General Information of the Protein
Protein ID
PT03001
Protein Name
S-adenosylmethionine synthase isoform type-2
Secondarily
Protein Name
Methionine adenosyltransferase 2
Methionine adenosyltransferase II
Gene Name
MAT2A
Secondarily
Gene Name
AMS2
MATA2
Sequence
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
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Uniprot ID
Primary ID:
P31153

Secondarily ID:
A8K511
B4DN45
D6W5L1
Q53SP5
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Ensembl ID
ENSG00000168906
HGNC ID
HGNC:6904
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000067 , HCT 116
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0568295
 Compound Info 
8-(4-chlorophenyl)-2-(ethylamino)-6-(2-methylindazol-5-yl)-1,6-naphthyridin-7-one
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C24H20ClN5O
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574625
 Compound Info 
8-(4-chlorophenyl)-6-(2-methylindazol-5-yl)-2-(2,2,2-trifluoroethylamino)-1,6-naphthyridin-7-one
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C24H17ClF3N5O
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547283
 Compound Info 
8-(4-chlorophenyl)-2-(2,2-difluoroethoxy)-6-(2-methylindazol-5-yl)-1,6-naphthyridin-7-one
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C24H17ClF2N4O2
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568186
 Compound Info 
8-(4-chlorophenyl)-6-(2-methylindazol-5-yl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C23H16ClF3N6O
  1
1
IC50 = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569201
 Compound Info 
8-(4-chlorophenyl)-6-(2,3-dimethylbenzimidazol-5-yl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C24H18ClF3N6O
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568348
 Compound Info 
8-(4-chlorophenyl)-2-ethoxy-6-(2-methylindazol-5-yl)-1,6-naphthyridin-7-one
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C24H19ClN4O2
  1
1
IC50 = 23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574249
 Compound Info 
8-(4-chlorophenyl)-6-(3-methylbenzimidazol-5-yl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C23H16ClF3N6O
  1
1
IC50 = 31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547282
 Compound Info 
8-(4-chlorophenyl)-6-(2-methylindazol-5-yl)-2-(2,2,2-trifluoroethoxy)-1,6-naphthyridin-7-one
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C24H16ClF3N4O2
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568859
 Compound Info 
8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C22H16BrF3N4O2
  1
1
IC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568185
 Compound Info 
8-(4-bromophenyl)-6-quinolin-6-yl-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C24H15BrF3N5O
  1
1
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547280
 Compound Info 
8-(4-chlorophenyl)-6-quinolin-6-yl-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C24H15ClF3N5O
  1
1
IC50 = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466410
 Compound Info 
4-[4-(difluoromethoxy)phenyl]-2-(2-methylindazol-5-yl)-6-(2,2,2-trifluoroethoxy)pyrido[3,2-c]pyridazin-3-one
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C24H16F5N5O3
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0466411
 Compound Info 
6-(2,2-difluoroethoxy)-4-[4-(difluoromethoxy)phenyl]-2-(2,3-dihydro-1-benzofuran-5-yl)pyrido[3,2-c]pyridazin-3-one
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C24H17F4N3O4
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0487495
 Compound Info 
2-(1,3-benzothiazol-6-yl)-6-(2,2-difluoroethoxy)-4-[4-(difluoromethoxy)phenyl]pyrido[3,2-c]pyridazin-3-one
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C23H14F4N4O3S
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0507631
 Compound Info 
6-(2,2-difluoroethoxy)-4-(6-methoxypyridin-3-yl)-2-(2-methylindazol-5-yl)pyrido[3,2-c]pyridazin-3-one
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C23H18F2N6O3
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553141
 Compound Info 
4-(4-chlorophenyl)-2-(2-methylindazol-5-yl)-6-(2,2,2-trifluoroethoxy)pyrido[3,2-c]pyridazin-3-one
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C23H15ClF3N5O2
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0556540
 Compound Info 
4-[4-(difluoromethoxy)phenyl]-2-(2-methylindazol-5-yl)-6-(2,2,2-trifluoroethylsulfanyl)pyrido[3,2-c]pyridazin-3-one
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C24H16F5N5O2S
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568372
 Compound Info 
6-(2,2-difluoroethoxy)-4-[4-(difluoromethoxy)phenyl]-2-(2-methylindazol-5-yl)pyrido[3,2-c]pyridazin-3-one
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C24H17F4N5O3
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569312
 Compound Info 
6-ethoxy-4-(4-methoxyphenyl)-2-(2-methylindazol-5-yl)pyrido[3,2-c]pyridazin-3-one
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C24H21N5O3
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569313
 Compound Info 
6-(2,2-difluoroethoxy)-4-[4-(difluoromethoxy)phenyl]-2-[2-methyl-3-(trideuteriomethoxy)indazol-5-yl]pyrido[3,2-c]pyridazin-3-one
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C25H19F4N5O4
  1
1
IC50 < 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547279
 Compound Info 
8-(4-chlorophenyl)-6-(2-methylindazol-5-yl)-2-(3,3,3-trifluoropropyl)-1,6-naphthyridin-7-one
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C25H18ClF3N4O
  1
1
IC50 = 101 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568184
 Compound Info 
8-(4-chlorophenyl)-6-(4-methoxyphenyl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one
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C22H16ClF3N4O2
  1
1
IC50 = 113 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0556615
 Compound Info 
4-[4-(difluoromethoxy)phenyl]-2-(2-methylindazol-5-yl)-6-(3,3,3-trifluoropropoxy)pyrido[3,2-c]pyridazin-3-one
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C25H18F5N5O3
  1
1
IC50 >= 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0423491
 Compound Info 
CHEMBL4859703
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C19H15N3O
  2
1 IC50 = 1500 nM
2 Kd = 70000 nM
Clinical Information about the Protein
Target 1 ( S-adenosylmethionine synthase type-2 (MAT2A) )
Target Type Clinical trial Target