Protein Information

General Information of the Protein

Protein ID	PT02963
Protein Name	Neuromedin-B receptor
Secondarily Protein Name	Epididymis tissue protein Li 185a Neuromedin-B-preferring bombesin receptor
Gene Name	NMBR
Sequence	MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Neuromedin receptor
Function	Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). Show/Hide
Uniprot ID	Primary ID: P28336 Secondarily ID: E9KL38 Q5VUK8 Show/Hide
HGNC ID	HGNC:7843
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0233482 Compound Info	(2S)-2-[(2-aminoacetyl)amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide Show/Hide	C52H73N15O12S	2
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.068 nM Bioactivity Info	TI LI LO TS
CP0377472 Compound Info	(2S)-2-[[(2S)-2-[[(2S)-2-[3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoylamino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid Show/Hide	C58H79N11O11	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0384214 Compound Info	(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]butanediamide Show/Hide	C130H204N38O31S2	1
1	EC50 = 3200 nM Bioactivity Info	TI LI LO TS
CP0885912 Compound Info	2-Phenylacetylamino-pentanedioic acid 5-amide 1-{[2-(1H-indol-3-yl)-1-phenethylcarbamoyl-ethyl]-amide} Show/Hide	C32H35N5O4	1
1	EC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0885728 Compound Info	2-[2-(4-Chloro-phenyl)-acetylamino]-pentanedioic acid 5-amide 1-{[2-(1H-indol-3-yl)-1-phenethylcarbamoyl-ethyl]-amide} Show/Hide	C32H34ClN5O4	1
1	EC50 = 18500 nM Bioactivity Info	TI LI LO TS
CP0286826 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H34N6O4	1
1	Ki = 0.15 nM Bioactivity Info	TI LI LO TS
CP0377937 Compound Info	(S)-3-(1H-Indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C32H36N6O5	1
1	Ki = 0.17 nM Bioactivity Info	TI LI LO TS
CP0208329 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-N-[1-(4-nitro-phenyl)-cyclohexylmethyl]-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C32H34N6O6	1
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0276615 Compound Info	(S)-2-[3-(4-Cyano-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C32H34N6O2	1
1	Ki = 0.32 nM Bioactivity Info	TI LI LO TS
CP0285115 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-N-(1-phenyl-cyclohexylmethyl)-propionamide Show/Hide	C32H35N5O4	1
1	Ki = 0.39 nM Bioactivity Info	TI LI LO TS
CP0083975 Compound Info	(S)-N-[1-(3,4-Dimethoxy-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C34H39N5O6	1
1	Ki = 0.44 nM Bioactivity Info	TI LI LO TS
CP0537989 Compound Info	(S)-3-(1H-Indol-3-yl)-N-[1-(4-methoxy-phenyl)-cyclohexylmethyl]-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C33H37N5O5	1
1	Ki = 0.46 nM Bioactivity Info	TI LI LO TS
CP0286266 Compound Info	(S)-N-[1-(4-Dimethylamino-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C34H40N6O4	1
1	Ki = 0.52 nM Bioactivity Info	TI LI LO TS
CP0101710 Compound Info	(S)-N-[1-(4-Ethoxy-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C34H39N5O5	1
1	Ki = 0.59 nM Bioactivity Info	TI LI LO TS
CP0048706 Compound Info	(S)-N-[1-(4-Hydroxy-phenyl)-cyclohexylmethyl]-3-(1H-indol-3-yl)-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C32H35N5O5	1
1	Ki = 0.62 nM Bioactivity Info	TI LI LO TS
CP0184548 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(3-nitro-phenyl)-ureido]-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H34N6O4	1
1	Ki = 0.97 nM Bioactivity Info	TI LI LO TS
CP0203828 Compound Info	(S)-3-(1H-Indol-3-yl)-N-[1-(4-isopropyl-phenyl)-cyclohexylmethyl]-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C35H41N5O4	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0228324 Compound Info	Bombesin Show/Hide	C71H110N24O18S	1
1	Ki = 2 nM Bioactivity Info	TI LI LO TS
CP0112853 Compound Info	AcBB(7-14) Show/Hide	C45H67N13O10S	1
1	Ki = 2.1 nM Bioactivity Info	TI LI LO TS
CP0301458 Compound Info	(S)-2-[3-(3,4-Dichloro-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H33Cl2N5O2	1
1	Ki = 2.1 nM Bioactivity Info	TI LI LO TS
CP0430110 Compound Info	Bombesin analogue Show/Hide	C51H72N10O12	1
1	Ki = 2.1 nM Bioactivity Info	TI LI LO TS
CP0276024 Compound Info	(S)-2-[3-(4-Chloro-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H34ClN5O2	1
1	Ki = 2.8 nM Bioactivity Info	TI LI LO TS
CP0088507 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-2-[3-(4-trifluoromethyl-phenyl)-ureido]-propionamide Show/Hide	C32H34F3N5O2	1
1	Ki = 2.9 nM Bioactivity Info	TI LI LO TS
CP0359450 Compound Info	(S)-3-(1H-Indol-3-yl)-N-[1-(2-methoxy-phenyl)-cyclohexylmethyl]-2-methyl-2-[3-(4-nitro-phenyl)-ureido]-propionamide Show/Hide	C33H37N5O5	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0052175 Compound Info	(S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C37H47N5O2	1
1	Ki = 6.3 nM Bioactivity Info	TI LI LO TS
CP0439263 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-phenyl-cyclohexylmethyl)-propionamide Show/Hide	C38H48N4O2	1
1	Ki = 7.8 nM Bioactivity Info	TI LI LO TS
CP0223122 Compound Info	(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid Show/Hide	C130H203N37O32S2	1
1	Ki = 9.1 nM Bioactivity Info	TI LI LO TS
CP0498046 Compound Info	(S)-3-(1H-Indol-3-yl)-2-[3-(4-isopropyl-phenyl)-ureido]-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C34H41N5O2	1
1	Ki = 9.4 nM Bioactivity Info	TI LI LO TS
CP0375929 Compound Info	(2R)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-2-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide Show/Hide	C35H42N4O2	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0284508 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-2-(3-phenyl-ureido)-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H35N5O2	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0493868 Compound Info	(1-tritylimidazol-4-yl)methyl N-[3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C39H39N5O3	1
1	Ki = 37 nM Bioactivity Info	TI LI LO TS
CP0439332 Compound Info	(R) 2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionamide Show/Hide	C35H42N4O2	1
1	Ki = 72 nM Bioactivity Info	TI LI LO TS
CP0405291 Compound Info	(2S)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-2-methyl-N-(2-phenylcyclohexyl)propanamide Show/Hide	C37H46N4O2	1
1	Ki = 76 nM Bioactivity Info	TI LI LO TS
CP0505439 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-N-((S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-3-(1H-indol-3-yl)-2-methyl-propionamide Show/Hide	C37H46N4O4	1
1	Ki = 95 nM Bioactivity Info	TI LI LO TS
CP0503475 Compound Info	N-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)propanamide Show/Hide	C31H42N4O2	1
1	Ki = 120 nM Bioactivity Info	TI LI LO TS
CP0405224 Compound Info	N-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-2-methylpropanamide Show/Hide	C32H44N4O2	1
1	Ki = 125 nM Bioactivity Info	TI LI LO TS
CP0184168 Compound Info	(S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(2-nitro-phenyl)-ureido]-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C31H34N6O4	1
1	Ki = 184 nM Bioactivity Info	TI LI LO TS
CP0430109 Compound Info	N-(cyclohexylmethyl)-2-[[[2,6-di(propan-2-yl)phenyl]-methylcarbamoyl]amino]-3-(1H-indol-3-yl)propanamide Show/Hide	C32H44N4O2	1
1	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0494327 Compound Info	N-cyclohexyl-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-2-methylpropanamide Show/Hide	C31H42N4O2	1
1	Ki = 310 nM Bioactivity Info	TI LI LO TS
CP0532766 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1,2,3,4-tetrahydro-naphthalen-2-yl)-propionamide Show/Hide	C35H42N4O2	1
1	Ki = 310 nM Bioactivity Info	TI LI LO TS
CP0429854 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-N-((R)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-3-(1H-indol-3-yl)-2-methyl-propionamide Show/Hide	C37H46N4O4	1
1	Ki = 420 nM Bioactivity Info	TI LI LO TS
CP0510667 Compound Info	N-(1-cyclohexylethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)propanamide Show/Hide	C32H44N4O2	1
1	Ki = 440 nM Bioactivity Info	TI LI LO TS
CP0471803 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-phenethyl-propionamide Show/Hide	C33H40N4O2	1
1	Ki = 450 nM Bioactivity Info	TI LI LO TS
CP0403347 Compound Info	N-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoylamino]-3-(1H-indol-3-yl)-N-methylpropanamide Show/Hide	C32H44N4O2	1
1	Ki = 490 nM Bioactivity Info	TI LI LO TS
CP0536856 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-N-(2,2-dimethyl-[1,3]dioxan-5-yl)-3-(1H-indol-3-yl)-2-methyl-propionamide Show/Hide	C31H42N4O4	1
1	Ki = 630 nM Bioactivity Info	TI LI LO TS
CP0488194 Compound Info	N-(cyclohexylmethyl)-2-[[2,6-di(propan-2-yl)phenyl]carbamoyl-methylamino]-3-(1H-indol-3-yl)propanamide Show/Hide	C32H44N4O2	1
1	Ki = 760 nM Bioactivity Info	TI LI LO TS
CP0437230 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C32H31N5O3	1
1	Ki = 980 nM Bioactivity Info	TI LI LO TS
CP0542516 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C30H30N4O3	1
1	Ki = 1100 nM Bioactivity Info	TI LI LO TS
CP0293937 Compound Info	benzyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C27H27N3O3	1
1	Ki = 2600 nM Bioactivity Info	TI LI LO TS
CP0498055 Compound Info	1H-imidazol-5-ylmethyl N-[3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C24H25N5O3	1
1	Ki = 2600 nM Bioactivity Info	TI LI LO TS
CP0493896 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C27H32N4O3	1
1	Ki = 2700 nM Bioactivity Info	TI LI LO TS
CP0537750 Compound Info	1H-imidazol-5-ylmethyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C24H25N5O3	1
1	Ki = 2700 nM Bioactivity Info	TI LI LO TS
CP0403944 Compound Info	benzyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C29H28N4O3	1
1	Ki = 2800 nM Bioactivity Info	TI LI LO TS
CP0505347 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C26H30N4O3	1
1	Ki = 3500 nM Bioactivity Info	TI LI LO TS
CP0405155 Compound Info	1H-imidazol-5-ylmethyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C26H26N6O3	1
1	Ki = 3700 nM Bioactivity Info	TI LI LO TS
CP0430108 Compound Info	2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2,N-dimethyl-propionamide Show/Hide	C26H34N4O2	1
1	Ki = 3700 nM Bioactivity Info	TI LI LO TS
CP0535508 Compound Info	1H-imidazol-5-ylmethyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C21H27N5O3	1
1	Ki = 3900 nM Bioactivity Info	TI LI LO TS
CP0946549 Compound Info	[2-(1H-Indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-carbamic acid 1H-imidazol-4-ylmethyl ester Show/Hide	C21H27N5O3	1
1	Ki = 3900 nM Bioactivity Info	TI LI LO TS
CP0456580 Compound Info	2-methylpropyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C24H29N3O3	1
1	Ki = 4300 nM Bioactivity Info	TI LI LO TS
CP0380724 Compound Info	2-methylpropyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C26H30N4O3	1
1	Ki = 4700 nM Bioactivity Info	TI LI LO TS
CP0498095 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C27H28N6O3	1
1	Ki = 5000 nM Bioactivity Info	TI LI LO TS
CP0418803 Compound Info	benzyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C24H29N3O3	1
1	Ki = 6100 nM Bioactivity Info	TI LI LO TS
CP0465069 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C27H33N5O3	1
1	Ki = 7800 nM Bioactivity Info	TI LI LO TS
CP0535510 Compound Info	4-aminobutyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C26H31N5O3	1
1	Ki = 8900 nM Bioactivity Info	TI LI LO TS
CP0380438 Compound Info	2-[[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyloxy]acetic acid Show/Hide	C16H19N3O6	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0380723 Compound Info	propan-2-yl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C17H23N3O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0393446 Compound Info	4-aminobutyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C21H32N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0395080 Compound Info	3-[(S)-3-(1H-Indol-3-yl)-2-isopropoxycarbonylamino-propionylamino]-propionic acid Show/Hide	C18H23N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0402207 Compound Info	2-[[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamoyloxy]acetic acid Show/Hide	C18H23N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0408408 Compound Info	benzyl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C24H30N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0408506 Compound Info	4-aminobutyl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C21H28N6O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0410893 Compound Info	2-[[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamoyloxy]acetic acid Show/Hide	C19H25N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0419188 Compound Info	methyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C21H23N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0424420 Compound Info	propan-2-yl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C25H28N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430293 Compound Info	3-[(S)-3-(1H-Indol-3-yl)-2-isobutoxycarbonylamino-propionylamino]-propionic acid Show/Hide	C19H25N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430294 Compound Info	4-aminobutyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C20H30N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430483 Compound Info	2-methylpropyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C21H31N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430744 Compound Info	benzyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C23H27N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430818 Compound Info	propan-2-yl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C19H27N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0437229 Compound Info	propan-2-yl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C20H30N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0437231 Compound Info	2-methylpropyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C20H29N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0453433 Compound Info	propan-2-yl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C23H27N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0457251 Compound Info	methyl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C18H25N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0461037 Compound Info	3-[(S)-3-(1H-Indol-3-yl)-2-methoxycarbonylamino-propionylmino]-propionic acid Show/Hide	C16H19N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0465022 Compound Info	benzyl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C21H23N3O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0465052 Compound Info	propan-2-yl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C20H25N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0466566 Compound Info	methyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C17H23N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0467137 Compound Info	2-[[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamoyloxy]acetic acid Show/Hide	C24H24N4O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0467617 Compound Info	methyl N-[(2S)-3-(1H-indol-3-yl)-1-[2-(1H-indol-3-yl)ethylamino]-1-oxopropan-2-yl]carbamate Show/Hide	C23H24N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0488221 Compound Info	3-[(S)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-propionic acid Show/Hide	C22H23N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0488222 Compound Info	2-[[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyloxy]acetic acid Show/Hide	C19H26N4O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0493869 Compound Info	4-aminobutyl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C18H26N4O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0494322 Compound Info	2-methylpropyl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C21H32N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0496840 Compound Info	4-aminobutyl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C21H33N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0498158 Compound Info	2-methylpropyl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C18H25N3O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0498167 Compound Info	methyl N-[(2S)-1-(5-aminopentylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C18H26N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0505106 Compound Info	propan-2-yl N-[(2S)-3-(1H-indol-3-yl)-1-(3-methylbutylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C20H29N3O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0506985 Compound Info	methyl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C18H21N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0507454 Compound Info	1H-imidazol-5-ylmethyl N-[(2S)-3-(1H-indol-3-yl)-1-(2-methylpropylamino)-1-oxopropan-2-yl]carbamate Show/Hide	C20H25N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0515882 Compound Info	methyl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C15H19N3O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0535168 Compound Info	benzyl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C24H25N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0535507 Compound Info	2-(1H-indol-3-yl)ethyl N-[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C24H26N4O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0536476 Compound Info	2-methylpropyl N-[(2S)-1-[2-(1H-imidazol-5-yl)ethylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate Show/Hide	C21H27N5O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0536657 Compound Info	2-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamoyloxy]acetic acid Show/Hide	C22H23N3O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0538343 Compound Info	4-aminobutyl N-[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]carbamate Show/Hide	C24H30N4O3	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0538461 Compound Info	3-[(S)-2-(4-Amino-butoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionic acid Show/Hide	C19H26N4O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0559511 Compound Info	3-{(S)-3-(1H-Indol-3-yl)-2-[2-(1H-indol-3-yl)-ethoxycarbonylamino]-propionylamino}-propionic acid Show/Hide	C25H26N4O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000943 , CellSensor NFAT-bla CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0052175 Compound Info	(S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide Show/Hide	C37H47N5O2	1
1	Ki = 6.3 nM
CP0341603 Compound Info	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]pentanediamide Show/Hide	C57H76N14O10	1
1	Ki = 8.9 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han