General Information of the Protein
| Protein ID |
PT02715
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| Protein Name |
Sonic hedgehog protein
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| Secondarily Protein Name |
HHG-1
Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
Shh N-terminal processed signaling domains
Sonic hedgehog protein 19 kDa product
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| Gene Name |
SHH
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| Secondarily Gene Name |
Hhg1
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| Sequence |
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Unclassified protein
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| Function |
The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723, PubMed:7736596). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192). Both activities occur in the reticulum endoplasmic (PubMed:21357747). Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747).
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| Subcellular Location |
Endoplasmic reticulum membrane
Golgi apparatus membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000387 , C3H/10T1/2 clone 8
Cell Line ID: CL000035 , NIH 3T3
Cell Line ID: CL000426 , Shh Light II
Biochemical Assays