-2-[[(3R,6S,9S,12S,15S,18S,21R)-3-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]-6-(3-carbamimidamidopropyl)-15-[(4-hydroxyphenyl)methyl]-9-methyl-12,18-bis(2-methylpropyl)-5,8,11,14,17,20,25-heptaoxo-1,23-dithia-4,7,10,13,16,19-hexazacyclohexacos-21-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethoxy]ethoxy]ethylamino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-(hexadecanoylamino)-1-oxohexan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylcarbamoyl]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
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C140H195N23O42S2
  1
1
Ki = 106 nM
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CP0577543
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-20-amino-14-[(4-hydroxyphenyl)methyl]-8-methyl-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C40H58N8O10S2
  1
1
Ki = 200 nM
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CP0579111
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-14-benzyl-8-(hydroxymethyl)-11,17-bis(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C45H65N9O11S2
  1
1
Ki = 220 nM
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CP0569983
 Compound Info 
(2S)-2-[[(5R,8S,11S,14S,17S,20R)-11-(3-amino-3-oxopropyl)-8-(hydroxymethyl)-14-[(4-hydroxyphenyl)methyl]-17-(2-methylpropyl)-7,10,13,16,19-pentaoxo-20-[[(2S)-pyrrolidine-2-carbonyl]amino]-3,22-dithia-6,9,12,15,18,28-hexazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]amino]-3-hydroxypropanoic acid
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C44H62N10O13S2
  1
1
Ki = 440 nM
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CP0969452
 Compound Info 
(2S)-2-[[(3R,11R,14S,17S,20S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-5-amino-2-[[(3S,6S,9R,17R,20S,23S)-9-[[(2S)-2-amino-3-phenyl-propanoyl]amino]-3,20-bis(1H-indol-3-ylmethyl)-6-isobutyl-2,5,8,13,19,22-hexaoxo-11,15-dithia-1,4,7,18,21-pentazabicyclo[21.3.0]hexacosane-17-carbonyl]amino]-5-oxo-pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-4-carboxy-butanoyl]amino]propanoyl]amino]-14-(3-amino-3-oxo-propyl)-17-(hydroxymethyl)-2,7,13,16,19-pentaoxo-5,9-dithia-1,12,15,18-tetrazabicyclo[18.3.0]tricosane-11-carbonyl]amino]pentanedioic acid
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C101H134N22O28S4
  1
1
Ki > 1000 nM
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Cell Line ID: CL000265 , NS0
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Kallikrein-7 (KLK7) )
Target Type Patented-recorded Target